Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28029431)

Published in Kidney Int on October 28, 2016

Authors

Chi-Yuan Hsu1, Dawei Xie2, Sushrut S Waikar3, Joseph V Bonventre3, Xiaoming Zhang2, Venkata Sabbisetti3, Theodore E Mifflin2, Josef Coresh4, Clarissa J Diamantidis5, Jiang He6, Claudia M Lora7, Edgar R Miller4, Robert G Nelson8, Akinlolu O Ojo9, Mahboob Rahman10, Jeffrey R Schelling10, Francis P Wilson11, Paul L Kimmel12, Harold I Feldman2, Ramachandran S Vasan13, Kathleen D Liu14, CRIC Study Investigators, CKD Biomarkers Consortium

Author Affiliations

1: University of California, San Francisco, San Francisco, California, USA; Kaiser Permanente Northern California, Oakland, California, USA. Electronic address: hsuchi@medicine.ucsf.edu.
2: University of Pennsylvania, Philadelphia, Pennsylvania, USA.
3: Brigham and Women's Hospital, Boston, Massachusetts, USA.
4: Johns Hopkins University, Baltimore, Maryland, USA.
5: Duke University, Durham, North Carolina, USA.
6: Tulane University, New Orleans, Louisiana, USA.
7: University of Illinois, Chicago, Illinois, USA.
8: National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.
9: University of Michigan, Ann Arbor, Michigan, USA.
10: Case Western Reserve University, Cleveland, Ohio, USA.
11: Yale University, New Haven, Connecticut, USA.
12: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
13: Boston University, Boston, Massachusetts, USA.
14: University of California, San Francisco, San Francisco, California, USA.

Articles cited by this

Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med (1996) 46.18

Validation of the Framingham coronary heart disease prediction scores: results of a multiple ethnic groups investigation. JAMA (2001) 17.91

Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60

Evaluating the yield of medical tests. JAMA (1982) 14.05

The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods. J Am Soc Nephrol (2003) 7.79

The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states. Kidney Int (2007) 6.99

Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA (2012) 6.26

The risk of acute renal failure in patients with chronic kidney disease. Kidney Int (2008) 5.87

Soluble Urokinase Receptor and Chronic Kidney Disease. N Engl J Med (2015) 4.85

A predictive model for progression of chronic kidney disease to kidney failure. JAMA (2011) 4.22

Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function. Clin J Am Soc Nephrol (2009) 4.16

Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev (2008) 3.49

Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease. Clin J Am Soc Nephrol (2009) 3.01

Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol (2012) 2.75

Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol (2012) 2.58

Tubular markers do not predict the decline in glomerular filtration rate in type 1 diabetic patients with overt nephropathy. Kidney Int (2011) 2.52

Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis (2012) 2.52

Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney Int (2013) 2.48

Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42

Biomarkers in chronic kidney disease: a review. Kidney Int (2011) 2.25

Urinary liver-type fatty acid-binding protein predicts progression to nephropathy in type 1 diabetic patients. Diabetes Care (2010) 2.06

Multiple factors influence glomerular albumin permeability in rats. J Am Soc Nephrol (2012) 1.99

CKD in Hispanics: Baseline characteristics from the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic-CRIC Studies. Am J Kidney Dis (2011) 1.88

Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol (2006) 1.85

A composite urine biomarker reflects interstitial inflammation in lupus nephritis kidney biopsies. Kidney Int (2011) 1.77

Intrarenal handling of proteins in rats using fractional micropuncture technique. Am J Physiol (1992) 1.73

Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int (1998) 1.66

Prediction of ESRD and death among people with CKD: the Chronic Renal Impairment in Birmingham (CRIB) prospective cohort study. Am J Kidney Dis (2010) 1.65

Urine stability studies for novel biomarkers of acute kidney injury. Am J Kidney Dis (2013) 1.58

