Published in J Virol on July 01, 1989
The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1. EMBO J (1990) 2.03
Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. J Virol (1991) 1.80
Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells. Proc Natl Acad Sci U S A (1990) 1.52
Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy. J Virol (1995) 1.50
In vivo genomic variability of human T-cell leukemia virus type I depends more upon geography than upon pathologies. J Virol (1991) 1.46
Human T-cell lymphotropic virus type 1 Tax mediates enhanced transcription in CD4+ T lymphocytes. J Virol (1996) 1.22
Role of protein kinase A in tax transactivation of the human T-cell leukemia virus type I long terminal repeat. J Virol (1990) 0.94
Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway. J Virol (1996) 0.92
T helper cell activation and human retroviral pathogenesis. Microbiol Rev (1996) 0.88
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Biochem Biophys Res Commun (2010) 0.86
Phorbol esters modulate the phosphorylation of human T-cell leukemia virus type I Tax. J Virol (1993) 0.83
Activation of human T-cell leukemia virus type 1 tax gene expression in chronically infected T cells. J Virol (1998) 0.83
Multistep regulation of enhancer activity of the 21-base-pair element of human T-cell leukemia virus type I. J Virol (1992) 0.81
Triple synergism of human T-lymphotropic virus type 1-encoded tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T-cell leukemia cells. Mol Cell Biol (1997) 0.80
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res (1981) 35.39
DNAse footprinting: a simple method for the detection of protein-DNA binding specificity. Nucleic Acids Res (1978) 30.43
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature (1984) 24.45
A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system. Nucleic Acids Res (1981) 24.41
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell (1983) 17.87
I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (1988) 16.40
Studies and perspectives of protein kinase C. Science (1986) 14.73
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell (1987) 14.62
Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A (1983) 14.09
Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci U S A (1986) 10.41
Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature (1987) 8.93
Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature (1988) 7.99
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus. J Virol (1984) 7.80
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. Nature (1988) 7.35
The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell (1988) 6.75
Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I. Science (1987) 5.22
HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science (1988) 4.77
Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell (1987) 4.76
Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J (1986) 4.58
Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex. Cell (1988) 4.15
Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science (1988) 4.01
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science (1987) 4.01
Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature (1987) 3.94
fos-associated cellular p39 is related to nuclear transcription factor AP-1. Cell (1988) 3.82
Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription. Proc Natl Acad Sci U S A (1986) 3.60
Human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc Natl Acad Sci U S A (1987) 3.47
Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. Science (1984) 3.20
Human adult T-cell leukemia virus: molecular cloning of the provirus DNA and the unique terminal structure. Proc Natl Acad Sci U S A (1982) 3.19
A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1. Genes Dev (1988) 3.13
Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancer. Proc Natl Acad Sci U S A (1986) 3.12
Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. J Virol (1987) 3.03
HIV/HTLV gene nomenclature. Nature (1988) 2.72
Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence. J Virol (1988) 2.67
Tumor promoter, TPA, enhances replication of HTLV-III/LAV. Virology (1986) 2.51
Transcription control by oncogenes. Cell (1985) 2.45
Phorbol ester enhances human immunodeficiency virus-promoted gene expression and acts on a repeated 10-base-pair functional enhancer element. Mol Cell Biol (1987) 2.42
Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci U S A (1988) 2.40
Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature (1986) 2.22
Regulation of HIV and HTLV gene expression. Genes Dev (1988) 2.19
Binding of host-cell factors to DNA sequences in the long terminal repeat of human T-cell leukemia virus type I: implications for viral gene expression. Proc Natl Acad Sci U S A (1988) 2.12
Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP. J Biol Chem (1987) 1.96
Involvement of common and cell type-specific pathways in c-fos gene control: stable induction of cAMP in macrophages. Cell (1987) 1.83
Expression of the complete human T-cell leukemia virus type I pX coding sequence as a functional protein in Escherichia coli. Proc Natl Acad Sci U S A (1986) 1.41
Human T-cell leukemia virus types I and II exhibit different DNase I protection patterns. J Virol (1988) 1.35
Abundant synthesis of functional human T-cell leukemia virus type I p40x protein in eucaryotic cells by using a baculovirus expression vector. J Virol (1987) 1.31
