Kinetics, prognostic and predictive values of ESR1 circulating mutations in metastatic breast cancer patients progressing on aromatase inhibitor.

PubWeight™: 0.92‹?›

🔗 View Article (PMID 27801670)

Published in Oncotarget on October 27, 2016

Authors

Florian Clatot1,2,3, Anne Perdrix3,4, Laetitia Augusto1, Ludivine Beaussire3,5, Julien Delacour3,5, Céline Calbrix4, David Sefrioui3,5,6, Pierre-Julien Viailly2, Michael Bubenheim7, Cristian Moldovan1, Cristina Alexandru1, Isabelle Tennevet1, Olivier Rigal1, Cécile Guillemet1, Marianne Leheurteur1, Sophie Gouérant1, Camille Petrau1,3, Jean-Christophe Théry1,5, Jean-Michel Picquenot1,2,4, Corinne Veyret1, Thierry Frébourg5, Fabrice Jardin2, Nasrin Sarafan-Vasseur3,5, Frédéric Di Fiore1,3,5,6

Author Affiliations

1: Department of Medical Oncology, Henri Becquerel Centre, Rouen, France.
2: INSERM U918, Henri Becquerel Centre, Rouen, France.
3: EquIpe de Recherche en Oncologie, Rouen, France.
4: Department of Biopathology, Henri Becquerel Centre, Rouen, France.
5: INSERM U1079, Faculty of Medecine, Rouen, France.
6: Department of Gastroenterology, Rouen University Hospital, Rouen, France.
7: Department of Biostatistics, Rouen University Hospital, Rouen, France.

Articles cited by this

Comprehensive molecular portraits of human breast tumours. Nature (2012) 47.39

Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med (2011) 13.74

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet (2013) 4.03

Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet (2013) 3.96

Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol (2001) 3.92

Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep (2013) 3.85

Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods (2013) 3.63

Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer. Sci Transl Med (2015) 3.33

Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2†. Ann Oncol (2014) 1.95

Prevalence of ESR1 Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer: A Secondary Analysis of the BOLERO-2 Clinical Trial. JAMA Oncol (2016) 1.83

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer. Cancer Res (1997) 1.82

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor. Nature (2014) 1.61

Analysis of ESR1 mutation in circulating tumor DNA demonstrates evolution during therapy for metastatic breast cancer. Sci Transl Med (2015) 1.52

Fulvestrant plus palbociclib versus fulvestrant plus placebo for treatment of hormone-receptor-positive, HER2-negative metastatic breast cancer that progressed on previous endocrine therapy (PALOMA-3): final analysis of the multicentre, double-blind, phase 3 randomised controlled trial. Lancet Oncol (2016) 1.41

Sensitive Detection of Mono- and Polyclonal ESR1 Mutations in Primary Tumors, Metastatic Lesions, and Cell-Free DNA of Breast Cancer Patients. Clin Cancer Res (2015) 1.29

ESR1 mutations—a mechanism for acquired endocrine resistance in breast cancer. Nat Rev Clin Oncol (2015) 1.22

Noninvasive detection of activating estrogen receptor 1 (ESR1) mutations in estrogen receptor-positive metastatic breast cancer. Clin Chem (2015) 1.19

Plasma ESR1 Mutations and the Treatment of Estrogen Receptor-Positive Advanced Breast Cancer. J Clin Oncol (2016) 1.18

ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients. Clin Cancer Res (2015) 1.18

The search for ESR1 mutations in breast cancer. Nat Genet (2013) 1.13

Short report: Monitoring ESR1 mutations by circulating tumor DNA in aromatase inhibitor resistant metastatic breast cancer. Int J Cancer (2015) 1.02

Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant. Nat Commun (2016) 0.99

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models. Cancer Res (2016) 0.88

Estrogen receptor mutations in breast cancer--new focus on an old target. Clin Cancer Res (2014) 0.87

Mutation Analysis of Cell-Free DNA and Single Circulating Tumor Cells in Metastatic Breast Cancer Patients with High Circulating Tumor Cell Counts. Clin Cancer Res (2016) 0.84

Clinical significance of monitoring ESR1 mutations in circulating cell-free DNA in estrogen receptor positive breast cancer patients. Oncotarget (2016) 0.83

(1) 0.77