Alternatives, and adjuncts, to prophylactic platelet transfusion for people with haematological malignancies undergoing intensive chemotherapy or stem cell transplantation.

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Published in Cochrane Database Syst Rev on August 22, 2016

Authors

Michael Desborough1, Lise J Estcourt, Carolyn Doree, Marialena Trivella, Sally Hopewell, Simon J Stanworth, Michael F Murphy

Author Affiliations

1: Haematology/Transfusion Medicine, NHS Blood and Transplant, Oxford, UK.

Associated clinical trials:

A Pilot Study of a Thrombopoietin-Receptor Agonist (TPO-R Agonist), Eltrombopag, in Aplastic Anemia Patients With Immunosuppressive-Therapy Refractory Thrombocytopenia | NCT00922883

Eltrombopag Treatment of Thrombocytopenia in Subjects With Advanced Myelodysplastic Syndrome (MDS) or Secondary Acute Myeloid Leukemia After MDS (sAML/MDS) | NCT00903422

Romiplostim Treatment of Thrombocytopenia in Subjects With Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) | NCT00614523

Safety and Efficacy Study for Solid Tumor Patients Treated With Eltrombopag | NCT01147809

SB-497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adult Cancer Patients Receiving Chemotherapy | NCT00102726

Dose Finding Study Of Oral Eltrombopag In Patients With Sarcoma Receiving Adriamycin And Ifosfamide | NCT00358540

Determination of Safe Dose of Romiplostim (AMG 531) in Patients With Myelodysplastic Syndromes (MDS) | NCT00303472

Dose/ Schedule Finding Trial of Romiplostim for Chemotherapy-Induced Thrombocytopenia (CIT) in Non-Small Cell Lung Cancer (NSCLC) | NCT00413283

Study of Romiplostim for Chemotherapy Induced Thrombocytopenia | NCT02052882

A Phase 2 Study to Evaluate the Efficacy and Safety of AMG531 in Aplastic Anemia | NCT02094417

Study of AMG 531 to Evaluate the Safety & Efficacy in Patients With Non-Hodgkin's Lymphoma | NCT00299182

A Rollover Study to Provide Continued Treatment With Eltrombopag | NCT01957176

Study In Healthy Subjects To Evaluate The Photo-Irritant Potential Of Eltrombopag | NCT00688272

Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation and Food Effect | NCT01072162

Eltrombopag for Moderate Aplastic Anemia | NCT01328587

Eltrombopag for Enhancing Platelet Engraftment in Adult Patients Undergoing Cord Blood Transplantation | NCT01757145

Trial of Eltrombopag During Consolidation Therapy in Adults With AML in Complete Remission (PrE0901) | NCT01656252

Eltrombopag for Post Transplant Thrombocytopenia | NCT01000051

Safety of Romiplostim (Nplate®) Following UCBT | NCT02046291

A Pilot Study of Oral Vorinostat Plus Oral Eltrombopag Support in Patients With Lymphoma (VEIL) (VEIL) | NCT01500538

A Study of Eltrombopag in Patients With CMML and Thrombocytopenia | NCT02323178

Phase II Eltrombopag in Chronic Lymphocytic Leukemia (CLL) | NCT01168921

A Randomized Placebo-controlled Phase 2 Study of Decitabine With or Without Eltrombopag in AML Patients (DELTA) | NCT02446145

Secondary Prophylaxis in Non-Hodgkin Lymphoma (NHL) and Chemotherapy-induced Thrombocytopenia (ProRom) | NCT01516619

Using ROMIPLOSTINE for Persistent Thrombocytopenia With Transfusion-dependent Patients Who Received Allogeneic Hematopoietic Stem Cell (AGRAH003) | NCT01980030

A Randomized, Double Blind, Placebo-controlled Study to Assess the Efficacy and Safety of Eltrombopag as a Rescue of Isolated Chemotherapy-induced Thrombocytopenia in Patients With Gynecologic Cancer | NCT02093325

Eltrombopag in Thrombocytopenic Chronic Lymphocytic Leukemia (CLL) Patients (CLL2S Study of GCLLSG) | NCT01397149

Evaluating the Safety of Long Term Dosing of Romiplostim (Formerly AMG 531) in Thrombocytopenic Subjects With Myelodysplastic Syndromes (MDS) | NCT00472290

Study of Eltrombopag in Platelet Refractory Thrombocytopenia | NCT01194167

Eltrombopag Olamine in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia | NCT01550185

Eltrombopag in Patients With Delayed Post Transplant Thrombocytopenia. (ITP0511) | NCT01791101

Eltrombopag With or Without Hypomethylating Agent After Hypomethylating Agent Failure For Patients With Myelodysplastic Syndrome (MDS) | NCT01893372

A Safety and Efficacy Study of Eltrombopag in Subjects With AML | NCT01890746

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