Transcriptional activation of homologous viral long terminal repeats by the human immunodeficiency virus type 1 or the human T-cell leukemia virus type I tat proteins occurs in the absence of de novo protein synthesis. Proc Natl Acad Sci U S A (1988) 1.29
Long terminal repeat structure of an American isolate of type I human T-cell leukemia virus. Virology (1984) 1.19
Transient expression of foreign genes in lymphoid cells is enhanced by phorbol ester. Mol Cell Biol (1987) 1.12
Phorbol ester and Epstein-Barr virus dependent transformation of normal primary human skin epithelial cells. Nature (1987) 0.97
Molecular mechanisms of phorbol ester, thyrotropin-releasing hormone, and growth factor stimulation of prolactin gene transcription. J Biol Chem (1985) 0.84
Tat trans-activates the human immunodeficiency virus through a nascent RNA target. Cell (1989) 6.28
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR. Science (1991) 4.66
A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent. Proc Natl Acad Sci U S A (1994) 4.43
Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell (1998) 4.21
Multiple tandemly repeated binding sites for cellular nuclear factor 1 that surround the major immediate-early promoters of simian and human cytomegalovirus. J Virol (1987) 3.68
lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells. Cell (1987) 3.33
HIV-1 tat transcriptional activity is regulated by acetylation. EMBO J (1999) 3.10
Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat. J Virol (1987) 3.03
Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat. J Virol (1992) 2.93
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry (1998) 2.87
TAR-independent activation of the HIV-1 LTR: evidence that tat requires specific regions of the promoter. Cell (1990) 2.82
Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci U S A (1996) 2.33
Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat. J Biol Chem (1998) 2.26
Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1. Proc Natl Acad Sci U S A (2000) 2.23
Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR. EMBO J (1997) 2.16
Identification of cellular proteins that bind to the human immunodeficiency virus type 1 trans-activation-responsive TAR element RNA. Proc Natl Acad Sci U S A (1989) 2.14
Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. J Biol Chem (1997) 2.01
Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J Biol Chem (1997) 1.99
Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen. Mol Cell Biol (1993) 1.98
Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction. J Biol Chem (1989) 1.97
The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in Golgi and plasma membranes. Virology (1989) 1.93
Localization of the coding region for an Epstein-Barr virus early antigen and inducible expression of this 60-kilodalton nuclear protein in transfected fibroblast cell lines. J Virol (1985) 1.85
Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. J Biol Chem (1999) 1.82
Human immunodeficiency viruses regulated by alternative trans-activators: genetic evidence for a novel non-transcriptional function of Tat in virion infectivity. EMBO J (1994) 1.78
Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem (1999) 1.77
Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins. J Virol (1992) 1.77
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA. J Virol (1994) 1.70
Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression. J Virol (1992) 1.68
Efficient trans-activation by the HIV-2 Tat protein requires a duplicated TAR RNA structure. Nucleic Acids Res (1990) 1.67
Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol (1998) 1.66
Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA. Arch Biochem Biophys (1999) 1.66
Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS (1997) 1.65
Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1. J Biol Chem (1996) 1.63
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (1999) 1.59
HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR. Virology (1995) 1.56
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat. J Virol (1998) 1.53
Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. EMBO J (2000) 1.49
Characterization of cytomegalovirus immediate-early genes. I. Nonpermissive rodent cells overproduce the IE94K protein form CMV (Colburn). Virology (1982) 1.49
The palindromic series I repeats in the simian cytomegalovirus major immediate-early promoter behave as both strong basal enhancers and cyclic AMP response elements. J Virol (1990) 1.45
Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains. Nucleic Acids Res (1991) 1.44
A cycloheximide-enhanced protein in cytomegalovirus-infected cells. Virology (1980) 1.43
Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles. J Virol (1996) 1.41
HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs. Virology (1996) 1.35
Abundant synthesis of functional human T-cell leukemia virus type I p40x protein in eucaryotic cells by using a baculovirus expression vector. J Virol (1987) 1.31
A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes. J Biol Chem (1998) 1.28
Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc Natl Acad Sci U S A (1999) 1.25
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. J Biol Chem (1997) 1.24
The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein. J Virol (1995) 1.24
A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem (1998) 1.24
Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-kappaB activation. Oncogene (2001) 1.23
Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a. J Virol (1997) 1.22
