Apolipoprotein E-1Harrisburg: a new variant of apolipoprotein E dominantly associated with type III hyperlipoproteinemia.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 2804053)

Published in Biochim Biophys Acta on October 17, 1989

Authors

W A Mann1, R E Gregg, D L Sprecher, H B Brewer

Author Affiliations

1: Molecular Disease Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892.

Articles by these authors

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet (1999) 7.04

Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis (1988) 6.01

Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature (1994) 4.28

PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med (2001) 4.17

Association between myeloperoxidase levels and risk of coronary artery disease. JAMA (2001) 3.74

A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med (1995) 2.65

Advances in the gas chromatographic analysis of amino acid phenyl- and methylthiohydantoins. Anal Biochem (1972) 2.56

Human apolipoprotein B-100: cloning, analysis of liver mRNA, and assignment of the gene to chromosome 2. Proc Natl Acad Sci U S A (1985) 2.53

Cellular localization and trafficking of the human ABCA1 transporter. J Biol Chem (2001) 2.26

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science (1992) 2.24

Effect of hydroxymethylglutaryl coenzyme a reductase inhibitors on the progression of calcific aortic stenosis. Circulation (2001) 2.17

Bovine parathyroid hormone: amino acid sequence. Proc Natl Acad Sci U S A (1970) 2.08

Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet (2001) 2.08

Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients. Am J Cardiol (1984) 1.99

Abnormal in vivo metabolism of apolipoprotein E4 in humans. J Clin Invest (1986) 1.98

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science (1998) 1.93

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochem Biophys Res Commun (2001) 1.91

Association of body fat distribution and cardiovascular risk factors in children and adolescents. Circulation (1999) 1.87

Familial apolipoprotein E deficiency. J Clin Invest (1986) 1.87

The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins. Biochem Biophys Res Commun (1978) 1.75

A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy. Genomics (1990) 1.74

Quantitation of plasma apolipoproteins in the primary and secondary prevention of coronary artery disease. Ann Intern Med (1994) 1.70

Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. Proc Natl Acad Sci U S A (1972) 1.68

The plasma lipoproteins. Adv Protein Chem (1977) 1.65

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest (2001) 1.61

Overweight, fat patterning, and cardiovascular disease risk factors in black and white girls: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr (1999) 1.60

Plasma apolipoprotein A-1 absence associated with a marked reduction of high density lipoproteins and premature coronary artery disease. Arteriosclerosis (1982) 1.57

Hyperlipidemia and pancreatitis during pregnancy in two sisters with a mutation in the lipoprotein lipase gene. Ann Intern Med (1996) 1.56

Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry (1975) 1.50

Elevated plasma lipoprotein(a) in patients with the nephrotic syndrome. Ann Intern Med (1993) 1.50

High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase. Nat Med (1997) 1.48

Activation of human post heparin lipoprotein lipase by apolipoprotein H (beta 2-glycoprotein I). Biochem Biophys Res Commun (1980) 1.46

Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis. J Clin Invest (1986) 1.46

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred. Proc Natl Acad Sci U S A (1999) 1.42

Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence. Proc Natl Acad Sci U S A (1986) 1.42

Overweight, fat patterning, and cardiovascular disease risk factors in black and white boys. J Pediatr (1999) 1.41

Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease). Ann Intern Med (1980) 1.41

NIH conference. Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment. Ann Intern Med (1983) 1.36

Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains. J Biol Chem (1972) 1.36

3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation. Proc Natl Acad Sci U S A (1978) 1.34

Isolation and characterization of apolipoproteins A-I, A-II, and A-IV. Methods Enzymol (1986) 1.34

Human chylomicron apolipoprotein metabolism. Biochem Biophys Res Commun (1978) 1.34

Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux. Arterioscler Thromb Vasc Biol (1997) 1.32

Human apolipoprotein A-I and A-II metabolism. J Lipid Res (1982) 1.32

The amino acid sequence of porcine thyrocalcitonin. Proc Natl Acad Sci U S A (1968) 1.31

Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol (1995) 1.31

Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E. Science (1981) 1.29

Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients. J Clin Invest (1986) 1.28

Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis. Proc Natl Acad Sci U S A (1996) 1.27

Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A (2000) 1.26

Sexual maturation and obesity in 9- and 10-year-old black and white girls: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr (1994) 1.26

The association of LDL receptor activity, LDL cholesterol level, and clinical course in homozygous familial hypercholesterolemia. Metabolism (1985) 1.23

Metabolism of high-density lipoprotein apolipoproteins in Tangier disease. N Engl J Med (1978) 1.23

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc Natl Acad Sci U S A (1994) 1.22

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells. Proc Natl Acad Sci U S A (1996) 1.22

Human parathyroid hormone: amino-acid sequence of the amino-terminal residues 1-34. Proc Natl Acad Sci U S A (1972) 1.22

The complete amino acid sequence of alanine apolipoprotein (apoC-3), and apolipoprotein from human plasma very low density lipoproteins. J Biol Chem (1974) 1.22

The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females. J Clin Endocrinol Metab (1983) 1.22

Adrenal cholesterol uptake from plasma lipoproteins: regulation by corticotropin. Proc Natl Acad Sci U S A (1976) 1.21

Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice. J Biol Chem (1999) 1.21

Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice. J Biol Chem (2001) 1.21

Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia. J Clin Invest (1982) 1.20

Regulation of liver 3-hydroxy-3-methylglutaryl-CoA reductase. Curr Top Cell Regul (1981) 1.20

Characterization of hepatic low density lipoprotein binding and cholesterol metabolism in normal and homozygous familial hypercholesterolemic subjects. J Clin Invest (1984) 1.18

Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol (1998) 1.18

Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis. Proc Natl Acad Sci U S A (1999) 1.18

Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production. J Clin Invest (1993) 1.17

Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles. Trends Cell Biol (1995) 1.17

3-Hydroxy-3-methylglutaryl--coenzyme A reductase inhibitors in the treatment of hypercholesterolemia. JAMA (1987) 1.17

Lipid-protein interactions in high density lipoproteins. Proc Natl Acad Sci U S A (1974) 1.17

Two-dimensional electrophoresis of human plasma apolipoproteins. Clin Chem (1984) 1.17

Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency. J Clin Invest (1990) 1.16

Cholesteryl ester storage disease and Wolman disease: phenotypic variants of lysosomal acid cholesteryl ester hydrolase deficiency. Am J Hum Genet (1984) 1.15

New micromethod for measuring cholesterol in plasma lipoprotein fractions. Clin Chem (1977) 1.15

The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate. J Clin Invest (1994) 1.14

Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL. J Biol Chem (1997) 1.13

Plasma-triglycerides in regulation of H.D.L.-cholesterol levels. Lancet (1978) 1.13

Identification of a novel in-frame translational stop codon in human intestine apoB mRNA. Biochem Biophys Res Commun (1987) 1.13

Analysis of the apolipoprotein B gene and messenger ribonucleic acid in abetalipoproteinemia. J Clin Invest (1986) 1.13

Apolipoprotein EBethesda: a new variant of apolipoprotein E associated with type III hyperlipoproteinemia. J Clin Endocrinol Metab (1983) 1.13

The molecular biology of human apoA-I, apoA-II, apoC-II and apoB. Adv Exp Med Biol (1986) 1.12

Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen. Proc Natl Acad Sci U S A (1977) 1.11

Lipoprotein abnormalities in primary biliary cirrhosis. Association with hepatic lipase inhibition as well as altered cholesterol esterification. Gastroenterology (1985) 1.11

Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J Biol Chem (1996) 1.11

Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicol Appl Pharmacol (1997) 1.10

Erdheim-Chester disease: a rare multisystem histiocytic disorder associated with interstitial lung disease. Am J Med Sci (2001) 1.10