Controlling multi-cycle replication of live-attenuated HIV-1 using an unnatural genetic switch.

Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science (1992) 9.30

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature (1998) 6.94

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity (1999) 6.80

Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science (1995) 6.30

RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. J Mol Diagn (2012) 4.63

Environmentally controlled invasion of cancer cells by engineered bacteria. J Mol Biol (2005) 4.25

Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J Virol (1996) 3.84

Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (2009) 3.69

HIV vaccine design: insights from live attenuated SIV vaccines. Nat Immunol (2006) 2.72

Recoded organisms engineered to depend on synthetic amino acids. Nature (2015) 2.71

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus. J Exp Med (2008) 2.59

Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1. J Virol (2007) 2.52

Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. J Virol (1998) 2.49

Biocontainment of genetically modified organisms by synthetic protein design. Nature (2015) 2.06

Viral evolution as a tool to improve the tetracycline-regulated gene expression system. J Biol Chem (2004) 2.06

Strict control of human immunodeficiency virus type 1 replication by a genetic switch: Tet for Tat. J Virol (2001) 1.89

25 years of HIV. Nature (2008) 1.83

Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science (2016) 1.74

Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge. J Virol (2010) 1.66

Regulation of transcription by unnatural amino acids. Nat Biotechnol (2011) 1.64

Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. AIDS (2003) 1.50

In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies. Proc Natl Acad Sci U S A (2001) 1.40

Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus. Proc Natl Acad Sci U S A (2004) 1.30

Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239. J Virol (2005) 1.17

A conditionally replicating virus as a novel approach toward an HIV vaccine. Methods Enzymol (2004) 1.05

A novel approach for producing lentiviruses that are limited to a single cycle of infection. J Virol (2004) 1.03

Constitutively dead, conditionally live HIV-1 genomes. Ex vivo implications for a live virus vaccine. J Biol Chem (2001) 1.02

The genetic stability of a conditional live HIV-1 variant can be improved by mutations in the Tet-On regulatory system that restrain evolution. J Biol Chem (2006) 0.98

Modification of the Tet-On regulatory system prevents the conditional-live HIV-1 variant from losing doxycycline-control. Retrovirology (2006) 0.95

Single-cycle immunodeficiency viruses provide strategies for uncoupling in vivo expression levels from viral replicative capacity and for mimicking live-attenuated SIV vaccines. Virology (2003) 0.92

A genetically encoded fluorescent probe in mammalian cells. J Am Chem Soc (2013) 0.91

Conditional live virus as a novel approach towards a safe live attenuated HIV vaccine. Expert Rev Vaccines (2002) 0.87

Control over HIV-1 replication by an antibiotic; a novel vaccination strategy with a drug-dependent virus. Virus Res (2002) 0.87

Role of complement and antibodies in controlling infection with pathogenic simian immunodeficiency virus (SIV) in macaques vaccinated with replication-deficient viral vectors. Retrovirology (2009) 0.84

Construction of a live-attenuated HIV-1 vaccine through genetic code expansion. Angew Chem Int Ed Engl (2014) 0.80

Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice. J Virol (2016) 0.78

Evolution of Src Homology 2 (SH2) Domain to Recognize Sulfotyrosine. ACS Chem Biol (2016) 0.76