Published in Ann Transl Med on November 01, 2016
Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data. Lancet Respir Med (2014) 9.74
When are randomised trials unnecessary? Picking signal from noise. BMJ (2007) 6.77
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Selecting the right tool for the job. Am J Bioeth (2015) 6.11
Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58
Will Ebola change the game? Ten essential reforms before the next pandemic. The report of the Harvard-LSHTM Independent Panel on the Global Response to Ebola. Lancet (2015) 5.58
Reducing waste from incomplete or unusable reports of biomedical research. Lancet (2014) 5.37
A case of severe Ebola virus infection complicated by gram-negative septicemia. N Engl J Med (2014) 4.57
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med (2006) 3.72
Case reports in an evidence-based world. J R Soc Med (1999) 3.55
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
The first use of penicillin in the United States. Ann Intern Med (2008) 3.32
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med (2005) 3.26
Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature (2005) 3.09
Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection. Cell (2011) 3.03
Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea. PLoS Med (2016) 2.88
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature (2012) 2.53
Pandemic preparedness and response--lessons from the H1N1 influenza of 2009. N Engl J Med (2014) 2.41
Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand. J Exp Med (2008) 2.30
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol (2004) 2.22
Ebola hemorrhagic fever and septic shock. J Infect Dis (2003) 2.19
Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med (2013) 2.17
What Happens When Underperforming Big Ideas in Research Become Entrenched? JAMA (2016) 2.17
Infectious diseases. Debate erupts on 'repurposed' drugs for Ebola. Science (2014) 2.14
Statin treatment after onset of sepsis in a murine model improves survival. Circulation (2005) 2.08
Endotoxic shock model with fluid resuscitation in Macaca mulatta. Lab Anim (2005) 2.04
Broken barriers: a new take on sepsis pathogenesis. Sci Transl Med (2011) 2.01
Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA (2016) 1.97
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One (2009) 1.93
Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study. J Infect Dis (2011) 1.91
Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med (2012) 1.81
The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature (2013) 1.78
Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance. Science (2014) 1.77
Population-based study of statins, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors on pneumonia-related outcomes. Clin Infect Dis (2012) 1.75
Healthy user and related biases in observational studies of preventive interventions: a primer for physicians. J Gen Intern Med (2011) 1.74
Macrophage-expressed IFN-β contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia. PLoS Pathog (2013) 1.74
Why have clinical trials in sepsis failed? Trends Mol Med (2014) 1.71
Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients. Circulation (2005) 1.71
ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Am J Physiol Renal Physiol (2010) 1.69
Toward a Common Secure Future: Four Global Commissions in the Wake of Ebola. PLoS Med (2016) 1.68
A global biomedical R&D fund and mechanism for innovations of public health importance. PLoS Med (2015) 1.64
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection. Sci Transl Med (2013) 1.62
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest (2011) 1.61
The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med (2009) 1.61
Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation (2006) 1.55
Pathogenesis of influenza-induced acute respiratory distress syndrome. Lancet Infect Dis (2013) 1.55
Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study. PLoS One (2011) 1.55
Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med (2016) 1.54
Possible involvement of angiotensin-converting enzyme 2 and Mas activation in inhibitory effects of angiotensin II Type 1 receptor blockade on vascular remodeling. Hypertension (2012) 1.50
Treating Ebola patients: a 'bottom up' approach using generic statins and angiotensin receptor blockers. Int J Infect Dis (2015) 1.50
Olmesartan decreased levels of IL-1β and TNF-α, down-regulated MMP-2, MMP-9, COX-2, RANK/RANKL and up-regulated SOCs-1 in an intestinal mucositis model. PLoS One (2014) 1.49
Seasonal influenza vaccine dose distribution in 195 countries (2004-2013): Little progress in estimated global vaccination coverage. Vaccine (2015) 1.48
