Potential immunotherapeutic role of interleukin-2 and interleukin-12 combination in patients with hepatocellular carcinoma.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27508176)

Published in J Hepatocell Carcinoma on June 09, 2014

Authors

Abdulwahab Ali Gabeen1, Fatma Farag Abdel-Hamid1, Motawa Eisa El-Houseini2, Shadia Abdel-Hamid Fathy1

Author Affiliations

1: Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
2: Cancer Biology Department, National Cancer Institute (NCI), Cairo University, Cairo, Egypt.

Articles cited by this

CD4+ CD25+ suppressor T cells: more questions than answers. Nat Rev Immunol (2002) 12.73

Isolation of lymphocytes, granulocytes and macrophages. Scand J Immunol (1976) 7.06

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J Immunol (1988) 5.80

Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol (2007) 4.75

Increase of regulatory T cells in the peripheral blood of cancer patients. Clin Cancer Res (2003) 3.44

Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res (2005) 2.78

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol (2011) 2.44

FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res (2007) 2.21

Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood (2000) 1.60

Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma. J Hepatol (2006) 1.60

Interleukin 12 a key immunoregulatory cytokine in infection applications. Int J Mol Sci (2010) 1.41

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells. J Clin Invest (1996) 1.33

Regulation of inflammation by interleukin-4: a review of "alternatives". J Leukoc Biol (2012) 1.20

Hepatocellular carcinoma: natural history, current management, and emerging tools. Biologics (2012) 1.10

Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett (2011) 1.10

IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors. Cancer Cell Int (2011) 1.10

Hepatocellular carcinoma cell supernatants increase expansion and function of CD4(+)CD25(+) regulatory T cells. Lab Invest (2007) 1.06

IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance. Am J Respir Cell Mol Biol (2008) 1.00

HLA A2601-restricted CTLs recognize a peptide antigen expressed on squamous cell carcinoma. Cancer Res (1995) 0.95

Synergistic effects of IL-2, IL-12 and IL-18 on cytolytic activity, perforin expression and IFN-gamma production of porcine natural killer cells. Vet Immunol Immunopathol (2007) 0.94

IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells. Blood (2003) 0.92

Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model. J Immunol (2011) 0.91

Interferon-gamma produced by interleukin-12-activated tumor infiltrating CD8+T cells directly induces apoptosis of mouse hepatocellular carcinoma. J Hepatol (2006) 0.90

Tumor-infiltrating lymphocytes and hepatocellular carcinoma: pathology and clinical management. Int J Clin Oncol (2010) 0.90

Flow cytometry of fine-needle-aspiration biopsies: a new method to monitor the intrahepatic immunological environment in chronic viral hepatitis. J Viral Hepat (2005) 0.88

Effects of cytokines on in vitro growth of tumor-infiltrating lymphocytes obtained from human primary and metastatic liver tumors. Cancer Immunol Immunother (1991) 0.85

IL-4 selectively inhibits IL-2-triggered Stat5 activation, but not proliferation, in human T cells. J Immunol (1999) 0.84

Transfection of IL-2 and/or IL-12 genes into spleen in treatment of rat liver cancer. World J Gastroenterol (2004) 0.80

Monitoring intrahepatic CD8+ T cells by fine-needle aspiration cytology in chronic hepatitis C infection. J Viral Hepat (2004) 0.80

Effects of combined therapy with interleukin 2 and interleukin 12 gene-transfected tumor vaccine for head and neck carcinoma. Arch Otolaryngol Head Neck Surg (2003) 0.79

Clonal and functional analysis for the augmentation of tumour-infiltrating lymphocytes by interleukin 4. Br J Cancer (1996) 0.78

Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo. Cytokine (2004) 0.77

Effects of pulsing procedure of interleukin-12 in combination with interleukin-2 on the activation of peripheral blood lymphocytes derived from patients with hepatocellular carcinoma. Acta Med Okayama (2003) 0.77

Interleukin-12 augments cytolytic activity of peripheral blood mononuclear cells against autologous lung cancer cells in combination with IL-2. Lung Cancer (2002) 0.77

European Working Group on Clinical Cell Analysis (EWGCCA): 6 years on. J Biol Regul Homeost Agents (2003) 0.77

Expansion and activation of natural killer cells from PBMC for immunotherapy of hepatocellular carcinoma. World J Gastroenterol (2004) 0.76

Tumor-infiltrating lymphocytes and hepatocellular carcinoma. Int J Clin Oncol (2010) 0.76