High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.

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🔗 View Article (PMID 27562257)

Published in Nat Microbiol on July 04, 2016

Authors

Shinsaku Okai1, Fumihito Usui1, Shuhei Yokota1, Yusaku Hori-I1, Makoto Hasegawa2, Toshinobu Nakamura3, Manabu Kurosawa4, Seiji Okada5, Kazuya Yamamoto6, Eri Nishiyama6, Hiroshi Mori6, Takuji Yamada6, Ken Kurokawa7,8,9, Satoshi Matsumoto10, Masanobu Nanno10, Tomoaki Naito10, Yohei Watanabe10, Tamotsu Kato11, Eiji Miyauchi11, Hiroshi Ohno12, Reiko Shinkura1,13

Author Affiliations

1: Department of Immunology, Nagahama Institute of Bioscience and Technology, Nagahama, Shiga 526-0829, Japan.
2: Department of Protein Function Analysis, Nagahama Institute of Bioscience and Technology, Nagahama, Shiga 526-0829, Japan.
3: Department of Epigenetics, Nagahama Institute of Bioscience and Technology, Nagahama, Shiga 526-0829, Japan.
4: Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606-8501, Japan.
5: Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, Kumamoto 860-0811, Japan.
6: Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Tokyo 152-8550, Japan.
7: Department of Biological Information, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.
8: Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.
9: National Institute of Genetics, Center for Information Biology, Yata 1111, Mishima, Shizuoka 411-8540, Japan.
10: Yakult Central Institute, Tokyo 186-8650, Japan.
11: RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa 230-0045, Japan.
12: Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
13: PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan.