High prevalence of infectious adeno-associated virus (AAV) in human peripheral blood mononuclear cells indicative of T lymphocytes as sites of AAV persistence.

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Published in J Virol on December 07, 2016

Authors

Daniela Hüser1, Dina Khalid1, Timo Lutter1, Eva-Maria Hammer1, Stefan Weger1, Melanie Heßler1, Ulrich Kalus2, Yvonne Tauchmann2, Karin Hensel-Wiegel3, Dirk Lassner4, Regine Heilbronn5

Author Affiliations

1: Institute of Virology, Campus Benjamin Franklin, Charité Medical School, Berlin, Germany.
2: Institute of Transfusion Medicine, Charité Medical School, Berlin, Germany.
3: Labor Berlin-Charité Vivantes GmbH, Berlin, Germany.
4: Institut Kardiale Diagnostik und Therapie (IKDT), Berlin, Germany.
5: Institute of Virology, Campus Benjamin Franklin, Charité Medical School, Berlin, Germany regine.heilbronn@charite.de.

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Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell (1997) 3.99

Herpes simplex virus types 1 and 2 completely help adenovirus-associated virus replication. J Virol (1981) 3.72

Adenoviruses in the immunocompromised host. Clin Microbiol Rev (1992) 3.56

Serologic evidence for human infection with adenovirus-associated viruses. J Natl Cancer Inst (1968) 3.44

Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors. Hum Gene Ther (2010) 3.37

Cloning and characterization of adeno-associated virus type 5. J Virol (1999) 3.36

Physical assay and growth cycle studies of a defective adeno-satellite virus. J Virol (1967) 3.15

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High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation (2005) 3.06

In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). J Exp Med (1988) 2.81

Characterization of the DNA of a defective human parvovirus isolated from a genital site. Virology (1984) 2.49

Analysis of proteins, helper dependence, and seroepidemiology of a new human parvovirus. Virology (1984) 2.13

The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification. J Virol (1990) 2.00

Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate model. J Virol (1999) 1.95

Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV). J Med Virol (1999) 1.93

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Complete DNA sequence of the rat cytomegalovirus genome. J Virol (2000) 1.85

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A seroepidemiologic study of adenovirus-associated virus infection in infants and children. Am J Epidemiol (1971) 1.57

Modification of some biological properties of HeLa cells containing adeno-associated virus DNA integrated into chromosome 17. J Virol (1992) 1.45

Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. Nature (1991) 1.41

Human cytomegalovirus completely helps adeno-associated virus replication. Virology (1985) 1.39

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Antibodies to adeno-associated satellite virus and herpes simplex in sera from cancer patients and normal adults. Am J Obstet Gynecol (1976) 1.32

Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia. Gene Ther (2011) 1.24

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Detection of adeno-associated virus DNA in human genital tissue and in material from spontaneous abortion. J Med Virol (1994) 1.14

Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome. PLoS Pathog (2010) 1.12

Infectious molecular clones of adeno-associated virus isolated directly from human tissues. J Virol (2008) 1.11

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Detection of adeno-associated virus type 2 in human peripheral blood cells. J Gen Virol (1992) 0.98

Evidence for infection of the human embryo with adeno-associated virus in pregnancy. Hum Reprod (1999) 0.97

Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7. New Microbiol (2007) 0.95

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