Published in Vaccine on July 09, 2016
Toll-like receptors. Annu Rev Immunol (2001) 26.06
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med (1991) 8.78
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med (2001) 8.60
Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol (2005) 3.75
Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol (2011) 3.32
Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med (2002) 2.96
Cross-priming in health and disease. Nat Rev Immunol (2010) 2.51
AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J Immunol (2009) 2.49
Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol (2012) 2.48
Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses. J Immunol (2003) 2.34
Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells. J Immunol (2005) 1.93
Reconstitution of diphtheria toxin from two nontoxic cross-reacting mutant proteins. Science (1972) 1.82
Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems. Expert Rev Vaccines (2011) 1.75
TLR7 and TLR8 as targets in cancer therapy. Oncogene (2008) 1.72
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets. Blood (2007) 1.67
Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis. Expert Rev Vaccines (2012) 1.62
Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies. J Hepatol (2007) 1.60
T cell anergy and costimulation. Immunol Rev (2003) 1.52
Topical resiquimod 0.01% gel decreases herpes simplex virus type 2 genital shedding: a randomized, controlled trial. J Infect Dis (2007) 1.37
Immunogenicity and tolerability of an AS03(A)-adjuvanted prepandemic influenza vaccine: a phase III study in a large population of Asian adults. Vaccine (2009) 1.30
Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases. Front Immunol (2013) 1.27
The use of Toll-like receptor 7/8 agonists as vaccine adjuvants. Expert Rev Vaccines (2013) 1.26
Influenza A virus infection of human primary dendritic cells impairs their ability to cross-present antigen to CD8 T cells. PLoS Pathog (2012) 1.14
Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness. J Leukoc Biol (2013) 1.13
Synthesis and structure-activity-relationships of 1H-imidazo[4,5-c]quinolines that induce interferon production. J Med Chem (2005) 1.06
The safety evaluation of adjuvants during vaccine development: the AS04 experience. Vaccine (2011) 1.04
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition. Mol Immunol (2009) 0.99
Antiviral applications of Toll-like receptor agonists. J Antimicrob Chemother (2012) 0.90
T cell responses: naive to memory and everything in between. Adv Physiol Educ (2013) 0.89
Co-incubation with IL-18 potentiates antigen-specific IFN-γ response in a whole-blood stimulation assay for measurement of cell-mediated immune responses in pigs experimentally infected with Lawsonia intracellularis. Vet Immunol Immunopathol (2010) 0.87
Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood (2011) 0.86
Viral vaccines and CTL response. J Biomed Biotechnol (2010) 0.84
Chemokine receptors and other surface molecules preferentially associated with human Th1 or Th2 cells. Microbes Infect (1999) 0.83
Imiquimod-elicited emesis is mediated by the area postrema, but not by direct neuronal activation. Brain Res Bull (2001) 0.78
Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives. Bioorg Med Chem Lett (2015) 0.78