Published in J Dermatol Sci on February 20, 2017
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet (2006) 9.99
Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry (2006) 2.92
The cytokeratin filament-aggregating protein filaggrin is the target of the so-called "antikeratin antibodies," autoantibodies specific for rheumatoid arthritis. J Clin Invest (1993) 2.37
Characterization of a class of cationic proteins that specifically interact with intermediate filaments. Proc Natl Acad Sci U S A (1981) 2.15
Moisturization and skin barrier function. Dermatol Ther (2004) 2.09
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol (2003) 2.08
Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol (2009) 2.03
Histidine-rich proteins (filaggrins): structural and functional heterogeneity during epidermal differentiation. J Mol Biol (1983) 1.94
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol (2011) 1.93
Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection. J Invest Dermatol (2010) 1.78
Climatic factors are associated with childhood eczema prevalence in the United States. J Invest Dermatol (2013) 1.74
Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol (1986) 1.71
Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data. J Allergy Clin Immunol (2007) 1.71
Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol (2008) 1.67
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry (2010) 1.66
Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med (2004) 1.60
Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy (2011) 1.59
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction. Mol Biol Cell (2007) 1.40
Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol (2009) 1.38
Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin. J Allergy Clin Immunol (2013) 1.30
Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy (2010) 1.19
Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids. J Biol Chem (2009) 1.19
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin. J Invest Dermatol (2005) 1.15
Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus. J Allergy Clin Immunol (2010) 1.12
Detection of deiminated proteins in rat skin: probing with a monospecific antibody after modification of citrulline residues. J Invest Dermatol (1995) 1.12
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest (2010) 1.08
The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. Cell Mol Life Sci (2005) 1.08
A novel in situ method for the detection of deficient transglutaminase activity in the skin. Arch Dermatol Res (1998) 1.05
Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy (2012) 1.05
Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol (1998) 1.04
Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch Biochem Biophys (2002) 1.02
SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing. EMBO Mol Med (2011) 1.02
Independent regulation of two cytoplasmic processing stages of the intermediate filament-associated protein filaggrin and role of Ca2+ in the second stage. J Biol Chem (1993) 0.97
Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis. Biochem J (1996) 0.97
Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis. J Allergy Clin Immunol (2014) 0.96
Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases. Int J Cosmet Sci (2007) 0.95
Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases. Cell Mol Life Sci (2010) 0.93
Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes. J Dermatol Sci (2008) 0.92
Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. J Biol Chem (2011) 0.89
Skin barrier in atopic dermatitis. Front Biosci (Landmark Ed) (2014) 0.89
Urocanic acid in the skin: a mixed blessing? J Invest Dermatol (2011) 0.87
Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants. J Pediatr (2006) 0.87
Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes. J Biol Chem (2013) 0.85
Epidermal morphogenesis during progressive in vitro 3D reconstruction at the air-liquid interface. Exp Dermatol (2012) 0.85
Effect of climatic change in children with atopic eczema. Allergy (2006) 0.83
Lowered humidity produces human epidermal equivalents with enhanced barrier properties. Tissue Eng Part C Methods (2015) 0.82
The effect of environmental humidity and temperature on skin barrier function and dermatitis. J Eur Acad Dermatol Venereol (2015) 0.82
Knockdown of filaggrin in a three-dimensional reconstructed human epidermis impairs keratinocyte differentiation. J Invest Dermatol (2014) 0.82
Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. PLoS One (2012) 0.81
Impact of filaggrin mutations on Raman spectra and biophysical properties of the stratum corneum in mild to moderate atopic dermatitis. J Eur Acad Dermatol Venereol (2011) 0.80
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins. Exp Dermatol (2015) 0.80
Cuts by caspase-14 control the proteolysis of filaggrin. J Invest Dermatol (2011) 0.78
Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects. J Cell Sci (2014) 0.78
Dynamic aspects of protein deimination in developing mouse epidermis. Exp Dermatol (1999) 0.77
Rab11a Is Essential for Lamellar Body Biogenesis in the Human Epidermis. J Invest Dermatol (2016) 0.77
Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate. J Dermatol Sci (2014) 0.76
Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis. Biol Chem (2015) 0.76
Molecular Genetic of Atopic dermatitis: An Update. Int J Health Sci (Qassim) (2016) 0.75
Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget (2015) 0.83
Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation. Eur J Immunol (2016) 0.76
Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Sci Rep (2016) 0.75