Proximal Tubules Have the Capacity to Regulate Uptake of Albumin. J Am Soc Nephrol (2015) 1.53

Evaluation of the ARCHITECT urine NGAL assay: assay performance, specimen handling requirements and biological variability. Clin Biochem (2009) 1.50

Risk prediction models for patients with chronic kidney disease: a systematic review. Ann Intern Med (2013) 1.33

Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum (2012) 1.32

Association of kidney disease outcomes with risk factors for CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis (2013) 1.29

Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis (2012) 1.27

Clinical significance of urinary liver-type fatty acid-binding protein in diabetic nephropathy of type 2 diabetic patients. Diabetes Care (2011) 1.24

Effect of long-term storage of urine samples on measurement of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). Am J Kidney Dis (2013) 1.21

Induction of monocyte chemoattractant protein-1 in proximal tubule cells by urinary protein. J Am Soc Nephrol (1997) 1.20

Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis. JAMA (2016) 1.19

Predictive effects of urinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease in type 2 diabetic patients without advanced nephropathy. Diabetes Care (2012) 1.19

The proximal tubule and albuminuria: really! J Am Soc Nephrol (2014) 1.19

The value of urinary neutrophil gelatinase-associated lipocalin in risk prediction of renal decline in patients with chronic kidney disease. Kidney Int (2013) 1.09

Albumin is recycled from the primary urine by tubular transcytosis. J Am Soc Nephrol (2013) 1.05

Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides. J Am Soc Nephrol (2015) 1.05

Proteinuria and reduced glomerular filtration rate as risk factors for acute kidney injury. Curr Opin Nephrol Hypertens (2011) 1.03

Urinary neutrophil gelatinase-associated lipocalin may aid prediction of renal decline in patients with non-proteinuric Stages 3 and 4 chronic kidney disease (CKD). Nephrol Dial Transplant (2013) 1.03

Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker. Sci Transl Med (2015) 1.03

Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes. Diabetes Care (2013) 0.98

Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1). Cell Physiol Biochem (2002) 0.97

Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia (2014) 0.97

Urinary neutrophil gelatinase-associated lipocalin and progression of diabetic nephropathy in type 1 diabetic patients in a four-year follow-up study. Nephron Clin Pract (2010) 0.97

Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS). HIV Med (2013) 0.92

Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2014) 0.92

Long-term Stability of Urinary Biomarkers of Acute Kidney Injury in Children. Am J Kidney Dis (2015) 0.89

Effect of frozen storage on urinary concentration of kidney damage markers. Am J Kidney Dis (2011) 0.88

Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study. Clin J Am Soc Nephrol (2015) 0.87

Biomarkers of rapid chronic kidney disease progression in type 2 diabetes. Kidney Int (2015) 0.87

Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes. Diabetes Care (2015) 0.85

Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol (2015) 0.84

Albuminuria, wherefore art thou? J Am Soc Nephrol (2009) 0.84

A urinary proteome-based classifier for the early detection of decline in glomerular filtration. Nephrol Dial Transplant (2017) 0.84

Collection and storage requirements for urinary kidney injury molecule-1 (KIM-1) measurements in humans. Clin Chem Lab Med (2011) 0.83

How to find a prognostic biomarker for progressive diabetic nephropathy. Kidney Int (2013) 0.82

Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial. J Am Soc Nephrol (2015) 0.79

Urinary neutrophil gelatinase-associated lipocalin and clinical outcomes in chronic kidney disease patients. Clin Chem Lab Med (2015) 0.79

The authors reply. Kidney Int (2013) 0.76

Can the Urinary Peptidome Outperform Creatinine and Albumin to Predict Renal Function Decline? J Am Soc Nephrol (2015) 0.76

Plasma neutrophil gelatinase-associated lipocalin and kidney function decline and kidney disease-related clinical events in older women. Am J Nephrol (2015) 0.76

