Published in J Med Chem on August 01, 1989
Simple agarose gel electrophoretic method for the identification and characterization of plasmid deoxyribonucleic acid. J Bacteriol (1976) 43.93
Plasmid-linked ampicillin resistance in haempohilus influenza type b. Infect Immun (1975) 8.68
Plasmid-mediated factors associated with virulence of bacteria to animals. Annu Rev Microbiol (1980) 4.05
Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae. Antimicrob Agents Chemother (1977) 4.02
Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae. J Bacteriol (1977) 3.76
Molecular nature of two beta-lactamase-specifying plasmids isolated from Haemophilus influenzae type b. J Bacteriol (1976) 3.03
Plasmodium berghei dihydrofolate reductase. Isolation, properties, and inhibition by antifolates. Mol Pharmacol (1969) 2.46
Relationships among some R plasmids found in Haemophilus influenzae. J Bacteriol (1977) 2.34
Identification of Harper-Cawston factor as thymidine phosphorylase and removal from media of substances interfering with susceptibility testing to sulfonamides and diaminopyrimidines. Antimicrob Agents Chemother (1975) 2.22
Protein expression in Escherichia coli minicells containing recombinant plasmids specifying trimethoprim-resistant dihydrofolate reductases. J Bacteriol (1980) 1.99
Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science (1997) 1.73
Dihydrofolate reductase: thymidylate synthase, a bifunctional polypeptide from Crithidia fasciculata. Proc Natl Acad Sci U S A (1980) 1.71
Monitoring of plasmid-encoded, trimethoprim-resistant dihydrofolate reductase genes: detection of a new resistant enzyme. Antimicrob Agents Chemother (1982) 1.67
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase. J Med Chem (1989) 1.64
Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man. Drug Metab Dispos (1978) 1.61
Dihydrofolate reductase from pyrimethamine-resistant Plasmodium berghei. J Biol Chem (1970) 1.48
beta-lactamases and R-plasmids of Haemophilus influenzae. Scand J Infect Dis Suppl (1978) 1.48
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase. J Biol Chem (1979) 1.47
Ecological conceptual models: a framework and case study on ecosystem management for South Florida sustainability. Sci Total Environ (2001) 1.44
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine. J Med Chem (1980) 1.41
Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U). Antimicrob Agents Chemother (1987) 1.41
Immunological detection of nucleic acids and antibodies to nucleic acids and nuclear antigens by counterimmunoelectrophoresis. Clin Exp Immunol (1974) 1.39
Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding. J Biol Chem (1981) 1.39
Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product. J Biol Chem (1985) 1.38
Folate metabolism in malaria. Bull World Health Organ (1977) 1.33
Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica. J Org Chem (1973) 1.32
Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67. Biochemistry (1986) 1.29
Dihydrofolate reductase hysteresis and its effect of inhibitor binding analyses. Biochemistry (1981) 1.26
Cost effectiveness of interferon alpha or peginterferon alpha with ribavirin for histologically mild chronic hepatitis C. Gut (2005) 1.24
Common plasmid specifying tobramycin resistance found in two enteric bacteria isolated from burn patients. Antimicrob Agents Chemother (1978) 1.23
R plasmid dihydrofolate reductase with subunit structure. J Biol Chem (1979) 1.22
The enzymic synthesis of dihydropteroate and dihydrofolate by Plasmodium berghei. J Protozool (1973) 1.22
Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells. Antimicrob Agents Chemother (1994) 1.18
alpha-Carboxyl-linked glutamates in the folylpolyglutamates of Escherichia coli. J Biol Chem (1986) 1.17
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. J Med Chem (1996) 1.17
Molecular mechanisms of resistance to trimethoprim. Rev Infect Dis (1982) 1.16
Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay. J Infect Dis (1973) 1.09
Escherichia coli dihydrofolate reductase: isolation and characterization of two isozymes. Biochemistry (1977) 1.09
Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites. J Biol Chem (1994) 1.09
In vitro cleavable-complex assay to monitor antimicrobial potency of quinolones. Antimicrob Agents Chemother (1988) 1.08
X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex. J Biol Chem (1997) 1.08
Inhibition of dihydrofolate reductase: effect of reduced nicotinamide adenine dinucleotide phosphate on the selectivity and affinity of diaminobenzylpyrimidines. Biochemistry (1982) 1.06
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 5. 3',5'-Dimethoxy-4'-substituted-benzyl analogues of trimethoprim. J Med Chem (1981) 1.05
Microculture screening assay for primary in vitro evaluation of drugs against Pneumocystis carinii. Antimicrob Agents Chemother (1991) 1.04
X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor. J Med Chem (2001) 1.04
