Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives.

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Published in Clin Pharmacol on September 21, 2016

Authors

Béla Z Schmidt1, Jérémy B Haaf2, Teresinha Leal2, Sabrina Noel2

Author Affiliations

1: Stem Cell Biology and Embryology, Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven.
2: Louvain Center for Toxicology and Applied Pharmacology, Université Catholique de Louvain, Brussels, Belgium.

Associated clinical trials:

Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients | NCT02190604

Exploratory Study to Evaluate QR-010 in Subjects With Cystic Fibrosis ΔF508 CFTR Mutation | NCT02564354

Dose Escalation Study of QR-010 in Homozygous ΔF508 Cystic Fibrosis Patients | NCT02532764

Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis Patients | NCT02170025

Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation (SNO-6) | NCT02589236

Study of Cavosonstat (N91115) in CF Patients Who Are Heterozygous for F508del-CFTR and a Gating Mutation and Being Treated With Ivacaftor (SNO-7) | NCT02724527

Study Assessing PTI-428 Safety, Tolerability, and Pharmacokinetics in Subjects With Cystic Fibrosis | NCT02718495

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