Articles by these authors

APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med (2013) 5.00

Cardiovascular outcomes in high-risk hypertensive patients stratified by baseline glomerular filtration rate. Ann Intern Med (2006) 2.81

Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2012) 2.42

Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis (2011) 2.25

Proteinuria, but Not eGFR, Predicts Stroke Risk in Chronic Kidney Disease: Chronic Renal Insufficiency Cohort Study. Stroke (2015) 2.23

Serum Fractalkine (CX3CL1) and Cardiovascular Outcomes and Diabetes: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2015) 2.03

Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC. Clin J Am Soc Nephrol (2012) 1.83

A longitudinal study of left ventricular function and structure from CKD to ESRD: the CRIC study. Clin J Am Soc Nephrol (2013) 1.72

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. Kidney Int (2014) 1.71

Association of cardiac troponin T with left ventricular structure and function in CKD. Am J Kidney Dis (2013) 1.67

Blood pressure and risk of all-cause mortality in advanced chronic kidney disease and hemodialysis: the chronic renal insufficiency cohort study. Hypertension (2014) 1.65

Retinopathy and cognitive impairment in adults with CKD. Am J Kidney Dis (2012) 1.58

Sex Differences in the Incidence of Peripheral Artery Disease in the Chronic Renal Insufficiency Cohort. Circ Cardiovasc Qual Outcomes (2016) 1.49

Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study. PLoS One (2016) 1.48

Kansas City Cardiomyopathy Questionnaire Score Is Associated With Incident Heart Failure Hospitalization in Patients With Chronic Kidney Disease Without Previously Diagnosed Heart Failure: Chronic Renal Insufficiency Cohort Study. Circ Heart Fail (2015) 1.37

Association of kidney disease outcomes with risk factors for CKD: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis (2013) 1.29

Physical performance and frailty in chronic kidney disease. Am J Nephrol (2013) 1.16

Relation of serum lipids and lipoproteins with progression of CKD: The CRIC study. Clin J Am Soc Nephrol (2014) 1.10

Influence of Nephrologist Care on Management and Outcomes in Adults with Chronic Kidney Disease. J Gen Intern Med (2015) 1.10

Novel filtration markers as predictors of all-cause and cardiovascular mortality in US adults. Am J Kidney Dis (2013) 1.05

Urinary creatinine excretion, bioelectrical impedance analysis, and clinical outcomes in patients with CKD: the CRIC study. Clin J Am Soc Nephrol (2014) 1.00

Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study. Circ Heart Fail (2014) 0.99

Filtration markers as predictors of ESRD and mortality in Southwestern American Indians with type 2 diabetes. Am J Kidney Dis (2015) 0.98

Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC). BMC Nephrol (2013) 0.94

Heart rate variability is a predictor of mortality in chronic kidney disease: a report from the CRIC Study. Am J Nephrol (2013) 0.92

Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2014) 0.92

Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study. Clin J Am Soc Nephrol (2015) 0.87

Inflammation and Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol (2016) 0.87

FGF23 modifies the relationship between vitamin D and cardiac remodeling. Circ Heart Fail (2013) 0.87

Prevalence and Prognostic Significance of Apparent Treatment Resistant Hypertension in Chronic Kidney Disease: Report From the Chronic Renal Insufficiency Cohort Study. Hypertension (2015) 0.87

Predictors and Outcomes of Health-Related Quality of Life in Adults with CKD. Clin J Am Soc Nephrol (2016) 0.86

Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study. J Am Heart Assoc (2015) 0.86

Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study. PLoS One (2015) 0.86

Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clin J Am Soc Nephrol (2015) 0.84

Change in Measured GFR Versus eGFR and CKD Outcomes. J Am Soc Nephrol (2015) 0.83

Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study). Am J Cardiol (2015) 0.81

Higher levels of cystatin C are associated with worse cognitive function in older adults with chronic kidney disease: the chronic renal insufficiency cohort cognitive study. J Am Geriatr Soc (2014) 0.81

