Published in Sci Rep on August 31, 2016
A synthetic oscillatory network of transcriptional regulators. Nature (2000) 24.58
Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements. Nucleic Acids Res (1997) 13.15
Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science (1996) 9.34
Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities. Nat Biotechnol (2006) 8.38
A synthetic multicellular system for programmed pattern formation. Nature (2005) 6.93
The TetR family of transcriptional repressors. Microbiol Mol Biol Rev (2005) 6.02
Combinatorial synthesis of genetic networks. Science (2002) 5.91
Detailed map of a cis-regulatory input function. Proc Natl Acad Sci U S A (2003) 4.30
Directed evolution of a genetic circuit. Proc Natl Acad Sci U S A (2002) 4.26
Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'. Nature (2010) 3.69
Non-specific DNA binding of genome regulating proteins as a biological control mechanism: I. The lac operon: equilibrium aspects. Proc Natl Acad Sci U S A (1974) 3.45
Interaction of effecting ligands with lac repressor and repressor-operator complex. Biochemistry (1975) 2.41
BioLogic gates enable logical transcription control in mammalian cells. Biotechnol Bioeng (2004) 1.97
Parameter estimation and model selection in computational biology. PLoS Comput Biol (2010) 1.91
Synthetic biology: understanding biological design from synthetic circuits. Nat Rev Genet (2009) 1.70
Understanding gene circuits at cell-fate branch points for rational cell reprogramming. Trends Genet (2010) 1.67
A synthetic time-delay circuit in mammalian cells and mice. Proc Natl Acad Sci U S A (2007) 1.59
An Introduction to Model Selection. J Math Psychol (2000) 1.54
Phenotypes and tolerances in the design space of biochemical systems. Proc Natl Acad Sci U S A (2009) 1.44
Binding of E.coli lac repressor to non-operator DNA. Nucleic Acids Res (1977) 1.22
Molecular mechanisms of multiple toxin-antitoxin systems are coordinated to govern the persister phenotype. Proc Natl Acad Sci U S A (2013) 1.22
Quantifying global tolerance of biochemical systems: design implications for moiety-transfer cycles. PLoS Comput Biol (2009) 1.17
Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Lett (2009) 1.06
Mapping differentiation under mixed culture conditions reveals a tunable continuum of T cell fates. PLoS Biol (2013) 1.04
Modeling and simulation: tools for metabolic engineering. J Biotechnol (2002) 0.98
Phenotypic repertoire of the FNR regulatory network in Escherichia coli. Mol Microbiol (2010) 0.97
Limitations of quantitative gene regulation models: a case study. Genome Res (2003) 0.96
Automated construction and analysis of the design space for biochemical systems. Bioinformatics (2010) 0.95
Strategy revealing phenotypic differences among synthetic oscillator designs. ACS Synth Biol (2014) 0.88
A bistable hysteretic switch in an activator-repressor regulated restriction-modification system. Nucleic Acids Res (2013) 0.87
Regulatory design governing progression of population growth phases in bacteria. PLoS One (2012) 0.87
Phenotypic deconstruction of gene circuitry. Chaos (2013) 0.87
Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire. NPJ Syst Biol Appl (2015) 0.83
Tet repressor-tetracycline interaction. J Protein Chem (1996) 0.81
Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems. Front Genet (2016) 0.76