Cellular transduction mechanisms of adeno-associated viral vectors.

ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES. Science (1965) 9.77

Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther (2001) 4.35

Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J Virol (2000) 3.84

Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses. Proc Natl Acad Sci U S A (2008) 3.84

High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors. Mol Ther (2008) 2.93

Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. J Virol (2002) 2.77

Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation. J Virol (2001) 2.56

Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res (2011) 2.56

The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity. J Gen Virol (2002) 2.44

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A (2009) 2.37

Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation. J Virol (2000) 2.08

Dynamin is required for recombinant adeno-associated virus type 2 infection. J Virol (1999) 1.99

Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression. Virology (2008) 1.96

Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression. Proc Natl Acad Sci U S A (1997) 1.91

A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini. J Virol (2005) 1.79

Adeno-associated virus type 2-mediated gene transfer: correlation of tyrosine phosphorylation of the cellular single-stranded D sequence-binding protein with transgene expression in human cells in vitro and murine tissues in vivo. J Virol (1998) 1.77

Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus. J Virol (2006) 1.76

An essential receptor for adeno-associated virus infection. Nature (2016) 1.69

Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia. J Virol (2004) 1.62

AAV transcytosis through barrier epithelia and endothelium. Mol Ther (2005) 1.60

Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus. J Virol (2008) 1.50

The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J Virol (2007) 1.46

Host cell DNA repair pathways in adeno-associated viral genome processing. J Virol (2006) 1.43

Endocytosis of adeno-associated virus type 5 leads to accumulation of virus particles in the Golgi compartment. J Virol (2002) 1.35

Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly. J Virol (2006) 1.33

Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome. J Virol (2001) 1.29

rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion. Mol Ther (2006) 1.28

A 110-kDa nuclear shuttle protein, nucleolin, specifically binds to adeno-associated virus type 2 (AAV-2) capsid. Virology (1999) 1.25

Enhancing transduction of the liver by adeno-associated viral vectors. Gene Ther (2008) 1.24

Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction. J Virol (2010) 1.21

Adeno-associated virus interactions with B23/Nucleophosmin: identification of sub-nucleolar virion regions. Virology (2006) 1.21

Adeno-associated virus vectorology, manufacturing, and clinical applications. Methods Enzymol (2012) 1.19

Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway. Cell Host Microbe (2011) 1.19

Effects of adeno-associated virus DNA hairpin structure on recombination. J Virol (2005) 1.15

Helper functions required for wild type and recombinant adeno-associated virus growth. Curr Gene Ther (2005) 1.14

Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions. J Virol (2007) 1.08

Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking. J Virol (2011) 1.04

Early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking. J Virol (2009) 1.01

Long-distance axonal transport of AAV9 is driven by dynein and kinesin-2 and is trafficked in a highly motile Rab7-positive compartment. Mol Ther (2013) 0.97

Heat-shock treatment-mediated increase in transduction by recombinant adeno-associated virus 2 vectors is independent of the cellular heat-shock protein 90. J Biol Chem (2004) 0.95

Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles. Virology (2010) 0.94

Quantitative 3D tracing of gene-delivery viral vectors in human cells and animal tissues. Mol Ther (2011) 0.94

Evidence for pH-dependent protease activity in the adeno-associated virus capsid. J Virol (2012) 0.93

Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus. J Virol (2014) 0.93

Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression. Gynecol Oncol (2012) 0.90

Parvovirus glycan interactions. Curr Opin Virol (2014) 0.90

Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes. J Virol (2013) 0.88

Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction. J Virol (2014) 0.87

Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complex. J Virol (2014) 0.87

AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. PLoS Pathog (2011) 0.87

Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release. J Virol (2012) 0.87

Recombinant adeno-associated virus utilizes cell-specific infectious entry mechanisms. J Virol (2014) 0.84

Arsenic trioxide stabilizes accumulations of adeno-associated virus virions at the perinuclear region, increasing transduction in vitro and in vivo. J Virol (2013) 0.84

Mechanistic insights into the enhancement of adeno-associated virus transduction by proteasome inhibitors. J Virol (2013) 0.82

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. PLoS Pathog (2015) 0.81

Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses. Hum Gene Ther Methods (2016) 0.78

Super-resolution imaging of nuclear import of adeno-associated virus in live cells. Mol Ther Methods Clin Dev (2015) 0.77

Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. J Biol Chem (2015) 0.77