Published in Int J Mol Sci on November 14, 2016
Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers (1983) 99.69
GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation. J Chem Theory Comput (2008) 34.90
GROMACS: fast, flexible, and free. J Comput Chem (2005) 27.22
Canonical dynamics: Equilibrium phase-space distributions. Phys Rev A Gen Phys (1985) 26.82
Knowledge-based protein secondary structure assignment. Proteins (1995) 14.08
P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation. J Chem Theory Comput (2008) 4.56
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature (1994) 3.95
STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins. Nucleic Acids Res (2004) 3.71
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Physiol Rev (2011) 2.70
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes. Diabetes (1999) 2.41
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia (2010) 2.21
Islet amyloid formed from diabetes-associated peptide may be pathogenic in type-2 diabetes. Lancet (1987) 2.15
Islet amyloid and type 2 diabetes mellitus. N Engl J Med (2000) 2.07
Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution. Proc Natl Acad Sci U S A (2009) 2.02
Conformational transitions of islet amyloid polypeptide (IAPP) in amyloid formation in vitro. J Mol Biol (1999) 1.89
Direct detection of transient alpha-helical states in islet amyloid polypeptide. Protein Sci (2006) 1.74
Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology. Biochim Biophys Acta (2001) 1.63
A temperature predictor for parallel tempering simulations. Phys Chem Chem Phys (2008) 1.63
Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide. J Mol Biol (2009) 1.53
Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry (2008) 1.51
Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle. Proc Natl Acad Sci U S A (1988) 1.47
Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. Protein Sci (2009) 1.46
Human islet amyloid polypeptide monomers form ordered beta-hairpins: a possible direct amyloidogenic precursor. J Am Chem Soc (2009) 1.46
A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides. Protein Eng Des Sel (2009) 1.38
Dynamic alpha-helix structure of micelle-bound human amylin. J Biol Chem (2009) 1.36
Preparation of synthetic human islet amyloid polypeptide (IAPP) in a stable conformation to enable study of conversion to amyloid-like fibrils. FEBS Lett (2000) 1.25
The amyloid formation mechanism in human IAPP: dimers have β-strand monomer-monomer interfaces. J Am Chem Soc (2011) 1.22
Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet. Proc Natl Acad Sci U S A (2013) 1.20
Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment. Biochim Biophys Acta (2011) 1.20
Stable and metastable states of human amylin in solution. Biophys J (2010) 1.08
Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus. Proc Natl Acad Sci U S A (1989) 1.04
The molecular basis of distinct aggregation pathways of islet amyloid polypeptide. J Biol Chem (2010) 1.01
Solution state structures of human pancreatic amylin and pramlintide. Protein Eng Des Sel (2009) 1.00
Dynamics of an intrinsically disordered protein reveal metastable conformations that potentially seed aggregation. J Am Chem Soc (2013) 0.96
Mechanistic studies of peptide self-assembly: transient α-helices to stable β-sheets. J Am Chem Soc (2010) 0.92
Comparative molecular dynamics study of human islet amyloid polypeptide (IAPP) and rat IAPP oligomers. Biochemistry (2013) 0.90
Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation. Biophys J (2014) 0.89
Amyloidogenicity and cytotoxicity of recombinant mature human islet amyloid polypeptide (rhIAPP). J Biol Chem (2004) 0.87
Molecular simulations indicate marked differences in the structure of amylin mutants, correlated with known aggregation propensity. J Phys Chem B (2013) 0.86
Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides. PLoS Comput Biol (2013) 0.86
Comparing the structural properties of human and rat islet amyloid polypeptide by MD computer simulations. Biophys Chem (2010) 0.84
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions. FASEB J (2015) 0.83
Effect of proline mutations on the monomer conformations of amylin. Biophys J (2013) 0.83
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology. J Diabetes Res (2015) 0.83
Characterizing the assembly behaviors of human amylin: a perspective derived from C-terminal variants. Chem Commun (Camb) (2012) 0.81
An Account of Amyloid Oligomers: Facts and Figures Obtained from Experiments and Simulations. Chembiochem (2016) 0.77
Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia. Oncotarget (2016) 0.77
Insights into the Conformational Ensemble of Human Islet Amyloid Polypeptide from Molecular Simulations. Curr Pharm Des (2016) 0.76