Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

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Published in Cancer Cell on December 12, 2016

Authors

Shigeki Nakagawa1, Lan Wei2, Won Min Song3, Takaaki Higashi1, Sarani Ghoshal2, Rosa S Kim4, C Billie Bian4, Suguru Yamada2, Xiaochen Sun4, Anu Venkatesh4, Nicolas Goossens5, Gretchen Bain6, Gregory Y Lauwers7, Anna P Koh4, Mohamed El-Abtah4, Noor B Ahmad4, Hiroki Hoshida4, Derek J Erstad2, Ganesh Gunasekaran8, Youngmin Lee4, Ming-Lung Yu9, Wan-Long Chuang10, Chia-Yen Dai10, Masahiro Kobayashi11, Hiromitsu Kumada11, Toru Beppu12, Hideo Baba12, Milind Mahajan13, Venugopalan D Nair14, Michael Lanuti15, Augusto Villanueva4, Angelo Sangiovanni16, Massimo Iavarone16, Massimo Colombo16, Josep M Llovet17, Aravind Subramanian18, Andrew M Tager19, Scott L Friedman4, Thomas F Baumert20, Myron E Schwarz8, Raymond T Chung21, Kenneth K Tanabe2, Bin Zhang13, Bryan C Fuchs22, Yujin Hoshida23, Precision Liver Cancer Prevention Consortium

Author Affiliations

1: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
2: Division of Surgical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
3: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
4: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
5: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Division of Gastroenterology and Hepatology, Geneva University Hospital, 41205 Geneva, Switzerland.
6: PharmAkea Therapeutics, San Diego, CA 92109, USA.
7: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
8: Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
9: Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, and Faculty of Medicine, College of Medicine, and Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
10: Hepatobiliary Division, Department of Internal Medicine and Hepatitis Center, Kaohsiung Medical University Hospital, and Faculty of Medicine, College of Medicine, and Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
11: Department of Hepatology, Toranomon Hospital, Tokyo 105-0001, Japan.
12: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
13: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
14: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
15: Division of Thoracic Surgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
16: M. & A. Migliavacca Center for Liver Disease and 1st Division of Gastroenterology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, Italy.
17: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Liver Cancer Translational Research Laboratory, Barcelona Clinic Liver Cancer Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, CIBERehd, Universitat de Barcelona, Institució Catalana de Recerca i Estudis Avançats, Catalonia, 08036 Barcelona, Spain.
18: Cancer Program, Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.
19: Pulmonary and Critical Care Unit, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
20: Institut National de la Santé et de la Recherche Médicale, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Université de Strasbourg, 67081 Strasbourg, France; Institut Hospitalo-Universitaire, Pôle hépato-digestif, Nouvel Hôpital Civil, 67000 Strasbourg, France; Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
21: Liver Center, Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
22: Division of Surgical Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA. Electronic address: bfuchs@mgh.harvard.edu.
23: Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: yujin.hoshida@mssm.edu.

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