Induction of micronuclei by HTLV-I Tax: a cellular assay for function. Virology (1993) 1.20
Abundant constitutive expression of the immediate-early 94K protein from cytomegalovirus (Colburn) in a DNA-transfected mouse cell line. Mol Cell Biol (1984) 1.20
The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells. EMBO J (1994) 1.14
Definition of a minimal activation domain in human T-cell leukemia virus type I Tax. J Virol (1995) 1.10
Gene therapy for human immunodeficiency virus infection: genetic antiviral strategies and targets for intervention. Hum Gene Ther (1994) 1.09
CREB/ATF-dependent repression of cyclin a by human T-cell leukemia virus type 1 Tax protein. J Virol (2001) 1.08
Identification, cloning, and characterization of an immune activation gene. Proc Natl Acad Sci U S A (1988) 1.07
HTLV-I Tax self-association in optimal trans-activation function. Nucleic Acids Res (1997) 1.07
Increased spacing between Sp1 and TATAA renders human immunodeficiency virus type 1 replication defective: implication for Tat function. J Virol (1993) 1.06
Novel induction by herpes simplex virus of hybrid interferon gene transcripts driven by the strong cytomegalovirus IE94 promoter. J Virol (1987) 1.05
Aromatic polyamidines inhibiting the Tat-induced HIV-1 transcription recognize structured TAR-RNA. Antisense Nucleic Acid Drug Dev (2001) 1.05
Isolation of full-length cDNA and chromosomal localization of human NF-kappaB modulator NEMO to Xq28. J Biomed Sci (1999) 1.05
Recombinant human immunodeficiency virus type 1 genomes with tat unconstrained by overlapping reading frames reveal residues in Tat important for replication in tissue culture. J Virol (1996) 1.04
Characterization of human and mouse peroxiredoxin IV: evidence for inhibition by Prx-IV of epidermal growth factor- and p53-induced reactive oxygen species. Antioxid Redox Signal (2000) 1.03
Promoter activity of Tat at steps subsequent to TATA-binding protein recruitment. Mol Cell Biol (1997) 1.02
Constitutively dead, conditionally live HIV-1 genomes. Ex vivo implications for a live virus vaccine. J Biol Chem (2001) 1.02
HTLV-I Tax is a zinc-binding protein: role of zinc in Tax structure and function. Virology (1992) 1.02
Clastogenic effect of the human T-cell leukemia virus type I Tax oncoprotein correlates with unstabilized DNA breaks. J Biol Chem (2000) 1.02
Tat as a transcriptional activator and a potential therapeutic target for HIV-1. Adv Pharmacol (2000) 1.01
Modeling HIV transfer between dendritic cells and T cells: importance of HIV phenotype, dendritic cell-T cell contact and T-cell activation. AIDS (2000) 1.00
A baculovirus vector can express intron-containing genes. J Virol (1987) 0.99
Transfection with the isolated herpes simplex virus thymidine kinase genes. I. Minimal size of the active fragments from HSV-1 and HSV-2. J Gen Virol (1982) 0.98
HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms. Arch Biochem Biophys (2000) 0.97
Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors. AIDS Res Hum Retroviruses (2000) 0.97
A cytomegalovirus DNA sequence containing tracts of tandemly repeated CA dinucleotides hybridizes to highly repetitive dispersed elements in mammalian cell genomes. Mol Cell Biol (1983) 0.96
Characterization of TRBP1 and TRBP2. Stable stem-loop structure at the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in its processed pseudogene. J Biomed Sci (2000) 0.96
Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation. Biochem Biophys Res Commun (1998) 0.96
HTLV-I Tax and cell cycle progression. Prog Cell Cycle Res (2000) 0.95
Conditional reduction of human immunodeficiency virus type 1 replication by a gain-of-herpes simplex virus 1 thymidine kinase function. Proc Natl Acad Sci U S A (1996) 0.94
Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents. Proc Natl Acad Sci U S A (1994) 0.94
Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53. J Virol (2001) 0.94
Glutamine-rich domains activate transcription in yeast Saccharomyces cerevisiae. J Biol Chem (1998) 0.93
Molecular biology of human immunodeficiency virus type 1. J Microbiol Immunol Infect (2000) 0.93
Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun (1999) 0.92
Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development. J Biol Chem (1999) 0.92
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter. FASEB J (2000) 0.92
The basic RNA-binding domain of HIV-2 Tat contributes to preferential trans-activation of a TAR2-containing LTR. Nucleic Acids Res (1992) 0.91
Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway. J Biol Chem (1996) 0.89
Human herpesvirus 8 infection occurs following adolescence in the United States. J Infect Dis (1997) 0.89
An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop. J Mol Biol (1998) 0.89
The mechanistic role of enhancer elements in eukaryotic transcription. Bioessays (1988) 0.88
Sequential steps in Tat trans-activation of HIV-1 mediated through cellular DNA, RNA, and protein binding factors. Gene Expr (1996) 0.88
Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice. Blood Cancer J (2013) 0.88
Long-range jumping of incompletely extended polymerase chain fragments generates unexpected products. Biotechniques (1994) 0.88
Geographical differences in human herpesvirus 8 seroepidemiology: a survey of 1,201 individuals in Asia. J Med Virol (2000) 0.88
Pleiotropic effects of HTLV type 1 Tax protein on cellular metabolism: mitotic checkpoint abrogation and NF-kappaB activation. AIDS Res Hum Retroviruses (2000) 0.87