Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

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Published in PLoS One on February 16, 2017

Authors

Henning Leske1, Simone Hornemann1, Uli Simon Herrmann1, Caihong Zhu1, Paolo Dametto1, Bei Li1, Florent Laferriere2, Magdalini Polymenidou2, Pawel Pelczar3, Regina Rose Reimann1, Petra Schwarz1, Elisabeth Jane Rushing1, Kurt Wüthrich4, Adriano Aguzzi1

Author Affiliations

1: Institute of Neuropathology, University Hospital of Zurich, University of Zurich, Schmelzbergstrasse 12, Zurich, Switzerland.
2: Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland.
3: Institute of Molecular Biology and Biophysics, ETH Zurich, Otto-Stern-Weg 5, Zurich, Switzerland.
4: Department of Integrative Structural and Computational Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America.

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