Abrupt Decline in Kidney Function Before Initiating Hemodialysis and All-Cause Mortality: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2016) 0.80

Increasing use of vitamin D supplementation in the chronic renal insufficiency cohort study. J Ren Nutr (2014) 0.80

Serum aldosterone and death, end-stage renal disease, and cardiovascular events in blacks and whites: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Hypertension (2014) 0.80

Filtration Markers as Predictors of ESRD and Mortality: Individual Participant Data Meta-Analysis. Clin J Am Soc Nephrol (2016) 0.79

Different components of blood pressure are associated with increased risk of atherosclerotic cardiovascular disease versus heart failure in advanced chronic kidney disease. Kidney Int (2016) 0.78

Association between chronic kidney disease progression and cardiovascular disease: results from the CRIC Study. Am J Nephrol (2014) 0.78

The role of renin-angiotensin-aldosterone system genes in the progression of chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Nephrol Dial Transplant (2015) 0.77

Risks of Adverse Events in Advanced CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis (2017) 0.77

Retinopathy and the Risk of Cardiovascular Disease in Patients With Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study). Am J Cardiol (2015) 0.77

Phosphate, fibroblast growth factor 23 and retinopathy in chronic kidney disease: the Chronic Renal Insufficiency Cohort Study. Nephrol Dial Transplant (2015) 0.76

Prevalence and correlates of mitral annular calcification in adults with chronic kidney disease: Results from CRIC study. Atherosclerosis (2015) 0.75

Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease. Kidney Int (2016) 0.75

Serum Bicarbonate and Structural and Functional Cardiac Abnormalities in Chronic Kidney Disease - A Report from the Chronic Renal Insufficiency Cohort Study. Am J Nephrol (2016) 0.75

Loss of executive function after dialysis initiation in adults with chronic kidney disease. Kidney Int (2017) 0.75

Inflammatory Markers and Risk for Cognitive Decline in Chronic Kidney Disease: The CRIC Study. KI Rep (2016) 0.75

Traditional and non-traditional risk factors for incident peripheral arterial disease among patients with chronic kidney disease. Nephrol Dial Transplant (2015) 0.75

Associations of Conventional Echocardiographic Measures with Incident Heart Failure and Mortality: The Chronic Renal Insufficiency Cohort. Clin J Am Soc Nephrol (2016) 0.75

The Associations between Peripheral Artery Disease and Physical Outcome Measures in Men and Women with Chronic Kidney Disease. Ann Vasc Surg (2016) 0.75

Race/Ethnicity and Cardiovascular Outcomes in Adults With CKD: Findings From the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic CRIC Studies. Am J Kidney Dis (2016) 0.75

Fibroblast Growth Factor 23 and Anemia in the Chronic Renal Insufficiency Cohort Study. Clin J Am Soc Nephrol (2017) 0.75

Racial/Ethnic Differences in Left Ventricular Structure and Function in Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort. Am J Hypertens (2017) 0.75

Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD. Am J Kidney Dis (2020) 0.75

Cardiac and Stress Biomarkers and Chronic Kidney Disease Progression: The CRIC Study. Clin Chem (2019) 0.75

Blood pressure and the risk of chronic kidney disease progression using multistate marginal structural models in the CRIC Study. Stat Med (2017) 0.75

Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus. PLoS One (2017) 0.75

Inflammation and Arterial Stiffness in Chronic Kidney Disease: Findings From the CRIC Study. Am J Hypertens (2017) 0.75

Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD. Am J Kidney Dis (2021) 0.75

Risk Prediction Models for Atherosclerotic Cardiovascular Disease in Patients with Chronic Kidney Disease: The CRIC Study. J Am Soc Nephrol (2022) 0.75

Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality. Am J Kidney Dis (2017) 0.75

Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clin J Am Soc Nephrol (2017) 0.75