Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27936029)

Published in PLoS One on December 09, 2016

Authors

Kewei Wang1, Minhua Wang1, Maureen Gannon2, AiXuan Holterman1

Author Affiliations

1: Department of Surgery/Pediatric Surgery, U of Illinois College of Medicine, Peoria, IL, United States of America.
2: Departments of Medicine/Molecular Physiology/Biophysics, Vanderbilt University Medical Center, Nashville, TN, United States of America.

Articles cited by this

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74

Transcription factors in liver development, differentiation, and regeneration. Hepatology (2003) 3.06

The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development (2002) 2.89

Sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol (2009) 2.45

The IGF-I receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta (1997) 2.38

Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol (2000) 2.11

Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev (2005) 2.02

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology (2004) 2.02

Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis. J Hepatol (2002) 1.99

Getting TRAIL back on track for cancer therapy. Cell Death Differ (2014) 1.86

A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells. Oncogene (2005) 1.66

The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev Biol (1997) 1.52

Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology (2015) 1.49

Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation. J Biol Chem (2003) 1.39

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. J Biol Chem (2002) 1.36

Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol (2011) 1.36

Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone. Mol Endocrinol (2000) 1.26

Hepatoprotective effects of insulin-like growth factor I in rats with carbon tetrachloride-induced cirrhosis. Gastroenterology (1997) 1.25

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev (2009) 1.23

The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Dev Biol (2007) 1.20

Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology (2010) 1.17

Insulin-like growth factor-I and the liver. Liver Int (2011) 1.13

Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone. Proc Natl Acad Sci U S A (1997) 1.11

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc Natl Acad Sci U S A (2015) 1.10

OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. J Biol Chem (1999) 1.09

Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver. J Biol Chem (2000) 1.08

Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration. Gastroenterology (2006) 1.07

IAP family of cell death and signaling regulators. Methods Enzymol (2014) 1.03

Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology (2010) 1.00

Inhibitors of apoptotic proteins: new targets for anticancer therapy. Chem Biol Drug Des (2013) 1.00

Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6. Diabetologia (2002) 0.99

Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in β-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP). J Biol Chem (2012) 0.98

Activation of the IGF1 system characterizes cholangiocyte survival during progression of primary biliary cirrhosis. J Histochem Cytochem (2006) 0.97

Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction. Hepatology (2002) 0.93

Transcriptional activation by growth hormone of HNF-6-regulated hepatic genes, a potential mechanism for improved liver repair during biliary injury in mice. Am J Physiol Gastrointest Liver Physiol (2008) 0.93

Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology (2012) 0.93

Insulin-like growth factor-1 isoforms in rat hepatocytes and cholangiocytes and their involvement in protection against cholestatic injury. Lab Invest (2008) 0.92

Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen. Hepatology (2002) 0.92

Altered liver gene expression in CCl4-cirrhotic rats is partially normalized by insulin-like growth factor-I. Int J Biochem Cell Biol (2002) 0.91

Bile salts regulate proliferation and apoptosis of liver cells by modulating the IGF1 system. Dig Liver Dis (2007) 0.89

In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction. Hepatology (2004) 0.88

Degradation of cIAPs contributes to hepatocyte lipoapoptosis. Am J Physiol Gastrointest Liver Physiol (2013) 0.87

Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large bile ducts. Am J Physiol Gastrointest Liver Physiol (2010) 0.86

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development (2015) 0.86

Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity. PLoS One (2014) 0.82

Foxa2 may modulate hepatic apoptosis through the cIAP1 pathway. Cell Signal (2012) 0.82

Alterations in growth hormone receptor abundance regulate growth hormone signaling in murine obstructive cholestasis. Am J Physiol Gastrointest Liver Physiol (2004) 0.79

IAPs: Modular regulators of cell signalling. Semin Cell Dev Biol (2014) 0.79

Hepatitis: After HCV cure, HBV cure? Nat Rev Gastroenterol Hepatol (2015) 0.79

New therapies for hepatic fibrosis. Clin Res Hepatol Gastroenterol (2015) 0.78

Gene transfer of IGF1 attenuates hepatocellular apoptosis after bile duct ligation. J Surg Res (2009) 0.78

cIAP1 attenuates shear stress-induced hBMSC apoptosis for tissue-engineered blood vessels through the inhibition of the mitochondrial apoptosis pathway. Life Sci (2015) 0.76

Cellular inhibitor of apoptosis protein 1 (cIAP1) stability contributes to YM155 resistance in human gastric cancer cells. J Biol Chem (2015) 0.76