Contribution of the respiratory network to rhythm and motor output revealed by modulation of GIRK channels, somatostatin and neurokinin-1 receptors.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27599866)

Published in Sci Rep on September 07, 2016

Authors

Gaspard Montandon1, Hattie Liu1, Richard L Horner1

Author Affiliations

1: Departments of Medicine and Physiology, University of Toronto, Toronto, Canada.

Articles cited by this

Pre-Bötzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science (1991) 8.26

Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex. Science (1999) 3.58

Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci (2001) 3.05

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci (2010) 2.69

Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nat Neurosci (2008) 2.69

5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science (2003) 2.28

Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression. Anesthesiology (2010) 2.25

Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation. Neuron (2003) 2.12

Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons. Nat Neurosci (2005) 1.88

Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A (1997) 1.88

A group of glutamatergic interneurons expressing high levels of both neurokinin-1 receptors and somatostatin identifies the region of the pre-Bötzinger complex. J Comp Neurol (2003) 1.85

Neuroanatomical characteristics of the human pre-Bötzinger complex and its involvement in neurodegenerative brainstem diseases. Brain (2010) 1.75

Developmental origin of preBötzinger complex respiratory neurons. J Neurosci (2010) 1.60

Functional imaging, spatial reconstruction, and biophysical analysis of a respiratory motor circuit isolated in vitro. J Neurosci (2008) 1.48

Projections of preBötzinger complex neurons in adult rats. J Comp Neurol (2010) 1.30

Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability. Trends Neurosci (2004) 1.30

PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depression. J Neurosci (2011) 1.25

Spinal opioid analgesia: how critical is the regulation of substance P signaling? J Neurosci (1999) 1.10

Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice. Elife (2014) 1.05

ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci (2013) 1.04

Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol (2012) 1.00

Cumulative lesioning of respiratory interneurons disrupts and precludes motor rhythms in vitro. Proc Natl Acad Sci U S A (2012) 0.98

Drug design at peptide receptors: somatostatin receptor ligands. J Mol Neurosci (2002) 0.93

CrossTalk proposal: The preBotzinger complex is essential for the respiratory depression following systemic administration of opioid analgesics. J Physiol (2014) 0.93

Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen Pharmacol (1998) 0.89

Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons. Proc Natl Acad Sci U S A (2002) 0.88

Dbx1 precursor cells are a source of inspiratory XII premotoneurons. Elife (2015) 0.85

Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors. Eur J Neurosci (2014) 0.85

Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology (2000) 0.84

State-dependent contribution of the hyperpolarization-activated Na+/K+ and persistent Na+ currents to respiratory rhythmogenesis in vivo. J Neurosci (2013) 0.83

Synaptic relationship between somatostatin- and neurokinin-1 receptor-immunoreactive neurons in the pre-Bötzinger complex of rats. J Neurochem (2012) 0.82

Neurokinin receptor modulation of respiratory activity in the rabbit. Eur J Neurosci (2008) 0.82

Antagonistic effects of somatostatin and substance P on respiratory regulation in the rat ventrolateral medulla oblongata. Brain Res (1991) 0.82

Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea. J Physiol (2006) 0.81

G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids. Anesthesiology (2016) 0.80

Local application of somatostatin in the rat ventrolateral brain medulla induces apnea. J Appl Physiol (1985) (1990) 0.79