Published in Am J Physiol Heart Circ Physiol on October 21, 2016
STUDIES ON EXPERIMENTAL HYPERTENSION : I. THE PRODUCTION OF PERSISTENT ELEVATION OF SYSTOLIC BLOOD PRESSURE BY MEANS OF RENAL ISCHEMIA. J Exp Med (1934) 14.72
Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. J Physiol (1937) 8.25
The sympathetic control of blood pressure. Nat Rev Neurosci (2006) 6.44
Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release. Br J Pharmacol (1977) 6.01
Reflex cardiovascular and respiratory responses originating in exercising muscle. J Physiol (1972) 5.50
The reflex nature of the pressor response to muscular exercise. J Physiol (1971) 3.74
Coronary physiology. Physiol Rev (1983) 3.33
Pathogenesis of hypertension. Ann Intern Med (2003) 3.18
Regulation of coronary blood flow during exercise. Physiol Rev (2008) 2.84
Sympathetic nervous system overactivity and its role in the development of cardiovascular disease. Physiol Rev (2010) 2.74
Observations in man on a pulse-accelerating reflex from the voluntary muscles of the legs. J Physiol (1938) 2.34
Effect of metabolic products of muscular contraction on discharge of group III and IV afferents. J Appl Physiol (1985) (1988) 2.33
Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans. J Clin Invest (1988) 2.32
Effect of exercise on cardiac output, left coronary flow and myocardial metabolism in the unanesthetized dog. Circ Res (1965) 2.08
Exaggerated sympathetic and pressor responses to handgrip exercise in older hypertensive humans: role of the muscle metaboreflex. Am J Physiol Heart Circ Physiol (2010) 1.90
Responses of group IV afferent units from skeletal muscle to stretch, contraction and chemical stimulation. Exp Brain Res (1978) 1.84
Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry. J Am Coll Cardiol (2004) 1.77
Muscle metaboreflex-induced coronary vasoconstriction functionally limits increases in ventricular contractility. J Appl Physiol (1985) (2010) 1.63
Regional vascular resistance vs. conductance: which index for baroreflex responses? Am J Physiol (1991) 1.57
Effects of changes in preload, afterload and inotropic state on ejection and isovolumic phase measures of contractility in the conscious dog. Am J Cardiol (1975) 1.45
alpha-adrenergic coronary vasoconstriction and myocardial ischemia in humans. Circulation (2000) 1.44
Role played by purinergic receptors on muscle afferents in evoking the exercise pressor reflex. J Appl Physiol (1985) (2002) 1.41
Role of the sympathetic nervous system in human hypertension. J Hypertens (1998) 1.41
On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans. J Physiol (2011) 1.39
Regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic alpha- and beta-receptors. Circ Res (1977) 1.37
EXPERIMENTS ON NERVOUS FACTORS CONTROLLING RESPIRATION AND CIRCULATION DURING EXERCISE EMPLOYING BLOCKING OF THE BLOOD FLOW. Acta Physiol Scand (1964) 1.31
Cardiovascular responses to graded reductions in hindlimb perfusion in exercising dogs. Am J Physiol (1983) 1.31
Autonomic mechanisms of muscle metaboreflex control of heart rate. J Appl Physiol (1985) (1993) 1.26
Exercise blood pressure predicts cardiovascular mortality in middle-aged men. Hypertension (1994) 1.25
ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents. Am J Physiol Heart Circ Physiol (2002) 1.22
Exercise pressor reflex function is altered in spontaneously hypertensive rats. J Physiol (2006) 1.21
Muscle chemoreflex-induced increases in right atrial pressure. Am J Physiol (1998) 1.20
Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise. J Appl Physiol (1985) (1998) 1.19
Muscle metaboreflex-induced increases in stroke volume. Med Sci Sports Exerc (2003) 1.18
Muscle sympathetic nerve activity in renovascular hypertension and primary aldosteronism. Hypertension (1991) 1.18
Peripheral adrenergic receptors in hypertension. Hypertension (1990) 1.13
Evidence for functional alterations in the skeletal muscle mechanoreflex and metaboreflex in hypertensive rats. Am J Physiol Heart Circ Physiol (2008) 1.12
Muscle metaboreflex improves O2 delivery to ischemic active skeletal muscle. Am J Physiol (1999) 1.10
Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise. Circ Res (1988) 1.10
