Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants.

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Published in PLoS One on September 01, 2016

Authors

Gavin Churchyard1,2,3, Koleka Mlisana4, Shelly Karuna5, Anna-Lise Williamson6, Carolyn Williamson6, Lynn Morris7, Georgia D Tomaras8, Stephen C De Rosa5,9, Peter B Gilbert5, Niya Gu5, Chenchen Yu5, Nonhlanhla N Mkhize7, Tandile Hermanus7, Mary Allen10, Michael Pensiero10, Susan W Barnett11, Glenda Gray12,13, Linda-Gail Bekker14, David C Montefiori15, James Kublin5, Lawrence Corey5,9

Author Affiliations

1: Aurum Institute for Health Research, Klerksdorp, South Africa.
2: School of Public Health, University of Witwatersrand, Johannesburg, South Africa.
3: Advancing Care and Treatment for TB and HIV, Medical Research Council Collaborating Centre, Klerksdorp, South Africa.
4: University of Kwa-Zulu Natal, Durban, South Africa.
5: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
6: Institute of Infectious Disease and Molecular Medicine, Division of Medical Virology, University of Cape Town, Cape Town, South Africa; National Health Laboratory Services, Observatory, Cape Town, South Africa.
7: National Institute for Communicable Diseases, National Health Laboratory Services, Sandringham, Johannesburg, South Africa.
8: Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC, United States of America.
9: Department of Laboratory Medicine, University of Washington, Seattle, WA, United States of America.
10: Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America.
11: Novartis Vaccines and Diagnostics, Cambridge, MA, United States of America.
12: South African Medical Research Council, Cape Town, South Africa.
13: Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Braamfontein, Johannesburg, South Africa.
14: Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
15: Laboratory for AIDS Vaccine Research and Development, Duke University Medical Center, Durham, NC, United States of America.

Associated clinical trials:

Safety of and Immune Response to a DNA HIV Vaccine Boosted With a Modified Vaccinia HIV Vaccine and Protein HIV Vaccine in Healthy Adults | NCT01418235

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