Published in PLoS One on January 11, 2017
The neurobiology of antiepileptic drugs. Nat Rev Neurosci (2004) 3.24
An overview of drug combination analysis with isobolograms. J Pharmacol Exp Ther (2006) 2.82
Epilepsy after the first drug fails: substitution or add-on? Seizure (2000) 2.19
Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J Neurophysiol (1988) 2.15
When one plus one makes three: the quest for rational antiepileptic polytherapy with supraadditive anticonvulsant efficacy. Epilepsy Behav (2013) 2.14
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs (2002) 2.13
Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action. Prog Neurobiol (1999) 1.80
Epileptiform activity induced by changes in extracellular potassium in hippocampus. J Neurophysiol (1985) 1.51
Periodic EEG patterns: importance of their recognition and clinical significance. Arq Neuropsiquiatr (2012) 1.50
Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Res (1997) 1.49
Mechanisms of action of valproate: a commentatory. Neurochem Int (2000) 1.48
A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels. Mol Pharmacol (1998) 1.41
Morphological patterns of seizures recorded intracranially. Epilepsia (1992) 1.26
Definition of refractory epilepsy: defining the indefinable? Lancet Neurol (2009) 1.16
Rational polytherapy. Epilepsia (2009) 1.13
Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology. Brain (2013) 1.11
Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose-response curves. J Pharmacol Methods (1980) 1.11
The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. Epilepsia (1999) 1.11
Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy. Epilepsia (2006) 1.10
Analysis of drug combinations: current methodological landscape. Pharmacol Res Perspect (2015) 1.08
The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. Br J Clin Pharmacol (1986) 1.07
Lamotrigine inhibits postsynaptic AMPA receptor and glutamate release in the dentate gyrus. Epilepsia (2008) 1.00
Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine. Epilepsia (2004) 0.97
Combining immunotherapy and anticancer agents: the right path to achieve cancer cure? Ann Oncol (2015) 0.97
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. J Neurophysiol (2012) 0.95
Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices. Exp Brain Res (1993) 0.93
Synergism of lacosamide with established antiepileptic drugs in the 6-Hz seizure model in mice. Epilepsia (2013) 0.93
Antiepileptic drug cellular mechanisms of action: where does lamotrigine fit in? J Child Neurol (1997) 0.92
How can we identify ictal and interictal abnormal activity? Adv Exp Med Biol (2014) 0.90
Spatiotemporal dynamics of high-K+-induced epileptiform discharges in hippocampal slice and the effects of valproate. Neurosci Bull (2013) 0.89
Isobolographic analysis of the mechanisms of action of anticonvulsants from a combination effect. Eur J Pharmacol (2014) 0.89
Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action. JAMA Neurol (2014) 0.88
The clinical pharmacology of traditional antiepileptic drugs. Epileptic Disord (2014) 0.86
Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons. Epilepsy Res (1998) 0.85
Shortcomings in the current treatment of epilepsy. Expert Rev Neurother (2012) 0.85
Serial EEG during human status epilepticus: evidence for PLED as an ictal pattern. Neurology (2001) 0.84
What are the arguments for and against rational therapy for epilepsy? Adv Exp Med Biol (2014) 0.84
Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs. Epileptic Disord (2014) 0.84
Phenytoin inhibits the persistent sodium current in neocortical neurons by modifying its inactivation properties. PLoS One (2013) 0.83
Pathogenesis of epilepsy: challenges in animal models. Iran J Basic Med Sci (2013) 0.83
Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis. Epilepsia (2003) 0.83
Anticancer drugs: Finding the perfect combination. Nat Rev Drug Discov (2015) 0.82
Current challenges in the management of epilepsy. Am J Manag Care (2011) 0.82
Antiepileptic action induced by a combination of vigabatrin and tiagabine. Neuroscience (2005) 0.81
Hippocampus and epilepsy: Findings from human tissues. Rev Neurol (Paris) (2015) 0.80
Do antiepileptic drugs differ in suppressing interictal epileptiform activity in children? Pediatr Neurol (2001) 0.80
In vitro seizure like events and changes in ionic concentration. J Neurosci Methods (2015) 0.79
Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography. Expert Opin Drug Metab Toxicol (2009) 0.79
Limbic networks and epileptiform synchronization: the view from the experimental side. Int Rev Neurobiol (2014) 0.79
Simeprevir and sofosbuvir for treatment of hepatitis C infection. Am J Health Syst Pharm (2015) 0.78
Seizure-freedom with combination therapy in localization-related epilepsy. Seizure (2007) 0.78
Effect of valproate, lamotrigine and levetiracetam on excitability and firing properties of CA1 neurons in rat brain slices. Cell Mol Neurobiol (2011) 0.77
Electrophysiologic analysis of the actions of valproate on pyramidal neurons in the rat hippocampal slice. Epilepsia (1998) 0.77
The anti-ictogenic effects of levetiracetam are mirrored by interictal spiking and high-frequency oscillation changes in a model of temporal lobe epilepsy. Seizure (2014) 0.77
Lacosamide modulates interictal spiking and high-frequency oscillations in a model of mesial temporal lobe epilepsy. Epilepsy Res (2015) 0.76
A narrative review of cost-effectiveness analysis of people living with HIV treated with HAART: from interventions to outcomes. Clinicoecon Outcomes Res (2015) 0.76
Would Sherlock Holmes agree with our definition of rational polytherapy? A proposal for a national data bank on patients with epilepsy. Epilepsy Behav (2015) 0.76