Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27832197)

Published in PLoS One on November 10, 2016

Authors

Mercedes Piedad de León-Bautista1, Maria Del Carmen Cardenas-Aguayo2, Diana Casique-Aguirre1, Manuel Almaraz-Salinas3, Sara Parraguirre-Martinez4, Angelica Olivo-Diaz5, María Del Rocío Thompson-Bonilla6, Miguel Vargas1

Author Affiliations

1: Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, col. San Pedro Zacatenco, C.P. 07360, Mexico City, Mexico.
2: Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Col. Copilco Universidad, Delegación Coyoacán, C.P. 04510, Mexico City, Mexico.
3: Facultad de Bioquímica, Instituto Tecnológico de Milpa Alta, Independencia Sur 36, San Salvador Cuauhtenco, Milpa Alta, 12300, Mexico City, Mexico.
4: Departamento de Anatomía Patológica, Hospital General Doctor Manuel Gea González, Av. Calzada de Tlalpan 4800, Tlalpan, Sección XVI, 14080, Mexico City, Mexico.
5: Departamento de Biología Molecular e Histocompatibilidad, Hospital Doctor Manuel Gea González, Av. Calzada de Tlalpan 4800, Tlalpan, Sección XVI, 14080, Mexico City, Mexico.
6: Investigación Biomédica y Traslacional, Laboratorio de Medicina Genómica, Hospital 1° de Octubre, ISSSTE, Av. Instituto Politécnico Nacional No. 1669, Colonia: Magdalena de las Salinas, Delegación: Gustavo A Madero, 07760, Mexico City, Mexico.

Articles cited by this

Cancer statistics, 2013. CA Cancer J Clin (2013) 84.72

Rho GTPases in cell biology. Nature (2002) 22.81

RHO-GTPases and cancer. Nat Rev Cancer (2002) 8.03

Rho GTPases in cancer cell biology. FEBS Lett (2008) 4.47

GDIs: central regulatory molecules in Rho GTPase activation. Trends Cell Biol (2005) 4.13

A practical guide to evaluating colocalization in biological microscopy. Am J Physiol Cell Physiol (2011) 3.74

Rho GTPases are over-expressed in human tumors. Int J Cancer (1999) 3.70

Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89

Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer (1975) 2.78

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature (2003) 2.72

Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer (2002) 2.38

Six classes of nuclear localization signals specific to different binding grooves of importin alpha. J Biol Chem (2008) 2.26

RhoGDI2 is an invasion and metastasis suppressor gene in human cancer. Cancer Res (2002) 2.01

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol Cell Biol (2001) 1.99

Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene (1999) 1.91

The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J Biol Chem (1992) 1.84

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat Struct Biol (2000) 1.77

Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res (2003) 1.76

Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. Curr Biol (1999) 1.71

Characterization of a new primary human pancreatic tumor line. Cancer Invest (1986) 1.67

The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Mol Cell Biol (1991) 1.54

Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. Mol Biol Cell (2001) 1.53

RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development. Genes Dev (2003) 1.48

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta (2004) 1.45

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. Proc Natl Acad Sci U S A (1993) 1.44

Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer. Proteomics (2002) 1.31

Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. Mol Cancer Ther (2005) 1.18

Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein. Biochem Biophys Res Commun (1989) 1.18

D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness. Cancer Res (2006) 1.18

Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function. Proc Natl Acad Sci U S A (2009) 1.17

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase. J Cell Sci (2004) 1.16

Suppression of rho B expression in invasive carcinoma from head and neck cancer patients. Clin Cancer Res (2002) 1.15

RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. Proc Natl Acad Sci U S A (1997) 1.10

RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility. J Biol Chem (2012) 1.09

Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. Mol Cancer Ther (2009) 1.09

Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling. J Biol Chem (2009) 1.09

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI. J Mol Biol (2001) 1.08

Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. Structure (1997) 1.06

TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation. Cancer Res (2009) 1.02

Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. Oncogene (2003) 1.01

RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. Traffic (2002) 0.99

Biphasic expression of RhoGDI2 in the progression of breast cancer and its negative relation with lymph node metastasis. Oncol Rep (2007) 0.98

EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation. Oncogene (2004) 0.97

RhoB regulates cell migration through altered focal adhesion dynamics. Open Biol (2012) 0.93

Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. Genes Chromosomes Cancer (1993) 0.91

Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation. Blood (1996) 0.90

Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis. Cell Death Differ (1999) 0.89

Downregulation of Rho-GDI gamma promotes differentiation of neural stem cells. Mol Cell Biochem (2008) 0.83

RhoB loss induces Rac1-dependent mesenchymal cell invasion in lung cells through PP2A inhibition. Oncogene (2015) 0.83

Loss of RhoGDI is a novel independent prognostic factor in hepatocellular carcinoma. Int J Clin Exp Pathol (2013) 0.82

RhoGDI2 confers resistance to 5-fluorouracil in human gastric cancer cells. Oncol Lett (2012) 0.80

Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. Int J Mol Med (2014) 0.79

Subcellular fractionation enhances proteome coverage of pancreatic duct cells. Biochim Biophys Acta (2013) 0.78

Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3. Genomics (1998) 0.77

RhoGDI3 and RhoG: Vesicular trafficking and interactions with the Sec3 Exocyst subunit. Small GTPases (2010) 0.76

Reduced expression of Rho guanine nucleotide dissociation inhibitor-alpha modulates the cytotoxic effect of busulfan in HEK293 cells. Anticancer Drugs (2007) 0.76