Exercise blood pressure predicts mortality from myocardial infarction. Hypertension (1996) 1.09
Interstitial pH, K(+), lactate, and phosphate determined with MSNA during exercise in humans. Am J Physiol Regul Integr Comp Physiol (2000) 1.08
Severe exercise alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol (2001) 1.08
Is the muscle metaboreflex important in control of blood flow to ischemic active skeletal muscle in dogs? Am J Physiol (1995) 1.08
Heart failure alters the strength and mechanisms of the muscle metaboreflex. Am J Physiol Heart Circ Physiol (2000) 1.07
Increased sympathetic nerve activity in renovascular hypertension. Circulation (1999) 1.06
Does inadequate oxygen delivery trigger pressor response to muscle hypoperfusion during exercise? Am J Physiol (1987) 1.05
Muscle metaboreflex control of ventricular contractility during dynamic exercise. Am J Physiol Heart Circ Physiol (2005) 1.05
Abnormal muscle metaboreflex control of sympathetic activity in never-treated hypertensive subjects. Am J Hypertens (2006) 1.05
Control of coronary blood flow during exercise. Exp Biol Med (Maywood) (2002) 1.04
Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol (1994) 1.03
Heart rate increase and maximal heart rate during exercise as predictors of cardiovascular mortality: a 16-year follow-up study of 1960 healthy men. Coron Artery Dis (1995) 1.03
Muscle metaboreflex increases ventricular performance in conscious dogs. Am J Physiol (1998) 1.01
Feedforward sympathetic coronary vasodilation in exercising dogs. J Appl Physiol (1985) (2000) 1.00
Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans. Am J Physiol (1992) 1.00
Enhanced metaboreflex sensitivity in hypertensive humans. Eur J Appl Physiol (2008) 0.99
The paradox of adrenergic coronary vasoconstriction. Circulation (1987) 0.98
Mechanisms of fatigue-induced activation of group IV muscle afferents: the roles played by lactic acid and inflammatory mediators. Neurosci Lett (1998) 0.98
Skeletal muscle reflex-mediated changes in sympathetic nerve activity are abnormal in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2011) 0.98
WISE 2005: stroke volume changes contribute to the pressor response during ischemic handgrip exercise in women. J Appl Physiol (1985) (2007) 0.98
Muscle metaboreflex control of the circulation during exercise. Acta Physiol (Oxf) (2010) 0.97
Systemic arterial blood pressure during exercise in patients with atherosclerosis obliterans of the lower limbs. Circulation (1972) 0.96
Modulation of cardiac output alters the mechanisms of the muscle metaboreflex pressor response. Am J Physiol Heart Circ Physiol (2009) 0.96
Determinants of exercise blood pressure response in normotensive and hypertensive women: role of cardiorespiratory fitness. J Cardiopulm Rehabil (2002) 0.94
Role of heart rate and stroke volume during muscle metaboreflex-induced cardiac output increase: differences between activation during and after exercise. J Physiol Sci (2011) 0.94
Impact of alpha-adrenergic coronary vasoconstriction on the transmural myocardial blood flow distribution during humoral and neuronal adrenergic activation. Circ Res (1993) 0.94
Baroreflex attenuates pressor response to graded muscle ischemia in exercising dogs. Am J Physiol (1990) 0.94
Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP/dt(max) complementary or redundant? Am J Physiol Heart Circ Physiol (2012) 0.93
Effects of preload, afterload and inotropy on dynamics of ischemic segmental wall motion. J Am Coll Cardiol (1997) 0.93
Supine and exercise systolic blood pressure predict cardiovascular death in middle-aged men. J Hypertens (2001) 0.92
Quantitative analysis of feedforward sympathetic coronary vasodilation in exercising dogs. J Appl Physiol (1985) (2000) 0.92
Attenuated arterial baroreflex buffering of muscle metaboreflex in heart failure. Am J Physiol Heart Circ Physiol (2005) 0.92
Role of cardiac output versus peripheral vasoconstriction in mediating muscle metaboreflex pressor responses: dynamic exercise versus postexercise muscle ischemia. Am J Physiol Regul Integr Comp Physiol (2013) 0.91
