Published in Sci Rep on October 21, 2016
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods (1983) 114.35
The new global map of human brucellosis. Lancet Infect Dis (2006) 12.83
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (1984) 10.83
Brucellosis. N Engl J Med (2005) 9.97
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu Rev Biochem (1990) 5.02
Selective inhibition of formation of deoxyribonucleic acid in Escherichia coli by mitomycin C. Nature (1959) 3.97
Overview of PDEs and their regulation. Circ Res (2007) 3.42
mini-Tn7 insertion in bacteria with single attTn7 sites: example Pseudomonas aeruginosa. Nat Protoc (2006) 3.19
Inhibition of fatty acid synthesis by the antibiotic cerulenin. Specific inactivation of beta-ketoacyl-acyl carrier protein synthetase. Biochim Biophys Acta (1973) 3.10
Global phenotypic characterization of bacteria. FEMS Microbiol Rev (2008) 2.97
Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med (2007) 2.58
A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication. J Bacteriol (2000) 2.56
Monensin and FCCP inhibit the intracellular transport of alphavirus membrane glycoproteins. J Cell Biol (1980) 2.50
Identification of genes required for chronic persistence of Brucella abortus in mice. Infect Immun (2000) 2.31
Global burden of human brucellosis: a systematic review of disease frequency. PLoS Negl Trop Dis (2012) 2.13
Pharmacology of protein kinase inhibitors. Annu Rev Pharmacol Toxicol (1992) 2.08
In vitro Brucella suis infection prevents the programmed cell death of human monocytic cells. Infect Immun (2000) 1.97
A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore. Proc Natl Acad Sci U S A (2009) 1.82
Abl tyrosine kinases are required for infection by Shigella flexneri. EMBO J (2003) 1.59
Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity (2012) 1.55
Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett (1993) 1.55
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation. Cancer Biol Ther (2004) 1.50
Pseudomonas aeruginosa invasion and cytotoxicity are independent events, both of which involve protein tyrosine kinase activity. Infect Immun (1998) 1.49
Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages. Infect Immun (1998) 1.48
Scaffold composition and biological relevance of screening libraries. Nat Chem Biol (2007) 1.45
Fatty acid biosynthesis as a target for novel antibacterials. Curr Opin Investig Drugs (2004) 1.33
Alkali metal cation release and respiratory inhibition induced by nigericin in rat liver mitochondria. Proc Natl Acad Sci U S A (1966) 1.28
GTPases of the Rho subfamily are required for Brucella abortus internalization in nonprofessional phagocytes: direct activation of Cdc42. J Biol Chem (2001) 1.27
Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl Acad Sci U S A (1993) 1.23
In vivo and in vitro effects of the mitochondrial uncoupler FCCP on microtubules. EMBO J (1982) 1.20
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila. PLoS Pathog (2009) 1.19
Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol Sci (1991) 1.18
Manipulation of kinase signaling by bacterial pathogens. J Cell Biol (2011) 1.14
Inhibition of de novo fatty acid synthesis by the antibiotic cerulenin in Bacillus subtilis: effects on citrate-Mg2+ transport and synthesis of macromolecules. Antimicrob Agents Chemother (1975) 1.11
Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery. Proc Natl Acad Sci U S A (2009) 1.10
Application of a homogenous membrane potential assay to assess mitochondrial function. Physiol Genomics (2012) 1.03
Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. J Immunol (2013) 1.00
Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication. J Virol (2011) 0.99
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol (1986) 0.99
Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice. Infect Immun (2002) 0.99
Role of Ca2+ and calmodulin in ehrlichial infection in macrophages. Infect Immun (1995) 0.99
Mitomycin-C induces the apoptosis of human Tenon's capsule fibroblast by activation of c-Jun N-terminal kinase 1 and caspase-3 protease. Invest Ophthalmol Vis Sci (2005) 0.99
Antifolate agents: a patent review (2006 - 2010). Expert Opin Ther Pat (2011) 0.95
Effects of multiple conformers per compound upon 3-D similarity search and bioassay data analysis. J Cheminform (2012) 0.95
Cell viability assessment: toward content-rich platforms. Expert Opin Drug Discov (2010) 0.94
Mechanism of action of CM-55, a synthetic analogue of the antilipogenic antibiotic cerulenin. Antimicrob Agents Chemother (1974) 0.94
Aligning antimicrobial drug discovery with complex and redundant host-pathogen interactions. Cell Host Microbe (2009) 0.93
Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase. J Pharmacol Exp Ther (2011) 0.92
Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Vet Microbiol (2006) 0.89
Generation of superoxide anions and hydrogen peroxide from beta-lapachone in bacteria. Antimicrob Agents Chemother (1978) 0.89
Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens. MBio (2014) 0.88
Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses. Antimicrob Agents Chemother (2011) 0.85
Uncouplers of oxidative phosphorylation. Pharmacol Ther (1980) 0.84
5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. Infect Immun (2015) 0.84
The prenylation inhibitor manumycin A reduces the viability of Anaplasma phagocytophilum. J Med Microbiol (2011) 0.83
RGS2-mediated intracellular Ca2+ level plays a key role in the intracellular replication of Brucella abortus within phagocytes. J Infect Dis (2011) 0.80
β-Lapachone activity in synergy with conventional antimicrobials against methicillin resistant Staphylococcus aureus strains. Phytomedicine (2013) 0.79
Metal acquisition and virulence in Brucella. Anim Health Res Rev (2012) 0.79
A20 promotes Brucella intracellular growth via inhibition of macrophage cell death and activation. Vet Microbiol (2014) 0.79
The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria. Mol Biochem Parasitol (1999) 0.79
Coordinated zinc homeostasis is essential for the wild-type virulence of Brucella abortus. J Bacteriol (2015) 0.78