Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron (2017) 0.80

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. PLoS Med (2017) 0.75

TREM2 in Neurodegenerative Diseases. Mol Neurodegener (2017) 0.75

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Front Aging Neurosci (2017) 0.75

Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Mol Biol Cell (2017) 0.75

"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res (1975) 301.74

PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92

Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics (2009) 190.94

The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res (2010) 97.51

Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03

The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology (1993) 47.72

Rare-variant association testing for sequencing data with the sequence kernel association test. Am J Hum Genet (2011) 18.88

Classification of primary progressive aphasia and its variants. Neurology (2011) 11.82

TREM2 variants in Alzheimer's disease. N Engl J Med (2012) 11.35

Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature (2012) 8.10

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol (2014) 5.61

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J Neurosci (2014) 5.52

Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet (2012) 5.48

The future of association studies: gene-based analysis and replication. Am J Hum Genet (2004) 5.44

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet (2002) 4.06

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. JAMA Neurol (2013) 3.70

The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. Neurology (2005) 2.77

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell (2015) 2.15

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med (2014) 2.05

A novel protective prion protein variant that colocalizes with kuru exposure. N Engl J Med (2009) 1.53

Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cogn Behav Neurol (2005) 1.48

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46

Coding variants in TREM2 increase risk for Alzheimer's disease. Hum Mol Genet (2014) 1.36

Heterozygous TREM2 mutations in frontotemporal dementia. Neurobiol Aging (2013) 1.23

Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS. Neurobiol Dis (2005) 1.14

Handedness and language learning disability differentially distribute in progressive aphasia variants. Brain (2013) 1.13

The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease. PLoS Genet (2015) 1.08

Effective filtering strategies to improve data quality from population-based whole exome sequencing studies. BMC Bioinformatics (2014) 1.06

Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family. Neurobiol Aging (2013) 1.04

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). J Biol Chem (2015) 1.04

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status. Acta Neuropathol (2016) 1.03

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. J Biol Chem (2015) 1.03

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron (2016) 1.01

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus. Traffic (2015) 0.99

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nat Rev Neurosci (2016) 0.97

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron (2016) 0.92

TREM2 in CNS homeostasis and neurodegenerative disease. Mol Neurodegener (2015) 0.89