In vitro synthesis of alpha-carboxyl-linked folylpolyglutamates by an enzyme preparation from Escherichia coli. J Biol Chem (1986) 1.02
Cloning, purification, and properties of Candida albicans thymidylate synthase. J Bacteriol (1989) 1.02
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes. J Med Chem (1987) 1.01
The isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica. J Org Chem (1975) 1.00
Primary localized conjunctival amyloidosis presenting with recurrence of subconjunctival hemorrhage. Am J Ophthalmol (2000) 1.00
Isolation of a dihydrofolate reductase-deficient mutant of Escherichia coli. J Bacteriol (1985) 0.99
Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines. J Med Chem (1985) 0.99
Outcome of lacrimal surgery in older patients. Can J Ophthalmol (2000) 0.98
Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. J Am Chem Soc (1976) 0.97
In vitro and in vivo efficacy of the combination trimethoprim-sulfamethoxazole against clinical isolates of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (1986) 0.97
Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100. J Bacteriol (1991) 0.96
Characterization of an R-plasmid dihydrofolate reductase with a monomeric structure. J Biol Chem (1984) 0.96
Estimating adult HIV prevalence in the UK in 2003: the direct method of estimation. Sex Transm Infect (2006) 0.95
Pyrrolo[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines as conformationally restricted analogues of the antibacterial agent trimethoprim. Bioorg Med Chem (1996) 0.93
Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines. J Med Chem (1995) 0.93
Nucleotide sequence of the Escherichia coli uridine phosphorylase (udp) gene. Nucleic Acids Res (1989) 0.92
Altered dihydrofolate reductase associated with drug-resistance transfer between rodent plasmodia. Science (1970) 0.91
High-performance liquid chromatographic assay for the simultaneous measurement of trimethoprim and sulfamethoxazole in plasma or urine. Ther Drug Monit (1990) 0.89
Characterization and amino acid sequence of Neisseria gonorrhoeae dihydrofolate reductase. J Biol Chem (1984) 0.88
Pharmacokinetics of trimethoprim and sulfadiazine in the dog: urine concentrations after oral administration. Am J Vet Res (1981) 0.88
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. J Med Chem (1985) 0.86
Refolding of recombinant Pneumocystis carinii dihydrofolate reductase and characterization of the enzyme. Protein Expr Purif (1993) 0.86
Metabolism and disposition by the rat of 35S-sulfadiazine alone and in the presence of trimethoprim. Drug Metab Dispos (1979) 0.85
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. J Med Chem (1982) 0.84
Molecular cloning and characterization of rat brain 2',3'-cyclic nucleotide 3'-phosphodiesterase isoform 2. J Neurosci Res (1994) 0.84
Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res (1993) 0.83
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. J Med Chem (1992) 0.82
Folic acid does not inactivate xanthine oxidase. J Biol Chem (1984) 0.81
2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 9. Lipophilic trimethoprim analogues as antigonococcal agents. J Med Chem (1988) 0.81
Kinetics of methotrexate binding to dihydrofolate reductase from Neisseria gonorrhoeae. Biochem Pharmacol (1984) 0.80
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. J Med Chem (1991) 0.80
Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid. Cancer Res (1995) 0.80
Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives. J Med Chem (1994) 0.80
Recent infection testing algorithm (RITA) applied to new HIV diagnoses in England, Wales and Northern Ireland, 2009 to 2011. Euro Surveill (2014) 0.79
Inhibition of dihydrofolate synthetase by folate, homofolate, pteroate and homopteroate and their reduced forms. Biochim Biophys Acta (1976) 0.79
Diphtheria toxin: evidence for presence of fragment B in corynebacteriophage. Biochem Biophys Res Commun (1972) 0.79
alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil. Biochem Pharmacol (2000) 0.79
Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datisca glomerata. J Org Chem (1973) 0.79
Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid. J Med Chem (1991) 0.79
Tumor inhibitors. LXV. Bersenogenin, berscillogenin, and 3-epiberscillogenin, three new cytotoxic bufadienolides from Bersama abyssinica. J Org Chem (1971) 0.79
Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics: allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans. Cancer Chemother Pharmacol (1997) 0.79
Methotrexate therapy for P vivax malaria. JAMA (1971) 0.79
A microbiological assay for sodium azide. Anal Biochem (1980) 0.79
Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle. Res Vet Sci (1993) 0.78
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil. Cancer Res (1995) 0.78
Amiloride intercalates into DNA and inhibits DNA topoisomerase II. J Biol Chem (1987) 0.78