HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates.

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Published in J Virol on April 13, 2017

Authors

Juan García-Arriaza1, Beatriz Perdiguero1, Jonathan L Heeney2, Michael S Seaman3, David C Montefiori4, Nicole L Yates4, Georgia D Tomaras4, Guido Ferrari4, Kathryn E Foulds5, Mario Roederer5, Steven G Self6, Bhavesh Borate6, Raphael Gottardo6, Sanjay Phogat7, Jim Tartaglia7, Susan W Barnett8, Brian Burke8, Anthony D Cristillo9, Deborah E Weiss9, Carter Lee10, Karen V Kibler11, Bertram L Jacobs11, Ralf Wagner12, Song Ding13, Giuseppe Pantaleo14, Mariano Esteban15

Author Affiliations

1: Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
2: Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
3: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
4: Duke University Medical Center, Durham, North Carolina, USA.
5: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
6: Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
7: Sanofi Pasteur, Swiftwater, Pennsylvania, USA.
8: Novartis Vaccines and Diagnostics, Inc., Cambridge, Massachusetts, USA.
9: Advanced BioScience Laboratories, Inc., Rockville, Maryland, USA.
10: Global Solutions on Infectious Diseases, South San Francisco, California, USA.
11: Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
12: University of Regensburg, Regensburg, Germany.
13: EuroVacc Foundation, Lausanne, Switzerland.
14: Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
15: Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain mesteban@cnb.csic.es.

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