Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 28000894)

Published in Oncol Rep on December 16, 2016

Authors

Hao Jin1, Xin Jin1, Boran Cao1, Wenbo Wang1

Author Affiliations

1: Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

Articles cited by this

Inflammation and cancer. Nature (2002) 53.78

Cancer-related inflammation. Nature (2008) 34.21

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80

NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol (2005) 13.98

Molecular cloning of the interleukin-1 beta converting enzyme. Science (1992) 4.19

Inflammation and necrosis promote tumour growth. Nat Rev Immunol (2004) 3.68

Caspase-1-induced pyroptotic cell death. Immunol Rev (2011) 3.47

Berberine inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis (2006) 1.71

Caspase-1-like regulation of the proPO-system and role of ppA and caspase-1-like cleaved peptides from proPO in innate immunity. PLoS Pathog (2014) 1.50

Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials. Cancer Prev Res (Phila) (2009) 1.31

p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Mol Carcinog (2009) 1.21

Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma. Bone (2005) 1.11

Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat Rev Immunol (2015) 1.10

Environment, inflammation, and cancer. Curr Opin Genet Dev (2010) 1.06

Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res (2008) 1.04

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog (2014) 1.02

Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis. PLoS One (2014) 0.90

Effect of berberine on proliferation, biosynthesis of macromolecules, cell cycle and induction of intercalation with DNA, dsDNA damage and apoptosis in Ehrlich ascites carcinoma cells. J Pharm Pharmacol (2006) 0.86

Interleukins 1 and 6 as Main Mediators of Inflammation and Cancer. Biochemistry (Mosc) (2016) 0.85

Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal. Tumour Biol (2015) 0.84

Dysfunction of brain pericytes in chronic neuroinflammation. J Cereb Blood Flow Metab (2015) 0.83

Increased multi-drug resistance and reduced apoptosis in osteosarcoma side population cells are crucial factors for tumor recurrence. Exp Ther Med (2016) 0.83

Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway. Drug Des Devel Ther (2015) 0.83

Berberine induces apoptosis and DNA damage in MG‑63 human osteosarcoma cells. Mol Med Rep (2014) 0.81

Tumor suppressor berberine binds VASP to inhibit cell migration in basal-like breast cancer. Oncotarget (2016) 0.80

Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery. Expert Opin Drug Discov (2013) 0.78

Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. J Med Food (2014) 0.78

Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis. Drug Des Devel Ther (2015) 0.77

Diagnostic challenges of low-grade central osteosarcoma of jaw: a literature review. J Dent (Shiraz) (2015) 0.77

Design, synthesis, and anticancer activity of novel berberine derivatives prepared via CuAAC "click" chemistry as potential anticancer agents. Drug Des Devel Ther (2014) 0.77

Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms. Toxicol Lett (2014) 0.77

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice. Environ Toxicol (2016) 0.77