Published in PLoS One on October 27, 2016
Molecular mechanisms of human hypertension. Cell (2001) 11.17
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol (2006) 6.38
Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71
Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature (2013) 5.44
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature (2013) 4.74
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature (2013) 4.57
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A (1996) 4.11
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med (2009) 4.07
Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology (2007) 3.96
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev (2006) 3.63
The inflammasome: an integrated view. Immunol Rev (2011) 3.52
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome. J Immunol (2011) 3.05
The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation (2011) 2.89
Para-inflammation in the aging retina. Prog Retin Eye Res (2009) 2.71
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components. Nat Med (2012) 2.49
The association of cardiovascular disease with the long-term incidence of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology (2003) 2.49
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation. Immunity (2013) 2.45
NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment. Proc Natl Acad Sci U S A (2004) 2.42
Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A (2012) 2.19
Plasma sodium: ignored and underestimated. Hypertension (2004) 2.15
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (2014) 1.77
Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci (2003) 1.69
NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.58
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD). Immunol Lett (2012) 1.46
Systemic hypertension and age-related maculopathy in the Framingham Study. Arch Ophthalmol (1986) 1.45
Hypertonic saline enhances cellular immune function. Circ Shock (1994) 1.41
Purinergic signaling in special senses. Trends Neurosci (2009) 1.35
P2 receptors and extracellular ATP: a novel homeostatic pathway in inflammation. Front Biosci (Schol Ed) (2011) 1.31
A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome. PLoS One (2013) 1.22
Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol (2010) 1.22
Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation). Mediators Inflamm (2014) 1.20
Sodium overload and water influx activate the NALP3 inflammasome. J Biol Chem (2010) 1.20
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration. Cell Rep (2013) 1.18
TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci (2013) 1.11
(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J Med Chem (2007) 1.10
Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. J Immunol (2008) 1.06
Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents. J Clin Invest (2009) 1.05
Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun (2015) 0.99
Is age-related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment. J Intern Med (2014) 0.95
NFAT5 in cellular adaptation to hypertonic stress - regulations and functional significance. J Mol Signal (2013) 0.94
Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β. Cell Mol Life Sci (2010) 0.92
Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study. Transl Res (2014) 0.91
Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Mol Vis (2015) 0.86
Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells. Biochim Biophys Acta (2014) 0.83
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage. J Mol Med (Berl) (2015) 0.83
Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18. Invest Ophthalmol Vis Sci (2015) 0.81
Effects of Inflammasome Activation on Secretion of Inflammatory Cytokines and Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci (2015) 0.79
Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One (2016) 0.78
Müller glial cells in retinal disease. Ophthalmologica (2011) 1.31
Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Mol Vis (2015) 0.86
Purinergic signaling in retinal degeneration and regeneration. Neuropharmacology (2015) 0.84
Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One (2016) 0.78
Intake of dietary salt and drinking water: Implications for the development of age-related macular degeneration. Mol Vis (2016) 0.76
Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis (2015) 0.75
Osmotic regulation of NFAT5 expression in RPE cells: The involvement of purinergic receptor signaling. Mol Vis (2017) 0.75
Expression and signaling of NGF in the healthy and injured retina. Cytokine Growth Factor Rev (2016) 0.75