Published in Sci Rep on September 01, 2016
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis. Sci Rep (2017) 0.75
Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hemolysin to Hemolytic Activity and Ion-Channel Opening. Toxins (Basel) (2017) 0.75
Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum. J Cell Biol (1982) 14.41
Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis. EMBO J (1988) 4.75
SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments. Comput Appl Biosci (1995) 4.09
Calmodulin activates prokaryotic adenylate cyclase. Proc Natl Acad Sci U S A (1980) 3.83
Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll motif. EMBO J (1993) 2.80
Salt bridge stability in monomeric proteins. J Mol Biol (1999) 2.79
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin. Infect Immun (1988) 2.69
RTX proteins: a highly diverse family secreted by a common mechanism. FEMS Microbiol Rev (2010) 2.13
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18). J Exp Med (2001) 2.12
Interaction of Bordetella pertussis adenylate cyclase with calmodulin. Identification of two separated calmodulin-binding domains. J Biol Chem (1988) 1.97
Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation. J Bacteriol (1991) 1.90
Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis. Science (1994) 1.78
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J Immunol (2010) 1.48
Bordetella adenylate cyclase toxin: a swift saboteur of host defense. Curr Opin Microbiol (2006) 1.47
Adenylate cyclase toxin (CyaA) of Bordetella pertussis. Evidence for the formation of small ion-permeable channels and comparison with HlyA of Escherichia coli. J Biol Chem (1994) 1.41
Deletions affecting hemolytic and toxin activities of Bordetella pertussis adenylate cyclase. Infect Immun (1990) 1.41
Accurate secondary structure prediction and fold recognition for circular dichroism spectroscopy. Proc Natl Acad Sci U S A (2015) 1.40
Complex salt bridges in proteins: statistical analysis of structure and function. J Mol Biol (1995) 1.37
Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes. Translocation of the toxin across the membrane. J Biol Chem (1992) 1.35
Interaction of calcium with Bordetella pertussis adenylate cyclase toxin. Characterization of multiple calcium-binding sites and calcium-induced conformational changes. J Biol Chem (1995) 1.33
RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion. J Biol Chem (2008) 1.27
High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection. Infect Immun (2006) 1.26
Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes. Infect Immun (2006) 1.25
Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP! Mol Microbiol (2006) 1.24
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin. EMBO J (2005) 1.22
Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin. J Biol Chem (1998) 1.19
Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: implication for the in vivo delivery of CD8(+) T cell epitopes into antigen-presenting cells. Proc Natl Acad Sci U S A (1998) 1.19
Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites. Infect Immun (2000) 1.15
Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli. J Biol Chem (1995) 1.10
Adenylate cyclase toxin from Bordetella pertussis. The relationship between induction of cAMP and hemolysis. J Biol Chem (1991) 1.06
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin. J Mol Biol (2010) 1.03
An amphipathic alpha-helix including glutamates 509 and 516 is crucial for membrane translocation of adenylate cyclase toxin and modulates formation and cation selectivity of its membrane channels. J Biol Chem (1999) 1.01
Identification by in vitro complementation of regions required for cell-invasive activity of Bordetella pertussis adenylate cyclase toxin. Mol Microbiol (1995) 0.99
Vibrio vulnificus biotype 3 multifunctional autoprocessing RTX toxin is an adenylate cyclase toxin essential for virulence in mice. Infect Immun (2014) 0.99
Acylation of lysine 860 allows tight binding and cytotoxicity of Bordetella adenylate cyclase on CD11b-expressing cells. Biochemistry (2005) 0.98
Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis. J Bacteriol (2001) 0.94
Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin. J Biol Chem (1995) 0.94
The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status. J Biol Chem (1999) 0.92
Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin. J Biol Chem (2007) 0.92
Molecular crowding stabilizes both the intrinsically disordered calcium-free state and the folded calcium-bound state of a repeat in toxin (RTX) protein. J Am Chem Soc (2013) 0.90
Calcium-Driven Folding of RTX Domain β-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts. Mol Cell (2016) 0.88
Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin. J Biol Chem (2012) 0.88
Adenylate cyclase toxin translocates across target cell membrane without forming a pore. Mol Microbiol (2010) 0.88
Characterization of a membrane-active peptide from the Bordetella pertussis CyaA toxin. J Biol Chem (2013) 0.88
Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size. Infect Immun (2013) 0.86
Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer. Proc Natl Acad Sci U S A (2013) 0.84
Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion. Sci Rep (2015) 0.84
Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form. J Biol Chem (2014) 0.83
Channel formation in model membranes by the adenylate cyclase toxin of Bordetella pertussis: effect of calcium. Biochemistry (2003) 0.83
Interdomain Contacts and the Stability of Serralysin Protease from Serratia marcescens. PLoS One (2015) 0.82
Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme. Pathog Dis (2015) 0.82
Different structural requirements for adenylate cyclase toxin interactions with erythrocyte and liposome membranes. Biochim Biophys Acta (2004) 0.80
Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3. Elife (2015) 0.80
Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin. Anal Biochem (2014) 0.79
Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domain. Infect Immun (2012) 0.79
Rearranging and concatenating a native RTX domain to understand sequence modularity. Protein Eng Des Sel (2012) 0.78
Functional importance of the Gly cluster in transmembrane helix 2 of the Bordetella pertussis CyaA-hemolysin: Implications for toxin oligomerization and pore formation. Toxicon (2015) 0.77
NMR assignment of intrinsically disordered self-processing module of the FrpC protein of Neisseria meningitidis. Biomol NMR Assign (2015) 0.77
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes. Cell Microbiol (2015) 0.77
Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8(+) and CD4(+) T cells. Immunol Cell Biol (2015) 0.77
Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin. Pathog Dis (2016) 0.76