Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28194441)

Published in JCI Insight on February 09, 2017

Authors

Evalynn Vasquez1, Vivian Cristofaro2, Stefan Lukianov3, Fiona C Burkhard4, Ali Hashemi Gheinani4, Katia Monastyrskaya4, Diane R Bielenberg5, Maryrose P Sullivan2, Rosalyn M Adam1

Author Affiliations

1: Urological Diseases Research Center, Boston Children's Hospital,; Department of Surgery, Harvard Medical School.
2: Department of Surgery, Harvard Medical School,; Division of Urology, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA.
3: Urological Diseases Research Center, Boston Children's Hospital.
4: Urology Research Laboratory, Department of Clinical Research, Universität Bern, Bern, Switzerland.
5: Department of Surgery, Harvard Medical School,; Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.

Articles cited by this

Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev (2003) 9.32

Detrusor underactivity and the underactive bladder: a new clinical entity? A review of current terminology, definitions, epidemiology, aetiology, and diagnosis. Eur Urol (2013) 2.36

Blocking neuropilin-2 function inhibits tumor cell metastasis. Cancer Cell (2008) 2.35

Standardization of terminology of lower urinary tract function: pressure-flow studies of voiding, urethral resistance, and urethral obstruction. International Continence Society Subcommittee on Standardization of Terminology of Pressure-Flow Studies. Neurourol Urodyn (1997) 2.20

Temporally controlled somatic mutagenesis in smooth muscle. Genesis (2000) 2.01

Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med (2012) 1.99

Detrusor underactivity: a plea for new approaches to a common bladder dysfunction. Neurourol Urodyn (2011) 1.85

Prostaglandin E2 and bethanechol in combination for treating detrusor underactivity. BJU Int (2004) 1.55

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem (2008) 1.34

Bladder outlet obstruction: progression from inflammation to fibrosis. BJU Int (2010) 1.28

Aberrant sensory innervation of the olfactory bulb in neuropilin-2 mutant mice. J Neurosci (2002) 1.21

A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and Myosin isoform expression. J Urol (2004) 1.20

Is the use of parasympathomimetics for treating an underactive urinary bladder evidence-based? BJU Int (2007) 1.14

Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice. J Urol (2004) 1.09

Smooth muscle caveolae differentially regulate specific agonist induced bladder contractions. Neurourol Urodyn (2007) 1.05

Hypoxia induces tumor and endothelial cell migration in a semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor neuropilin 2. Cell Adh Migr (2011) 1.02

Null mutation in macrophage migration inhibitory factor prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. Am J Physiol Renal Physiol (2006) 0.97

Semaphorin-induced cytoskeletal collapse and repulsion of endothelial cells. Methods Enzymol (2008) 0.93

An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration. Am J Pathol (2010) 0.92

Hypoxia and an angiogenic response in the partially obstructed rat bladder. Lab Invest (2002) 0.91

Case for pharmacotherapy development for underactive bladder. Urology (2008) 0.89

Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol (2012) 0.88

Alterations in the contractile phenotype of the bladder: lessons for understanding physiological and pathological remodelling of smooth muscle. J Cell Mol Med (2012) 0.87

Voiding dysfunction due to detrusor underactivity: an overview. Nat Rev Urol (2014) 0.87

The emerging role of class-3 semaphorins and their neuropilin receptors in oncology. Onco Targets Ther (2014) 0.86

Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. J Urol (2009) 0.86

Inducible nitric oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstruction. J Urol (2003) 0.85

Effects of chronic partial outlet obstruction on blood flow and oxygenation of the rat bladder. J Urol (2002) 0.85

Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy. Am J Physiol Cell Physiol (2014) 0.83

Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction. Am J Physiol Regul Integr Comp Physiol (2007) 0.83

Effects of prostaglandins E1, E2 and F2 alpha on contractility and cAMP and cGMP contents in lower urinary tract smooth muscle. Urol Int (1994) 0.82

Altered response to partial bladder outlet obstruction in mice lacking inducible nitric oxide synthase. J Urol (2000) 0.81

Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. Anal Biochem (2014) 0.80

Inhibition of HIF Reduces Bladder Hypertrophy and Improves Bladder Function in Murine Model of Partial Bladder Outlet Obstruction. J Urol (2016) 0.80

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo. Sci Rep (2015) 0.79

Physiologic sequelae of partial infravesical obstruction in the mouse: role of inducible nitric oxide synthase. J Urol (1999) 0.78

Characterization of miRNA-regulated networks, hubs of signaling, and biomarkers in obstruction-induced bladder dysfunction. JCI Insight (2017) 0.77