Published in Redox Biol on January 16, 2017
The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science (2009) 18.82
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Control of the embryonic stem cell state. Cell (2011) 6.89
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature (2011) 6.21
Parkinson's disease. First of two parts. N Engl J Med (1998) 5.90
MicroRNA-mediated conversion of human fibroblasts to neurons. Nature (2011) 5.59
Dopamine neuron agenesis in Nurr1-deficient mice. Science (1997) 5.40
Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A (2011) 4.81
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell (2011) 4.65
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev (2011) 4.09
Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development (2000) 3.96
Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell (2011) 3.62
Parkinson's disease. Second of two parts. N Engl J Med (1998) 3.46
Identification of intrinsic determinants of midbrain dopamine neurons. Cell (2006) 3.31
Direct conversion of C. elegans germ cells into specific neuron types. Science (2010) 3.31
Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods (2012) 2.64
Generation of oligodendroglial cells by direct lineage conversion. Nat Biotechnol (2013) 2.64
Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol (2010) 2.60
In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat Cell Biol (2013) 2.56
Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol (2013) 2.53
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
How to make a mesodiencephalic dopaminergic neuron. Nat Rev Neurosci (2007) 2.33
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. Cell Stem Cell (2013) 2.26
Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev (2002) 2.19
Genetic analysis of pathways to Parkinson disease. Neuron (2010) 2.15
Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell (2015) 2.02
Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports. JAMA Neurol (2014) 2.00
Functional integration of dopaminergic neurons directly converted from mouse fibroblasts. Cell Stem Cell (2011) 1.95
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell (2015) 1.79
Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell (2012) 1.76
Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease. Lancet Neurol (2013) 1.72
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun (2013) 1.69
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res (2011) 1.67
Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods (2012) 1.58
Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease. Cell Stem Cell (2014) 1.52
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex. Nat Protoc (2011) 1.49
Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports (2014) 1.45
Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex. Stem Cell Reports (2014) 1.38
In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun (2014) 1.38
Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity. Nat Neurosci (2013) 1.36
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nat Commun (2012) 1.33
Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Res (2014) 1.30
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells. Cell Res (2011) 1.26
Remote control of induced dopaminergic neurons in parkinsonian rats. J Clin Invest (2014) 1.23
MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. Curr Biol (1997) 1.12
Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron (2014) 1.11
Conversion of myoblasts to physiologically active neuronal phenotype. Genes Dev (2004) 1.11
Direct conversion of human fibroblasts to induced serotonergic neurons. Mol Psychiatry (2015) 1.01
Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo. J Neurosci (2015) 0.99
Cell-based therapies for Parkinson disease—past insights and future potential. Nat Rev Neurol (2015) 0.97
Generation of functional human serotonergic neurons from fibroblasts. Mol Psychiatry (2015) 0.96
Transcriptional control of the terminal fate of monoaminergic neurons. Annu Rev Neurosci (2011) 0.95
In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry. Cell Rep (2015) 0.93
Direct reprogramming of melanocytes to neural crest stem-like cells by one defined factor. Stem Cells (2011) 0.91
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons. Nat Commun (2015) 0.90
Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep (2015) 0.90
Selective conversion of fibroblasts into peripheral sensory neurons. Nat Neurosci (2014) 0.89
Rapid and Efficient Direct Conversion of Human Adult Somatic Cells into Neural Stem Cells by HMGA2/let-7b. Cell Rep (2015) 0.89
Senescence impairs direct conversion of human somatic cells to neurons. Nat Commun (2014) 0.88
Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells. Stem Cell Reports (2014) 0.87
Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain. Sci Rep (2014) 0.86
The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease. Curr Top Med Chem (2009) 0.85
Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming. Development (2016) 0.84
Nanogrooved substrate promotes direct lineage reprogramming of fibroblasts to functional induced dopaminergic neurons. Biomaterials (2015) 0.84
Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. J Neurosci Methods (2013) 0.83
Direct conversion of astrocytes into neuronal cells by drug cocktail. Cell Res (2015) 0.82
Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation. Mol Neurobiol (2015) 0.82
Direct neural conversion from human fibroblasts using self-regulating and nonintegrating viral vectors. Cell Rep (2014) 0.82
Brief azacytidine step allows the conversion of suspension human fibroblasts into neural progenitor-like cells. Cell J (2015) 0.82
Highly efficient direct conversion of human fibroblasts to neuronal cells by chemical compounds. J Clin Biochem Nutr (2015) 0.82
Enhancing the efficiency of direct reprogramming of human mesenchymal stem cells into mature neuronal-like cells with the combination of small molecule modulators of chromatin modifying enzymes, SMAD signaling and cyclic adenosine monophosphate levels. Int J Biochem Cell Biol (2013) 0.81
Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors. Mol Brain (2014) 0.81
Lineage-reprogramming of pericyte-derived cells of the adult human brain into induced neurons. J Vis Exp (2014) 0.80
Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports (2014) 0.80
Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage. J Biol Chem (2015) 0.80
Direct Conversion of Cord Blood CD34+ Cells Into Neural Stem Cells by OCT4. Stem Cells Transl Med (2015) 0.80
Induction of retinal progenitors and neurons from mammalian Müller glia under defined conditions. J Biol Chem (2014) 0.80
Direct reprogramming of porcine fibroblasts to neural progenitor cells. Protein Cell (2014) 0.80
Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities. Neurosci Res (2015) 0.79
MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons. Nat Protoc (2015) 0.79
Conversion of fibroblasts to neural cells by p53 depletion. Cell Rep (2014) 0.78
Direct induction of human neural stem cells from peripheral blood hematopoietic progenitor cells. J Vis Exp (2015) 0.78
Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression. Sci China Life Sci (2014) 0.78
Direct conversion of human fibroblasts into dopaminergic neural progenitor-like cells using TAT-mediated protein transduction of recombinant factors. Biochem Biophys Res Commun (2015) 0.78
Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellum. Stem Cells (2010) 0.78
Generation of induced neurons by direct reprogramming in the mammalian cochlea. Neuroscience (2014) 0.78
Analysis of Mll1 deficiency identifies neurogenic transcriptional modules and Brn4 as a factor for direct astrocyte-to-neuron reprogramming. Neurosurgery (2014) 0.78
Induction of neural differentiation in rat C6 glioma cells with taxol. Brain Behav (2015) 0.77
Efficient reprogramming of mouse fibroblasts to neuronal cells including dopaminergic neurons. ScientificWorldJournal (2014) 0.77
Reprogramming somatic cells to cells with neuronal characteristics by defined medium both in vitro and in vivo. Cell Regen (Lond) (2015) 0.77
Direct Reprogramming of Mouse Fibroblasts to Neural Stem Cells by Small Molecules. Stem Cells Int (2015) 0.77
MicroRNA 302/367 Cluster Effectively Facilitates Direct Reprogramming from Human Fibroblasts into Functional Neurons. Stem Cells Dev (2015) 0.77
Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion. Sci Rep (2015) 0.77
Kinetic barriers in transdifferentiation. Cell Cycle (2016) 0.76
Direct conversion of mouse fibroblasts to GABAergic neurons with combined medium without the introduction of transcription factors or miRNAs. Cell Cycle (2015) 0.76
Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors. Stem Cell Res (2016) 0.75
Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons. Stem Cells Int (2015) 0.75