Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity.

Author Affiliations

1: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, China National Research Center for Metabolic Diseases, National Key Laboratory for Medical Genomes, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
2: Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), and Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
3: Department of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
4: Department of Pediatrics, Peking University First Hospital, Beijing, China.
5: Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
6: Department of Epidemiology and Center for Global Cardiometabolic Health, School of Public Health, and Department of Medicine (Endocrinology), The Warren Alpert Medical School, Brown University, Providence, RI.
7: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.
8: State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.
9: Department of Nutrition, Harvard School of Public Health, Boston, MA.
10: Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD.
11: The Institute of Neuroscience, Zhejiang University, Hangzhou, China.
12: College of Life Sciences, the Institute for Advanced Studies, Wuhan University, Wuhan, China.
13: Department of Epidemiology and Center for Global Cardiometabolic Health, School of Public Health, and Department of Medicine (Endocrinology), The Warren Alpert Medical School, Brown University, Providence, RI wangjq@shsmu.edu.cn gning@sibs.ac.cn wqingw@hotmail.com simin_liu@brown.edu.
14: Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, China National Research Center for Metabolic Diseases, National Key Laboratory for Medical Genomes, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China wangjq@shsmu.edu.cn gning@sibs.ac.cn wqingw@hotmail.com simin_liu@brown.edu.