Immune checkpoint blockade in small cell lung cancer: is there a light at the end of the tunnel?

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🔗 View Article (PMID 27843619)

Published in ESMO Open on August 05, 2016

Authors

Luca Paglialunga1, Zena Salih2, Biagio Ricciuti1, Raffaele Califano3

Author Affiliations

1: Department of Medical Oncology , Santa Maria della Misericordia Hospital , Perugia , Italy.
2: Department of Medical Oncology , The Christie NHS Foundation Trust , Manchester , UK.
3: Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK; Department of Medical Oncology, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.

Associated clinical trials:

Trial in Extensive-Disease Small Cell Lung Cancer (ED-SCLC) Subjects Comparing Ipilimumab Plus Etoposide and Platinum Therapy to Etoposide and Platinum Therapy Alone | NCT01450761

The Addition of Ipilimumab to Carboplatin and Etoposide Chemotherapy for Extensive Stage Small Cell Lung Cancer (ICE) | NCT01331525

Pembrolizumab in Treating Patients With Extensive Stage Small Cell Lung Cancer After Completion of Combination Chemotherapy | NCT02359019

Small Cell Lung Carcinoma Trial With Nivolumab and IpiliMUmab in LImited Disease (STIMULI) | NCT02046733

Effectiveness Study of Nivolumab Compared to Chemotherapy in Patients With Relapsed Small-cell Lung Cancer (CheckMate331) | NCT02481830

Safety and Efficacy Study of Ulocuplumab and Nivolumab in Subjects With Solid Tumors (CXCessoR4) | NCT02472977

A Study of Nivolumab, or Nivolumab in Combination With Ipilimumab, or Placebo in Patients With Extensive-Stage Disease Small Cell Lung Cancer (ED-SCLC) After Completion of Platinum-based Chemotherapy (CheckMate 451) | NCT02538666

Durvalumab With or Without Tremelimumab in Advanced Incurable Solid Malignancies Receiving Standard Chemotherapy Regimens | NCT02537418

Pembrolizumab in Untreated Extensive SCLC (REACTION) | NCT02580994

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