Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27528462)

Published in Mol Psychiatry on August 16, 2016

Authors

S P Pantazatos1,2, Y-Y Huang1,2, G B Rosoklija1,2, A J Dwork2, V Arango1,2, J J Mann1,2

Author Affiliations

1: Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, NY, USA.
2: Department of Psychiatry, Columbia University, New York, NY, USA.

Articles citing this

Neuropathology of suicide: recent findings and future directions. Mol Psychiatry (2017) 0.75

Articles cited by this

Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods (2008) 126.81

A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61

The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51

A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat Genet (2011) 59.36

RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet (2009) 58.77

Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res (2003) 52.74

The transcriptional landscape of the yeast genome defined by RNA sequencing. Science (2008) 48.99

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc (2012) 35.75

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol (2014) 27.48

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly (Austin) (2012) 20.08

Software for computing and annotating genomic ranges. PLoS Comput Biol (2013) 8.20

Detecting differential usage of exons from RNA-seq data. Genome Res (2012) 6.34

The mystery and magic of glia: a perspective on their roles in health and disease. Neuron (2008) 5.32

ErmineJ: tool for functional analysis of gene expression data sets. BMC Bioinformatics (2005) 4.98

Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A (1998) 4.16

Hybridization interactions between probesets in short oligo microarrays lead to spurious correlations. BMC Bioinformatics (2006) 3.44

Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol (1994) 3.35

Sparse whole-genome sequencing identifies two loci for major depressive disorder. Nature (2015) 3.25

Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters. Arch Gen Psychiatry (2002) 2.76

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci (2014) 2.69

Research Domain Criteria: cognitive systems, neural circuits, and dimensions of behavior. Dialogues Clin Neurosci (2012) 2.45

Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry (2005) 2.41

Toward a universal microarray: prediction of gene expression through nearest-neighbor probe sequence identification. Nucleic Acids Res (2007) 2.39

Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta. Am J Hum Genet (2010) 2.27

Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. Front Genet (2012) 2.21

Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with clinician ante-mortem diagnosis. Acta Psychiatr Scand (1996) 2.13

Implication of SSAT by gene expression and genetic variation in suicide and major depression. Arch Gen Psychiatry (2006) 2.13

Molecular aging in human prefrontal cortex is selective and continuous throughout adult life. Biol Psychiatry (2005) 2.06

Pericellular proteases in angiogenesis and vasculogenesis. Arterioscler Thromb Vasc Biol (2006) 2.00

Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks. J Cereb Blood Flow Metab (2009) 1.97

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nat Med (2012) 1.97

Cytokines as mediators of depression: what can we learn from animal studies? Neurosci Biobehav Rev (2005) 1.89

Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One (2009) 1.78

The impact of multifunctional genes on "guilt by association" analysis. PLoS One (2011) 1.69

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun (2014) 1.67

Cell surface-associated proteins which bind native type IV collagen or gelatin. J Biol Chem (1984) 1.62

P4 ATPases - lipid flippases and their role in disease. Biochim Biophys Acta (2009) 1.50

Patterns of gene expression in the limbic system of suicides with and without major depression. Mol Psychiatry (2007) 1.47

The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology (2001) 1.46

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry (2007) 1.45

Low IL-8 is associated with anxiety in suicidal patients: genetic variation and decreased protein levels. Acta Psychiatr Scand (2014) 1.43

Linking phospholipid flippases to vesicle-mediated protein transport. Biochim Biophys Acta (2009) 1.34

Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmacology (2004) 1.33

Cell pathology in mood disorders. Semin Clin Neuropsychiatry (2002) 1.30

Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. J Neurosci (2007) 1.30

Gene expression profiling of major depression and suicide in the prefrontal cortex of postmortem brains. Neurosci Res (2007) 1.30

A functional SNP in the promoter of the SERPINH1 gene increases risk of preterm premature rupture of membranes in African Americans. Proc Natl Acad Sci U S A (2006) 1.27

Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets (2013) 1.26

Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression. Biol Psychiatry (2012) 1.25

