The Tumor Microenvironment Modulates Choline and Lipid Metabolism.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28066718)

Published in Front Oncol on December 22, 2016

Authors

Noriko Mori1, Flonné Wildes1, Tomoyo Takagi1, Kristine Glunde2, Zaver M Bhujwalla2

Author Affiliations

1: JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science , Baltimore, MD , USA.
2: JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, The Johns Hopkins University, Baltimore, MD, USA.

Articles citing this

Breast Tissue Metabolism by Magnetic Resonance Spectroscopy. Metabolites (2017) 0.79

Articles cited by this

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer (2007) 10.20

Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res (1999) 3.23

MRI of the tumor microenvironment. J Magn Reson Imaging (2002) 2.87

Choline metabolism in malignant transformation. Nat Rev Cancer (2011) 2.85

Metabolism of lipides. Annu Rev Biochem (1957) 2.83

Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res (2004) 2.43

Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer Res (2005) 2.11

Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene (2002) 2.09

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer (2009) 2.05

Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol (1997) 1.93

Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res (2001) 1.82

RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. Cancer Res (2005) 1.77

Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol (1997) 1.76

Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin Cancer Res (1997) 1.70

Overexpression of phospholipase D1 in human breast cancer tissues. Cancer Lett (2000) 1.70

Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol (1996) 1.68

Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells. Cancer Res (2010) 1.65

Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts. Neoplasia (2001) 1.56

Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res (2004) 1.49

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models. BMC Cancer (2010) 1.46

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci U S A (2012) 1.41

The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist. Adv Physiol Educ (2007) 1.29

Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells. Cancer Res (2007) 1.27

Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft. Cancer Res (2009) 1.27

Applications of magnetic resonance in model systems: tumor biology and physiology. Neoplasia (2000) 1.25

MR evaluation of response to targeted treatment in cancer cells. NMR Biomed (2011) 1.14

Fatty acid synthase (FAS) expression in human breast cancer cell culture supernatants and in breast cancer patients. Cancer Lett (2001) 1.10

In vivo 1H MRS of normal breast and breast tumors using a dedicated double breast coil. J Magn Reson Imaging (1999) 1.10

Characterization of lipid composition in stimulated human lymphocytes by 1H-NMR. Biochim Biophys Acta (1990) 1.09

The role of phosphatidylcholine and choline metabolites to cell proliferation and survival. Crit Rev Biochem Mol Biol (2013) 1.02

Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR Biomed (2012) 0.99

Phospholipase D1 and choline kinase-α are interactive targets in breast cancer. Cancer Biol Ther (2014) 0.98

Metabolic mapping by use of high-resolution magic angle spinning 1H MR spectroscopy for assessment of apoptosis in cervical carcinomas. BMC Cancer (2007) 0.98

Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications. Int J Clin Exp Pathol (2010) 0.96

Real-time changes in 1H and 31P NMR spectra of malignant human mammary epithelial cells during treatment with the anti-inflammatory agent indomethacin. Magn Reson Med (2002) 0.96

Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma. Int J Clin Exp Pathol (2010) 0.95

Nuclear receptors, transcription factors linking lipid metabolism and immunity: the case of peroxisome proliferator-activated receptor gamma. Eur J Clin Invest (2008) 0.94

Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS. NMR Biomed (2010) 0.92

Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity. Exp Cell Res (2013) 0.90

1H-NMR studies of lipid extracts of rat liver mitochondria. Biochem Biophys Res Commun (1991) 0.86

Tumor-stroma crosstalk: targeting stroma in breast cancer. Curr Opin Oncol (2014) 0.83

Characterization of choline kinase in human endothelial cells. NMR Biomed (2013) 0.82

Choline phospholipid metabolites of human vascular endothelial cells altered by cyclooxygenase inhibition, growth factor depletion, and paracrine factors secreted by cancer cells. Mol Imaging (2003) 0.82

Magnetic resonance spectroscopy of cellular lipid extracts from sensitive, resistant and reverting K562 cells and flow cytometry for investigating the P-glycoprotein function in resistance reversion. NMR Biomed (2000) 0.81

Increase of GPC levels in cultured mammalian cells during acidosis. A 31P MR spectroscopy study using a continuous bioreactor system. Magn Reson Med (1995) 0.79

COX-2 dependent regulation of mechanotransduction in human breast cancer cells. Cancer Biol Ther (2015) 0.76

Lymphatic endothelial cells actively regulate prostate cancer cell invasion. NMR Biomed (2016) 0.76