Published in Front Oncol on June 27, 2016
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59
A severe combined immunodeficiency mutation in the mouse. Nature (1983) 13.99
Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J Immunol (1995) 5.75
The pediatric preclinical testing program: description of models and early testing results. Pediatr Blood Cancer (2007) 5.28
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science (2008) 3.39
Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood (2004) 3.13
Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol (2001) 2.71
Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer (2008) 2.45
Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood (1997) 2.33
Acute Lymphoblastic Leukemia in Children. N Engl J Med (2015) 2.33
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood (2005) 2.28
Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol (2009) 2.00
AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia (2010) 1.97
Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors. Leukemia (2003) 1.85
A robust xenotransplantation model for acute myeloid leukemia. Leukemia (2009) 1.67
beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function. Blood (2000) 1.62
A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science (1989) 1.60
Early relapse in ALL is identified by time to leukemia in NOD/SCID mice and is characterized by a gene signature involving survival pathways. Cancer Cell (2011) 1.21
Therapeutic potential of CD22-specific antibody-targeted chemotherapy using inotuzumab ozogamicin (CMC-544) for the treatment of acute lymphoblastic leukemia. Leukemia (2007) 1.21
Central nervous system disease in acute lymphoblastic leukemia: prophylaxis and treatment. Hematology Am Soc Hematol Educ Program (2006) 1.19
High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias. Leukemia (2010) 1.13
Good engraftment of B-cell precursor ALL in NOD-SCID mice. Klin Padiatr (1997) 1.12
Clinical significance of central nervous system involvement at diagnosis of pediatric acute myeloid leukemia: a single institution's experience. Leukemia (2003) 1.11
Leukemia propagating cells rebuild an evolving niche in response to therapy. Cancer Cell (2014) 1.07
Xenograft models for normal and malignant stem cells. Blood (2015) 1.01
Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia. J Clin Oncol (2015) 1.00
Diversity of human leukemia xenograft mouse models: implications for disease biology. Cancer Res (2011) 0.99
Mouse models with human immunity and their application in biomedical research. J Cell Mol Med (2008) 0.99
Frequency of leukemic initiating cells does not depend on the xenotransplantation model used. Leukemia (2011) 0.94
Stable and reproducible engraftment of primary adult and pediatric acute myeloid leukemia in NSG mice. Leukemia (2011) 0.94
Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis. Leuk Res (2011) 0.93
Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine. Mol Pharm (2012) 0.91
Xenograft models for the preclinical evaluation of new therapies in acute leukemia. Leuk Lymphoma (2007) 0.90
Engraftment of low numbers of pediatric acute lymphoid and myeloid leukemias into NOD/SCID/IL2Rcγnull mice reflects individual leukemogenecity and highly correlates with clinical outcome. Int J Cancer (2013) 0.89
Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease. Methods Mol Biol (2010) 0.88
Comparison of childhood leukemia initiating cell populations in NOD/SCID and NSG mice. Leukemia (2011) 0.86
Prognostic significance of the CD10+CD19+CD34+ B-progenitor immunophenotype in children with acute lymphoblastic leukemia: a report from the Children's Cancer Group. Leuk Lymphoma (1997) 0.86
Murine models of acute leukemia: important tools in current pediatric leukemia research. Front Oncol (2014) 0.84
Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling. Cell Death Dis (2012) 0.80
Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy. PLoS One (2015) 0.79
How animal models of leukaemias have already benefited patients. Mol Oncol (2013) 0.77