HIV viral kinetics and T cell dynamics in antiretroviral naïve persons starting an integrase strand transfer inhibitor and protease inhibitor regimen.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28134057)

Published in HIV Clin Trials on January 30, 2017

Authors

Maile Y Karris1, Sonia Jain2, Tyler R C Day3, Josué Pérez-Santiago1, Miguel Goicoechea4, Michael P Dubé5, Xiaoying Sun2, Celsa Spina6, Eric S Daar7,8, Richard H Haubrich9, Sheldon Morris1,2, California Collaborative Treatment Group (CCTG) 589 Study Team

Author Affiliations

1: a Department of Medicine , University California San Diego , San Diego , CA , USA.
2: b Department of Family and Preventive Medicine , University California San Diego , San Diego , CA , USA.
3: c Department of Medicine , Washington University , Saint Louis , MO , USA.
4: d Department of Medicine , Scripps Health San Diego , CA , USA.
5: e Department of Medicine , University Southern California Keck School of Medicine , Los Angeles , CA , USA.
6: f Department of Pathology , Veterans Affairs San Diego Healthcare System , San Diego , CA , USA.
7: g Los Angeles Biomedical Research Institute , Harbor-UCLA Medical Center , Los Angeles , CA , USA.
8: h David Geffen School of Medicine , UCLA , Los Angeles , CA , USA.
9: i Gilead Sciences , Forest city , CA , USA.

Articles cited by this

Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med (2011) 69.36

Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med (2008) 8.50

HIV infection, inflammation, immunosenescence, and aging. Annu Rev Med (2011) 6.30

Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis (2011) 4.79

Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment. AIDS (2009) 2.91

HIV latency. Cold Spring Harb Perspect Med (2011) 2.90

Guideline for flow cytometric immunophenotyping: a report from the National Institute of Allergy and Infectious Diseases, Division of AIDS. Cytometry (1993) 2.77

Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J Clin Invest (1997) 2.69

Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med (2009) 2.30

Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS (2007) 2.27

Ritonavir-boosted lopinavir plus nucleoside or nucleotide reverse transcriptase inhibitors versus ritonavir-boosted lopinavir plus raltegravir for treatment of HIV-1 infection in adults with virological failure of a standard first-line ART regimen (SECOND-LINE): a randomised, open-label, non-inferiority study. Lancet (2013) 2.23

Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262). AIDS (2011) 2.22

Ritonavir-boosted darunavir combined with raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial. Lancet (2014) 1.92

Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents. AIDS (2012) 1.90

Cardiovascular risks associated with abacavir and tenofovir exposure in HIV-infected persons. AIDS (2011) 1.57

Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation. J Virol (1995) 1.51

Bone mineral density and inflammatory and bone biomarkers after darunavir-ritonavir combined with either raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults with HIV-1: a substudy of the NEAT001/ANRS143 randomised trial. Lancet HIV (2015) 1.49

Lopinavir/ritonavir combined with raltegravir or tenofovir/emtricitabine in antiretroviral-naive subjects: 96-week results of the PROGRESS study. AIDS Res Hum Retroviruses (2012) 1.36

Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr (2013) 1.31

Three distinct phases of HIV-1 RNA decay in treatment-naive patients receiving raltegravir-based antiretroviral therapy: ACTG A5248. J Infect Dis (2013) 1.26

A review of the toxicity of HIV medications. J Med Toxicol (2014) 1.19

Stage-dependent inhibition of HIV-1 replication by antiretroviral drugs in cell culture. Antimicrob Agents Chemother (2009) 1.15

The role of the cell cycle in HIV-1 infection. Adv Exp Med Biol (1995) 1.13

A nucleoside- and ritonavir-sparing regimen containing atazanavir plus raltegravir in antiretroviral treatment-naïve HIV-infected patients: SPARTAN study results. HIV Clin Trials (2012) 1.13

HIV Transmission Risk Persists During the First 6 Months of Antiretroviral Therapy. J Acquir Immune Defic Syndr (2016) 1.02

Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine. PLoS One (2013) 1.01

Examination of noninferiority, safety, and tolerability of lopinavir/ritonavir and raltegravir compared with lopinavir/ritonavir and tenofovir/ emtricitabine in antiretroviral-naïve subjects: the progress study, 48-week results. HIV Clin Trials (2011) 0.94

Initial viral decay to assess the relative antiretroviral potency of protease inhibitor-sparing, nonnucleoside reverse transcriptase inhibitor-sparing, and nucleoside reverse transcriptase inhibitor-sparing regimens for first-line therapy of HIV infection. AIDS (2011) 0.92

Endocrine complications of human immunodeficiency virus infection: hypogonadism, bone disease and tenofovir-related toxicity. Best Pract Res Clin Endocrinol Metab (2011) 0.91

Use of Abacavir and Risk of Cardiovascular Disease Among HIV-Infected Individuals. J Acquir Immune Defic Syndr (2016) 0.89

Recovery of fat following a switch to nucleoside reverse transcriptase inhibitor-sparing therapy in patients with lipoatrophy: results from the 96-week randomized ANRS 108 NoNuke Trial. HIV Med (2008) 0.86

Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA). Clin Infect Dis (2009) 0.86

Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration. BMC Med (2016) 0.86

Transmitted antiretroviral drug resistance in New York State, 2006-2008: results from a new surveillance system. PLoS One (2012) 0.86

The impaired in vitro production of interleukin-2 in HIV infection is negatively correlated to the number of circulating CD4+DR+ T cells and is reversed by allowing T cells to rest in culture: arguments for in vivo CD4+ T cell activation. Clin Immunol Immunopathol (1993) 0.83

Does HIV antiretroviral therapy still need its backbone? Lancet (2014) 0.83

Early HIV RNA decay during raltegravir-containing regimens exhibits two distinct subphases (1a and 1b). AIDS (2015) 0.82

Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir. Antivir Ther (2011) 0.81

Renal and Bone Toxicity with the Use of Tenofovir: Understanding at the End. AIDS Rev (2016) 0.80

Prevalence of drug-resistant HIV type 1 at the time of initiation of antiretroviral therapy in Portland, Oregon. AIDS Res Hum Retroviruses (2012) 0.76

Nucleoside-Sparing Regimens With Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue. J Acquir Immune Defic Syndr (2016) 0.75

Articles by these authors

Nucleoside-Sparing Regimens With Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue. J Acquir Immune Defic Syndr (2016) 0.75