PubRank

Klaus Kopka

Author PubWeight™ 34.97‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The diagnostic value of PET/CT imaging with the (68)Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging 2014 3.40
2 Scintigraphic imaging of matrix metalloproteinase activity in the arterial wall in vivo. Circulation 2004 1.57
3 Radiation dosimetry and first therapy results with a (124)I/ (131)I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy. Eur J Nucl Med Mol Imaging 2014 1.43
4 [¹⁷⁷Lu]Lutetium-labelled PSMA ligand-induced remission in a patient with metastatic prostate cancer. Eur J Nucl Med Mol Imaging 2015 1.08
5 Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases. Bioconjug Chem 2008 0.96
6 Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem 2007 0.93
7 Radiofluorinated pyrimidine-2,4,6-triones as molecular probes for noninvasive MMP-targeted imaging. ChemMedChem 2010 0.92
8 Encapsulating (111)In in nanocontainers for scintigraphic imaging: synthesis, characterization, and in vivo biodistribution. ACS Nano 2010 0.89
9 Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions. Eur J Nucl Med Mol Imaging 2007 0.87
10 PET/CT studies of multiple myeloma using (18) F-FDG and (18) F-NaF: comparison of distribution patterns and tracers' pharmacokinetics. Eur J Nucl Med Mol Imaging 2014 0.87
11 Whole-body PET/CT with 11C-meta-hydroxyephedrine in tumors of the sympathetic nervous system: feasibility study and comparison with 123I-MIBG SPECT/CT. J Nucl Med 2006 0.86
12 Preclinical evaluation of a bispecific low-molecular heterodimer targeting both PSMA and GRPR for improved PET imaging and therapy of prostate cancer. Prostate 2014 0.86
13 C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging. J Med Chem 2005 0.86
14 Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors. Bioorg Med Chem 2009 0.85
15 A closer look at the bromine-lithium exchange with tert-butyllithium in an aryl sulfonamide synthesis. Org Lett 2013 0.85
16 Molecular imaging of apoptosis in vivo with scintigraphic and optical biomarkers--a status report. Anticancer Agents Med Chem 2009 0.85
17 Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J Med Chem 2009 0.84
18 A new 18F-labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies. Appl Radiat Isot 2008 0.83
19 A new generation of radiofluorinated pyrimidine-2,4,6-triones as MMP-targeted radiotracers for positron emission tomography. J Med Chem 2011 0.82
20 Synthesis and first in vivo evaluation of new selective high affinity beta1-adrenoceptor radioligands for SPECT based on ICI 89,406. Bioorg Med Chem 2004 0.81
21 Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET? Eur J Nucl Med Mol Imaging 2007 0.81
22 Preclinical evaluation of an 18F-labelled beta1-adrenoceptor selective radioligand based on ICI 89,406. Nucl Med Biol 2010 0.81
23 Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents. Bioorg Med Chem 2013 0.81
24 Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography. J Med Chem 2013 0.81
25 A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem 2012 0.81
26 Metabolite identification of a radiotracer by electrochemistry coupled to liquid chromatography with mass spectrometric and radioactivity detection. Anal Chem 2011 0.80
27 Early assessment of the efficacy of temozolomide chemotherapy in experimental glioblastoma using [18F]FLT-PET imaging. PLoS One 2013 0.79
28 Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis. J Med Chem 2014 0.79
29 A fluorescent photoprobe for the imaging of endothelin receptors. Bioconjug Chem 2007 0.79
30 Radiosynthesis of a ⁶⁸Ga labeled matrix metalloproteinase inhibitor as a potential probe for PET imaging. Appl Radiat Isot 2012 0.78
31 Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels. Endocrinology 2008 0.78
32 Synthesis of geminal difluorides by oxidative desulfurization-difluorination of alkyl aryl thioethers with halonium electrophiles in the presence of fluorinating reagents and its application for 18F-radiolabeling. J Org Chem 2010 0.78
33 The MMP inhibitor (R)-2-(N-benzyl-4-(2-[18F]fluoroethoxy)phenylsulphonamido)-N-hydroxy-3-methylbutanamide: Improved precursor synthesis and fully automated radiosynthesis. Appl Radiat Isot 2011 0.78
34 Synthesis and evaluation of a novel hydroxamate based fluorescent photoprobe for imaging of matrix metalloproteinases. Bioconjug Chem 2009 0.78
35 Synthesis and in vivo evaluation of an (18)F-labeled glycoconjugate of PD156707 for imaging ETA receptor expression in thyroid carcinoma by positron emission tomography. Am J Nucl Med Mol Imaging 2013 0.77
36 Biodistribution of a nonpeptidic fluorescent endothelin A receptor imaging probe. Mol Imaging 2009 0.77
37 Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. J Med Chem 2011 0.77
38 PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem 2009 0.77
39 Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists. Org Biomol Chem 2015 0.76
40 68Ga-PSMA-11 Dynamic PET/CT Imaging in Primary Prostate Cancer. Clin Nucl Med 2016 0.76
41 Prognostic significance of amino acid transport imaging in patients with brain tumors. Neurosurgery 2002 0.75
42 Molecular imaging of cardiac sympathetic innervation by 11C-mHED and PET: from man to mouse? J Nucl Med 2010 0.75
43 Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation. J Med Chem 2013 0.75
44 Fluorinated isatin derivatives. Part 3. New side-chain fluoro-functionalized pyrrolidinyl sulfonyl isatins as potent caspase-3 and -7 inhibitors. Future Med Chem 2009 0.75
45 3-[123I]Iodo-L-alpha-methyl tyrosine transport into human fibroblasts and comparison with Ewing's sarcoma cells. Nucl Med Biol 2002 0.75
46 Development of PSMA-1007 - Related Series of F-Labeled Glu-ureido type PSMA inhibitors. J Med Chem 2020 0.75
47 Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ET(A) receptor radioligands. Bioorg Med Chem 2005 0.75
48 Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling. Org Biomol Chem 2013 0.75
49 Non-peptidyl (18)F-labelled PET tracers as radioindicators for the noninvasive detection of cancer. Recent Results Cancer Res 2013 0.75
50 Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7. Eur J Med Chem 2013 0.75
51 Correction to Novel Bispecific PSMA/GRPr Targeting Radioligands with Optimized Pharmacokinetics for Improved PET Imaging of Prostate Cancer. Bioconjug Chem 2016 0.75
52 Improving the imaging contrast of (68)Ga-PSMA-11 by targeted linker design: charged spacer moieties enhance the pharmacokinetic properties. Bioconjug Chem 2017 0.75
53 Efficient synthesis of a fluorine-18 labeled biotin derivative. Nucl Med Biol 2012 0.75
54 Early effects of irradiation on [(123)I]-IMT and [(18)F]-FDG uptake in rat C6 glioma cells. Strahlenther Onkol 2004 0.75
55 Molecular cardiovascular imaging using scintigraphic methods. Eur Radiol 2007 0.75