Genome-wide methylation changes in the brains of suicide completers. Am J Psychiatry (2013) 1.25

ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. J Biol Chem (2011) 1.20

Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res (2011) 1.16

Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: potential role of chemokines in the developing CNS. Glia (2002) 1.14

Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab (2013) 1.13

The emerging era of genomic data integration for analyzing splice isoform function. Trends Genet (2014) 1.11

A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity. Brain Behav Immun (2012) 1.09

Human astrocytes: secretome profiles of cytokines and chemokines. PLoS One (2014) 1.05

Evidence for potential functionality of nuclearly-encoded humanin isoforms. Genomics (2009) 1.04

The neurobiology of suicide. Lancet Psychiatry (2014) 1.03

Meta-Analysis of Cytokines and Chemokines in Suicidality: Distinguishing Suicidal Versus Nonsuicidal Patients. Biol Psychiatry (2014) 1.00

Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry (1998) 0.99

Astrocytic abnormalities and global DNA methylation patterns in depression and suicide. Mol Psychiatry (2014) 0.99

Chemokines in angiogenesis. Curr Top Microbiol Immunol (2010) 0.97

Performance comparison of SNP detection tools with illumina exome sequencing data--an assessment using both family pedigree information and sample-matched SNP array data. Nucleic Acids Res (2014) 0.97

Sex differences in glutamate receptor gene expression in major depression and suicide. Mol Psychiatry (2015) 0.96

Unravelling the role of Humanin. Trends Mol Med (2004) 0.96

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET. Proc Natl Acad Sci U S A (2015) 0.96

An overview of serine proteases. Curr Protoc Protein Sci (2002) 0.95

The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. Cell Mol Neurobiol (2013) 0.95

Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide. Am J Med Genet B Neuropsychiatr Genet (2009) 0.94

Serotonin 2C receptors: suicide, serotonin, and runaway RNA editing. Neuroscientist (2003) 0.94

Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing. Mol Psychiatry (2013) 0.93

Structural and functional neuroimaging studies of the suicidal brain. Prog Neuropsychopharmacol Biol Psychiatry (2011) 0.92

Functions of microglia in the central nervous system--beyond the immune response. Neuron Glia Biol (2012) 0.92

The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [¹¹C]PBR28 PET study. Brain Behav Immun (2013) 0.92

A pilot genome wide association and gene expression array study of suicide with and without major depression. World J Biol Psychiatry (2011) 0.89

Blood-brain barrier promotes differentiation of human fetal neural precursor cells. Stem Cells (2009) 0.87

Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission. Sci Rep (2014) 0.85

Microglia of prefrontal white matter in suicide. J Neuropathol Exp Neurol (2014) 0.85

Altered chemokine levels in the cerebrospinal fluid and plasma of suicide attempters. Psychoneuroendocrinology (2012) 0.85

Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers. Int J Neuropsychopharmacol (2013) 0.83

Low vascular endothelial growth factor and interleukin-8 in cerebrospinal fluid of suicide attempters. Transl Psychiatry (2012) 0.83

Is there an empirical link between impulsivity and suicidality in bipolar disorders? A review of the current literature and the potential psychological implications of the relationship. Bipolar Disord (2013) 0.83

Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and downregulated in the thalamus and caudate nucleus of depressed suicides. Mol Psychiatry (2015) 0.81

Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in major depression and suicide. Neurobiol Dis (2015) 0.80

Executive function and suicidality: A systematic qualitative review. Clin Psychol Rev (2015) 0.78

Gene expression profiling of suicide completers. Eur Psychiatry (2010) 0.78

Genetics of disease: Associations with depression. Nature (2015) 0.78

Angiogenesis inhibition and depression in older men. J Psychiatry Neurosci (2014) 0.77

Lower serum levels of interleukin-6 in a population sample with symptoms of depression than in a population sample without symptoms of depression. Physiol Res (2009) 0.76

A meta-analysis of cytokines in suicidal behavior. Brain Behav Immun (2015) 0.76