Published in PLoS One on January 05, 2017
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science (1999) 24.31
Complete replication of hepatitis C virus in cell culture. Science (2005) 18.59
Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol (2002) 11.99
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74
Unravelling hepatitis C virus replication from genome to function. Nature (2005) 5.25
The structure and function of telomerase reverse transcriptase. Annu Rev Biochem (2006) 3.32
Telomerase in the human organism. Oncogene (2002) 3.30
The biogenesis and regulation of telomerase holoenzymes. Nat Rev Mol Cell Biol (2006) 2.94
Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines. J Virol (2000) 2.89
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell (2009) 2.60
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res (1998) 2.54
Telomerase: an RNP enzyme synthesizes DNA. Cold Spring Harb Perspect Biol (2011) 2.43
RNA binding domain of telomerase reverse transcriptase. Mol Cell Biol (2001) 2.27
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly. Cell (2008) 2.20
Heme oxygenase-1 suppresses hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury. Hepatology (2008) 1.94
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci (2008) 1.91
How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures. EMBO Rep (2005) 1.80
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target. Curr Issues Mol Biol (2007) 1.76
Biliverdin inhibits hepatitis C virus nonstructural 3/4A protease activity: mechanism for the antiviral effects of heme oxygenase? Hepatology (2010) 1.75
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate. J Biol Chem (2007) 1.70
The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently. J Biol Chem (2003) 1.61
Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase 3-dependent pathway. J Virol (2008) 1.60
Telomerase activity in human liver tissues: comparison between chronic liver disease and hepatocellular carcinomas. Cancer Res (1995) 1.60
Viral and cellular RNA helicases as antiviral targets. Nat Rev Drug Discov (2005) 1.59
Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem (2010) 1.58
Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene (2011) 1.56
One-step affinity purification protocol for human telomerase. Nucleic Acids Res (1998) 1.55
Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology (2000) 1.55
Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis. Cancer Genet Cytogenet (1997) 1.52
Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase. J Biol Chem (2008) 1.50
Candidate tumor suppressor DDX3 RNA helicase specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein. Oncogene (2007) 1.47
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Association of RNA helicase a with human immunodeficiency virus type 1 particles. J Biol Chem (2006) 1.37
Hepatitis C virus infection and apoptosis. World J Gastroenterol (2007) 1.36
Hepatitis C virus core protein: intriguing properties and functional relevance. FEMS Microbiol Lett (2001) 1.35
The current understanding of Ded1p/DDX3 homologs from yeast to human. RNA Biol (2009) 1.30
The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. Nucleic Acids Res (2003) 1.27
Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol (2005) 1.26
Regulation of telomerase and telomeres: human tumor viruses take control. J Natl Cancer Inst (2008) 1.24
DDX3 DEAD-Box RNA helicase inhibits hepatitis B virus reverse transcription by incorporation into nucleocapsids. J Virol (2009) 1.14
Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. J Infect Dis (2004) 1.13
A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity. Nucleic Acids Res (2009) 1.12
Direct-acting antiviral agents and the path to interferon independence. Clin Gastroenterol Hepatol (2013) 1.12
Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes. Virology (2002) 1.08
DEAD box RNA helicase functions in cancer. RNA Biol (2013) 1.06
The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase. J Biol Chem (2010) 1.06
Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure (2012) 1.05
RNA helicases in infection and disease. RNA Biol (2012) 1.05
The 5' guanosine tracts of human telomerase RNA are recognized by the G-quadruplex binding domain of the RNA helicase DHX36 and function to increase RNA accumulation. Mol Cell Biol (2010) 1.04
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res (2011) 1.04
Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria. Front Oncol (2012) 1.02
The NS3 protein of hepatitis C virus induces caspase-8-mediated apoptosis independent of its protease or helicase activities. Virology (2004) 1.02
Expression of human telomerase reverse transcriptase in regenerative and precancerous lesions of cirrhotic livers. Liver (2002) 0.92
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Mol Cell Proteomics (2013) 0.92
Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. J Virol (2011) 0.91
The telomerase cycle: normal and pathological aspects. J Mol Med (Berl) (2005) 0.90
Molecular regulation of telomerase activity in aging. Protein Cell (2011) 0.90
The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism. J Nucleic Acids (2010) 0.88
Hepatitis C and hepatocellular carcinoma. Ann Hepatol (2010) 0.87
Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP. PLoS One (2011) 0.87
Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection. Aging Cell (2011) 0.85
Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase. Histochem Cell Biol (2013) 0.85
RNA binding by the NS3 protease of the hepatitis C virus. Virus Res (2012) 0.82
Hepatitis C virus core protein enhances Telomerase activity in Huh7 cells. J Med Virol (2010) 0.82
Subcellular localisation of NS3 in HCV-infected hepatocytes. J Med Virol (1999) 0.81
Hepatitis C virus nonstructural protein NS(3) and telomerase activity. Chin Med J (Engl) (2002) 0.81
Restoration of type I interferon expression by heme and related tetrapyrroles through inhibition of NS3/4A protease. J Infect Dis (2013) 0.79
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate. Biochemistry (2011) 0.78