Deubiquitylation of hepatitis B virus X protein (HBx) by ubiquitin-specific peptidase 15 (USP15) increases HBx stability and its transactivation activity.

HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34

Hepatitis B virus X protein: a multifunctional viral regulator. J Gastroenterol (2001) 1.98

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma. Nat Med (2012) 1.93

Hepatitis B virus-induced oncogenesis. World J Gastroenterol (2007) 1.82

High-level expression of hepatitis B virus HBx gene and hepatocarcinogenesis in transgenic mice. Hepatology (1994) 1.74

Effects of hepatitis B virus X protein on the development of liver cancer. J Lab Clin Med (2006) 1.70

CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha. EMBO J (2007) 1.66

USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol (2011) 1.61

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proc Natl Acad Sci U S A (2004) 1.59

Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex. J Virol (1999) 1.57

The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Curr Biol (2005) 1.55

Hepatocellular carcinoma (HCC): a global perspective. J Clin Gastroenterol (2010) 1.49

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Hum Mol Genet (2014) 1.41

A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function. Proc Natl Acad Sci U S A (1996) 1.18

The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25. Sci Signal (2014) 1.15

Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus. Oncogene (1991) 1.14

The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15. J Mol Biol (2009) 1.13

USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. Cell Signal (2010) 1.09

Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Genomics (1999) 1.09

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol (2014) 1.06

The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability. J Virol (2009) 1.00

Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells. Curr Biol (2009) 0.95

Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins. J Gen Virol (2006) 0.94

Two ZnF-UBP domains in isopeptidase T (USP5). Biochemistry (2012) 0.93

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling. Open Biol (2014) 0.93

RNA interference targeting HBx suppresses tumor growth and enhances cisplatin chemosensitivity in human hepatocellular carcinoma. Cancer Lett (2007) 0.93

USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis. Biochem Biophys Res Commun (2009) 0.92

Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma. World J Gastroenterol (2014) 0.91

Hepatitis B virus core protein stimulates the proteasome-mediated degradation of viral X protein. J Virol (2003) 0.90

Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis. Int J Oncol (2005) 0.89

Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms. Sci Rep (2015) 0.89

Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15. Int J Biochem Cell Biol (2014) 0.86

Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx. Cancer Lett (2009) 0.86

Hepatitis B virus X protein enhances activation of nuclear factor κB through interaction with valosin-containing protein. Arch Virol (2011) 0.85

Hepatitis B virus HBx protein interactions with the ubiquitin proteasome system. Viruses (2014) 0.84

E3 ubiquitin ligase Siah-1 facilitates poly-ubiquitylation and proteasomal degradation of the hepatitis B viral X protein. FEBS Lett (2011) 0.84

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2. Mol Biol Rep (2009) 0.82

Hepatitis B doubly spliced protein, generated by a 2.2 kb doubly spliced hepatitis B virus RNA, is a pleiotropic activator protein mediating its effects via activator protein-1- and CCAAT/enhancer-binding protein-binding sites. J Gen Virol (2010) 0.81

Id-1 induces proteasome-dependent degradation of the HBX protein. J Mol Biol (2007) 0.81

Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT). Virus Res (2014) 0.77

USP15 stabilizes the transcription factor Nrf1 in the nucleus, promoting the proteasome gene expression. Biochem Biophys Res Commun (2016) 0.76

DDAH1 mediates gastric cancer cell invasion and metastasis via Wnt/β-catenin signaling pathway. Mol Oncol (2017) 0.75