The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia.

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Published in Nat Microbiol on July 11, 2016

Authors

Carrie A Cowardin1, Erica L Buonomo2, Mahmoud M Saleh2, Madeline G Wilson2, Stacey L Burgess2, Sarah A Kuehne3, Carsten Schwan4, Anna M Eichhoff5, Friedrich Koch-Nolte5, Dena Lyras6, Klaus Aktories4, Nigel P Minton3, William A Petri2,7,8

Author Affiliations

1: Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA.
2: Departments of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908 USA.
3: Clostridia Research Group, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
4: Institute of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany.
5: Institute of Immunology, University Medical Center Hamburg-Eppendorf, D20246 Hamburg, Germany.
6: Department of Microbiology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, and Monash University, Victoria 3800, Australia.
7: Departments of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908 USA.
8: Departments of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

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