Open source clinical science for emerging infections. Lancet Infect Dis (2014) 1.47
Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med (2015) 1.45
Pandemic influenza: a potential role for statins in treatment and prophylaxis. Clin Infect Dis (2006) 1.44
Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence (2013) 1.42
A guide to immunometabolism for immunologists. Nat Rev Immunol (2016) 1.41
Angiotensin receptor 1 blockade reduces secretion of inflammation associated cytokines from cultured human carotid atheroma and vascular cells in association with reduced extracellular signal regulated kinase expression and activation. Atherosclerosis (2014) 1.40
Influenza H5N1 virus infection of polarized human alveolar epithelial cells and lung microvascular endothelial cells. Respir Res (2009) 1.40
Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial). Crit Care (2012) 1.39
Angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratio as indicators of potential severity of Plasmodium vivax malaria in patients with thrombocytopenia. PLoS One (2014) 1.39
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature (2016) 1.38
Ten questions about systems biology. J Physiol (2011) 1.36
Cytokine response patterns in severe pandemic 2009 H1N1 and seasonal influenza among hospitalized adults. PLoS One (2011) 1.35
Evaluating clinical trial designs for investigational treatments of Ebola virus disease. PLoS Med (2015) 1.35
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol (2008) 1.32
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest (2013) 1.32
The antioxidant defense protein heme oxygenase 1 is a novel target for statins in endothelial cells. Free Radic Biol Med (2004) 1.30
Simvastatin in the acute respiratory distress syndrome. N Engl J Med (2014) 1.29
CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28
Mitochondria and endothelial function. Circ Res (2013) 1.27
The Neglected Dimension of Global Security--A Framework for Countering Infectious-Disease Crises. N Engl J Med (2016) 1.24
Meeting the challenge of influenza pandemic preparedness in developing countries. Emerg Infect Dis (2009) 1.22
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir Med (2016) 1.22
Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway. Am J Physiol Cell Physiol (2011) 1.21
H7N9 avian influenza A virus and the perpetual challenge of potential human pandemicity. MBio (2013) 1.20
Physiological and immunologic disturbances associated with shock in a primate model of Lassa fever. J Infect Dis (1987) 1.20
ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis. Br J Pharmacol (2013) 1.19
Oxidative stress in vascular disease and its pharmacological prevention. Trends Pharmacol Sci (2013) 1.19
Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial. JAMA (2013) 1.18
Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections. J Gen Virol (2013) 1.17
Redefining the gut as the motor of critical illness. Trends Mol Med (2013) 1.15
Clinical Management of Ebola Virus Disease in the United States and Europe. N Engl J Med (2016) 1.15
Ebola: Europe-Africa research collaborations. Lancet Infect Dis (2015) 1.12
Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria. PLoS Pathog (2012) 1.11
Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1-7/Mas axis. Am J Physiol Lung Cell Mol Physiol (2011) 1.11
Influence of Statins on Influenza Vaccine Response in Elderly Individuals. J Infect Dis (2015) 1.11
Do viral infections mimic bacterial sepsis? The role of microvascular permeability: A review of mechanisms and methods. Antiviral Res (2011) 1.11
Organ- and endotheliotropism of Nipah virus infections in vivo and in vitro. Thromb Haemost (2009) 1.11
Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells. PLoS One (2012) 1.09
Endothelial barrier dysfunction in septic shock. J Intern Med (2015) 1.09
Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection. Proc Natl Acad Sci U S A (2014) 1.09
ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease. Hypertens Res (2010) 1.08
Impact of Statins on Influenza Vaccine Effectiveness Against Medically Attended Acute Respiratory Illness. J Infect Dis (2015) 1.08
Statins suppress interleukin-6-induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells. Br J Pharmacol (2010) 1.07
H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response. J Immunol (2010) 1.07
Methods to adjust for bias and confounding in critical care health services research involving observational data. J Crit Care (2006) 1.07
Causality and causal inference in epidemiology: the need for a pluralistic approach. Int J Epidemiol (2016) 1.07