Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27472077)

Published in Invest Ophthalmol Vis Sci on July 01, 2016

Authors

Jeremy A Whitson1, David R Sell1, Michael C Goodman2, Vincent M Monnier3, Xingjun Fan1

Author Affiliations

1: Department of Pathology Case Western Reserve University, Cleveland, Ohio, United States.
2: Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States.
3: Department of Pathology Case Western Reserve University, Cleveland, Ohio, United States 3Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States.

Articles cited by this

Physiological properties of the normal lens. Physiol Rev (1997) 2.47

Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation. Am J Ophthalmol (2005) 2.15

Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther (2000) 1.78

Free and protein-bound glutathione in normal and cataractous human lenses. Biochem J (1970) 1.61

An impediment to glutathione diffusion in older normal human lenses: a possible precondition for nuclear cataract. Exp Eye Res (1998) 1.60

Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. Proc Natl Acad Sci U S A (1983) 1.45

Nuclear sclerotic cataract after vitrectomy for idiopathic epiretinal membranes causing macular pucker. Am J Ophthalmol (1991) 1.42

Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice. Invest Ophthalmol Vis Sci (2001) 1.29

Glutathione and its function in the lens--an overview. Exp Eye Res (1990) 1.24

Evisceration of mouse vitreous and retina for proteomic analyses. J Vis Exp (2011) 1.07

TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity. Am J Physiol Cell Physiol (2012) 1.04

Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1981) 0.94

[Is vitrectomy cataractogenic? Study of changes of the crystalline lens after surgery of retinal detachment]. J Fr Ophtalmol (1992) 0.92

Synthesis and characterization of the oxygen and desthio analogues of glutathione as dead-end inhibitors of glutathione S-transferase. Biochem Biophys Res Commun (1985) 0.91

In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain. J Cereb Blood Flow Metab (2008) 0.89

Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes. Biochemistry (Mosc) (2014) 0.88

Dynamic regulation of GSH synthesis and uptake pathways in the rat lens epithelium. Exp Eye Res (2009) 0.85

Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus. J Biol Chem (2014) 0.85

Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci (1995) 0.84

Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice. Mol Vis (2011) 0.83

The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis. PLoS One (2012) 0.83

Transport into brain of buthionine sulfoximine, an inhibitor of glutathione synthesis, is facilitated by esterification and administration of dimethylsulfoxide. Brain Res (1990) 0.82

Lenticular glutathione synthesis: rate-limiting factors in its regulation and decline. Curr Eye Res (1984) 0.82

Determination of glutathione, cysteine and N-acetylcysteine in rabbit eye tissues using high-performance liquid chromatography and post-column derivatization with 5,5'-dithiobis(2-nitrobenzoic acid). J Chromatogr A (1997) 0.82

Functional re-evaluation of the putative glutathione transporters, RcGshT and RsGshT. Yale J Biol Med (1998) 0.81

Activity loss of glutathione synthesis enzymes associated with human subcapsular cataract. Invest Ophthalmol Vis Sci (1993) 0.81

Antioxidant delivery pathways in the anterior eye. Biomed Res Int (2013) 0.80

The disposition and bioavailability of 35S-GSH from 35S-GSSG in BSS PLUS in rabbit ocular tissues. J Ocul Pharmacol Ther (2004) 0.79

Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells. Mol Cell Biochem (2006) 0.79

Properties of electrochemically active components in mammalian vitreous humor. Exp Eye Res (1997) 0.79

Modelling cortical cataractogenesis XXIV: uptake by the lens of glutathione injected into the rat. Mol Vis (1999) 0.78

Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res (1994) 0.77

Comparison of transport at the anterior and posterior surfaces of the calf lens. Exp Eye Res (1977) 0.77