Published in Am J Pathol on August 18, 2016
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (2003) 100.88
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature (2009) 8.44
SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol (2007) 6.89
Helping the CD8(+) T-cell response. Nat Rev Immunol (2004) 4.90
Global identification of modular cullin-RING ligase substrates. Cell (2011) 3.13
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling. Mol Cell Biol (2000) 3.04
A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. Nat Med (2005) 1.88
The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell (2012) 1.84
Neddylation plays an important role in the regulation of murine and human dendritic cell function. Blood (2013) 1.69
The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Res (2012) 1.45
Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. Clin Cancer Res (2010) 1.34
Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol (2015) 1.33
SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. Mol Cell Biol (1999) 1.32
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Cancer Res (2011) 1.31
From bytes to bedside: data integration and computational biology for translational cancer research. PLoS Comput Biol (2007) 1.27
RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27. Proc Natl Acad Sci U S A (2009) 1.16
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. PLoS One (2012) 1.15
Current and emerging strategies for the prevention of graft-versus-host disease. Nat Rev Clin Oncol (2014) 1.15
Protein post-translational modifications and regulation of pluripotency in human stem cells. Cell Res (2013) 1.12
Subcellular fate and off-target effects of siRNA, shRNA, and miRNA. Pharm Res (2011) 1.12
Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation. Neuron (2014) 1.10
A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway. J Biol Chem (2012) 1.07
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. J Clin Invest (2014) 1.04
Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radic Biol Med (2010) 0.99
A new look at T cell receptor signaling to nuclear factor-κB. Trends Immunol (2013) 0.97
Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein. Free Radic Biol Med (1999) 0.96
Inhibition of neddylation represses lipopolysaccharide-induced proinflammatory cytokine production in macrophage cells. J Biol Chem (2012) 0.94
Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling. Proc Natl Acad Sci U S A (2012) 0.92
Neddylation pathway regulates the proliferation and survival of macrophages. Biochem Biophys Res Commun (2013) 0.90
Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. Oncogene (2013) 0.88
Graft-versus-host disease. Panminerva Med (2010) 0.86