Lupus Skin Is Primed for IL-6 Inflammatory Responses through a Keratinocyte-Mediated Autocrine Type I Interferon Loop.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27646883)

Published in J Invest Dermatol on September 16, 2016

Authors

Jasmine N Stannard1, Tamra J Reed2, Emily Myers3, Lori Lowe4, Mrinal K Sarkar5, Xianying Xing5, Johann E Gudjonsson5, J Michelle Kahlenberg6

Author Affiliations

1: Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA; Division of Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
2: Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
3: Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.
4: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Department of Pathology, University of Michigan, Ann Arbor, Michigan USA.
5: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
6: Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: mkahlenb@med.umich.edu.

Articles cited by this

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A (2003) 11.65

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med (1990) 2.62

Sifalimumab, a human anti-interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study. Arthritis Rheum (2013) 2.06

Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol (2010) 2.05

Expression and function of Toll-like receptors 2 and 4 in human keratinocytes. Int Immunol (2003) 1.99

Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol (2007) 1.88

Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum (2010) 1.86

Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. J Immunol (2011) 1.85

Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. J Rheumatol (2009) 1.84

Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum (2006) 1.83

Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet (2013) 1.78

Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients. J Autoimmun (2013) 1.65

Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus. J Pathol (2005) 1.62

Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic Lupus erythematosus. Arthritis Rheumatol (2014) 1.61

Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils. J Autoimmun (2015) 1.54

Natural type I interferon-producing cells as a link between innate and adaptive immunity. Hum Immunol (2002) 1.46

Interferon-kappa, a novel type I interferon expressed in human keratinocytes. J Biol Chem (2001) 1.45

Ultraviolet light induces increased circulating interleukin-6 in humans. J Invest Dermatol (1990) 1.42

Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice. Arthritis Rheum (2007) 1.37

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol (2008) 1.33

TLR2 and TLR4 in autoimmune diseases: a comprehensive review. Clin Rev Allergy Immunol (2014) 1.25

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci U S A (2009) 1.20

High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression. J Virol (2011) 1.16

Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA. Br J Dermatol (2005) 1.10

The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol (2010) 1.07

Expression of MxA protein in inflammatory dermatoses. J Histochem Cytochem (1995) 1.05

Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study. Ann Rheum Dis (2016) 1.04

Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice. J Immunol (2008) 1.02

Impact of UVB radiation on the epidermal cytokine network. Photochem Photobiol (1996) 0.99

Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus. Cytometry B Clin Cytom (2009) 0.94

Phototesting in lupus erythematosus: a 15-year experience. J Am Acad Dermatol (2001) 0.93

High mobility group box1 (HMGB1) in relation to cutaneous inflammation in systemic lupus erythematosus (SLE). Lupus (2013) 0.92

Apoptosis in the pathogenesis of cutaneous lupus erythematosus. Am J Dermatopathol (1998) 0.89

Surface expression and genotypes of Toll-like receptors 2 and 4 in patients with juvenile idiopathic arthritis and systemic lupus erythematosus. Pediatr Rheumatol Online J (2013) 0.88

Photosensitivity, apoptosis, and cytokines in the pathogenesis of lupus erythematosus: a critical review. Clin Rev Allergy Immunol (2014) 0.87

Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients. Ann Rheum Dis (2008) 0.86

Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus. Arthritis Rheum (2013) 0.86

The influence of antimalarial treatment on IL-1beta, IL-6 and TNF-alpha mRNA expression on UVB-irradiated skin in systemic lupus erythematosus. Br J Dermatol (2008) 0.82

Successful use of interleukin 6 antagonist tocilizumab in a patient with refractory cutaneous lupus and urticarial vasculitis. J Clin Rheumatol (2012) 0.82

Interleukin-6 deficiency corrects nephritis, lymphocyte abnormalities, and secondary Sjögren's syndrome features in lupus-prone Sle1.Yaa mice. Arthritis Rheumatol (2014) 0.82

Cutaneous lupus erythematosus: molecular and cellular basis of clinical findings. Curr Dir Autoimmun (2008) 0.82

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Treatment With Sirukumab (CNTO 136) in Patients With Active Lupus Nephritis. Arthritis Rheumatol (2016) 0.81

The influence of ultraviolet light on immunological cytotoxicity in the skin. Photochem Photobiol (1997) 0.81

The role of cytokines in the pathogenesis of cutaneous lupus erythematosus. Cytokine (2015) 0.80

Characterization of clinical photosensitivity in cutaneous lupus erythematosus. J Am Acad Dermatol (2013) 0.79

Elimination of Granulocytic Myeloid-Derived Suppressor Cells in Lupus-Prone Mice Linked to Reactive Oxygen Species-Dependent Extracellular Trap Formation. Arthritis Rheumatol (2016) 0.78

Articles by these authors

Induction of alternative proinflammatory cytokines accounts for sustained psoriasiform skin inflammation in IL-17C+IL-6KO mice. J Invest Dermatol (2016) 1.39

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms. J Invest Dermatol (2014) 1.36

Cross-Disease Transcriptomics: Unique IL-17A Signaling in Psoriasis Lesions and an Autoimmune PBMC Signature. J Invest Dermatol (2016) 0.87

Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture. J Invest Dermatol (2014) 0.80

22 again: IL-22 as a risk gene and important mediator in psoriasis. J Invest Dermatol (2014) 0.78

CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice. J Clin Invest (2017) 0.76

CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis? J Invest Dermatol (2015) 0.76

Psoriasis and the MAITing game: a role for IL-17A+ invariant TCR CD8+ T cells in psoriasis? J Invest Dermatol (2014) 0.75

IL-17 Responses Are the Dominant Inflammatory Signal Linking Inverse, Erythrodermic, and Chronic Plaque Psoriasis. J Invest Dermatol (2016) 0.75

Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? J Invest Dermatol (2016) 0.75

The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal. J Invest Dermatol (2016) 0.75

A gene network regulated by the transcription factor VGLL3 as a promoter of sex-biased autoimmune diseases. Nat Immunol (2016) 0.75

The Molecular Revolution in Cutaneous Biology: The Era of Global Transcriptional Analysis. J Invest Dermatol (2017) 0.75

Mouse Models of Psoriasis: A Comprehensive Review. J Invest Dermatol (2021) 0.75

Endogenous glucocorticoid deficiency in psoriasis promotes inflammation and abnormal differentiation. J Invest Dermatol (2017) 0.75