Alpha 1- and alpha 2-adrenoceptor-mediated vasoconstriction of large and small canine coronary arteries in vivo. J Cardiovasc Pharmacol (1984) 0.90
Muscle metaboreflex control of coronary blood flow. Am J Physiol Heart Circ Physiol (2002) 0.89
Dynamic exercise in man as influenced by experimental restriction of blood flow in the working muscles. Acta Physiol Scand (1987) 0.89
Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion. Am J Physiol Heart Circ Physiol (2011) 0.89
Heart rate and arterial pressure variability in the experimental renovascular hypertension model in rats. Auton Neurosci (2008) 0.89
Muscle metaboreflex-induced increases in cardiac sympathetic activity vasoconstrict the coronary vasculature. J Appl Physiol (1985) (2007) 0.88
Exaggerated exercise pressor reflex in adults with moderately elevated systolic blood pressure: role of purinergic receptors. Am J Physiol Heart Circ Physiol (2013) 0.88
Antagonism of the TRPv1 receptor partially corrects muscle metaboreflex overactivity in spontaneously hypertensive rats. J Physiol (2011) 0.88
Beneficial Effect of a Long-Term Antihypertensive Therapy on Blood Pressure Response to Isometric Handgrip Exercise in Patients with Essential Hypertension. Am J Ther (1995) 0.87
Prejunctional modulation of noradrenaline release by alpha 2-adrenoceptors: physiological and pharmacological implications in the cardiovascular system. J Cardiovasc Pharmacol (1982) 0.87
Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency. Am J Physiol Heart Circ Physiol (2013) 0.87
Evaluation of muscle metaboreflex function through graded reduction in forearm blood flow during rhythmic handgrip exercise in humans. Am J Physiol Heart Circ Physiol (2011) 0.87
Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise. Circ Res (1988) 0.86
Elevated sympathetic nerve activity in patients with accelerated essential hypertension. J Clin Invest (1993) 0.86
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension. Hypertension (1992) 0.86
Does gender influence the strength and mechanisms of the muscle metaboreflex during dynamic exercise in dogs? Am J Physiol (1999) 0.85
Contribution of pH, diprotonated phosphate and potassium for the reflex increase in blood pressure during handgrip. Acta Physiol Scand (1998) 0.85
Muscle metaboreflex activation during dynamic exercise evokes epinephrine release resulting in β2-mediated vasodilation. Am J Physiol Heart Circ Physiol (2014) 0.85
Relation between left ventricular oxygen consumption and pressure-volume area in conscious dogs. Circulation (1994) 0.85
Early depression of the baroreceptor sensitivity during onset of hypertension. Hypertension (1992) 0.84
The paradox of α-adrenergic coronary vasoconstriction revisited. J Mol Cell Cardiol (2011) 0.84
alpha-Adrenoceptor attenuation of the coronary vascular response to severe exercise in the conscious dog. Circ Res (1979) 0.84
Alpha 1-adrenergic constriction limits coronary flow and cardiac function in running dogs. Am J Physiol (1986) 0.84
Mechanism of decreased baroreceptor activity in chronic hypertensive rabbits. Role of endogenous prostanoids. J Clin Invest (1990) 0.83
Augmentation of the exercise pressor reflex in prehypertension: roles of the muscle metaboreflex and mechanoreflex. Appl Physiol Nutr Metab (2013) 0.83
Impaired central mediation of the arterial baroreflex in chronic renal hypertension. Am J Physiol (1984) 0.83
Cardiovascular responses to muscle ischemia in humans. Circ Res (1981) 0.82
Muscle metaboreflex activation during dynamic exercise evokes epinephrine release resulting in β2-mediated vasodilation. Am J Physiol Heart Circ Physiol (2014) 0.85
Muscle metaboreflex activation during dynamic exercise vasoconstricts ischemic active skeletal muscle. Am J Physiol Heart Circ Physiol (2015) 0.77
Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension. Am J Physiol Regul Integr Comp Physiol (2015) 0.75
Interaction between the muscle metaboreflex and the arterial baroreflex in control of arterial pressure and skeletal muscle blood flow. Am J Physiol Heart Circ Physiol (2016) 0.75
Role of endothelial nitric oxide in control of peripheral vascular conductance during muscle metaboreflex activation. Am J Physiol Regul Integr Comp Physiol (2017) 0.75