A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.

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🔗 View Article (PMID 28082416)

Published in Neuro Oncol on January 12, 2017

Authors

Yu Sun1,2, John A Alberta1,2, Catherine Pilarz1,2, David Calligaris3, Emily J Chadwick1,2, Shakti H Ramkissoon4,5, Lori A Ramkissoon4, Veronica Matia Garcia1,2, Emanuele Mazzola6, Liliana Goumnerova7, Michael Kane1,2, Zhan Yao8, Mark W Kieran9,10, Keith L Ligon4,5, William C Hahn11,12, Levi A Garraway11,12, Neal Rosen8, Nathanael S Gray2,13, Nathalie Y Agar3,14,15, Sara J Buhrlage2,13, Rosalind A Segal1,2,10, Charles D Stiles1,2

Author Affiliations

1: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
2: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
3: Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
4: Center for Molecular Oncologic Pathology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
5: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
6: Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
7: Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
8: Program in Molecular Pharmacology, Department of Medicine, and Center for Mechanism Based Therapeutics Memorial Sloan Kettering Cancer Center, New York, USA.
9: Division of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, Massachusetts, USA.
10: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
11: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
12: The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
13: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
14: Departments of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
15: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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