Immunoglobulin Fc Heterodimer Platform Technology: From Design to Applications in Therapeutic Antibodies and Proteins.

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Published in Front Immunol on October 06, 2016

Authors

Ji-Hee Ha1, Jung-Eun Kim1, Yong-Sung Kim2

Author Affiliations

1: Department of Molecular Science and Technology, Ajou University , Suwon , Korea.
2: Department of Molecular Science and Technology, Ajou University, Suwon, Korea; Department of Applied Chemistry and Biological Engineering, College of Engineering, Ajou University, Suwon, Korea.

Associated clinical trials:

A Study of Vanucizumab (RO5520985) Alone or in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors | NCT01688206

A Study of RO6895882 in Patients With Advanced and/or Metastatic Solid Tumors | NCT02004106

A Study of RO6958688 in Patients With Locally Advanced and/or Metastatic Solid Tumors | NCT02324257

AVENUE: A Proof-of-Concept Study of RG7716 in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD) | NCT02484690

A Study of Intravenous RO6895882 and MPDL3280A Combination in Patients With Locally Advanced and/or Metastatic Solid Tumors | NCT02350673

A Study of LY3164530 in Participants With Cancer | NCT02221882

A Phase III Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A Patients With Inhibitors (HAVEN 1) | NCT02622321

PH 1 Study to Evaluate Safety and Tolerability of XmAb14045 in Patients With CD123-expressing Hematologic Malignancies | NCT02730312

A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 in Participants With Advanced and/or Metastatic Solid Tumors | NCT02627274

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