Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.

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🔗 View Article (PMID 28297679)

Published in Cell Rep on March 14, 2017

Authors

Farshad Farshidfar¹, Siyuan Zheng², Marie-Claude Gingras³, Yulia Newton⁴, Juliann Shih⁵, A Gordon Robertson⁶, Toshinori Hinoue⁷, Katherine A Hoadley⁸, Ewan A Gibb⁶, Jason Roszik², Kyle R Covington³, Chia-Chin Wu², Eve Shinbrot³, Nicolas Stransky⁹, Apurva Hegde², Ju Dong Yang¹⁰, Ed Reznik¹¹, Sara Sadeghi⁶, Chandra Sekhar Pedamallu⁵, Akinyemi I Ojesina¹², Julian M Hess¹³, J Todd Auman¹⁴, Suhn K Rhie¹⁵, Reanne Bowlby⁶, Mitesh J Borad¹⁶, Cancer Genome Atlas Network, Andrew X Zhu¹⁷, Josh M Stuart⁴, Chris Sander¹¹, Rehan Akbani², Andrew D Cherniack⁵, Vikram Deshpande¹⁸, Taofic Mounajjed¹⁰, Wai Chin Foo², Michael S Torbenson¹⁰, David E Kleiner¹⁹, Peter W Laird⁷, David A Wheeler³, Autumn J McRee²⁰, Oliver F Bathe¹, Jesper B Andersen²¹, Nabeel Bardeesy²², Lewis R Roberts²³, Lawrence N Kwong²⁴

Author Affiliations

1: Departments of Surgery and Oncology, Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB T2N 4N1, Canada.
2: Departments of Genomic Medicine, Melanoma Medical Oncology, Bioinformatics and Computational Biology, Pathology, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
3: Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
4: University of California Santa Cruz, Santa Cruz, CA 95064, USA.
5: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
6: Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
7: Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
8: Departments of Genetics and Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
9: Blueprint Medicines, 38 Sidney Street, Cambridge, MA 02139, USA.
10: Divisions of Gastroenterology and Hepatology and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
11: Memorial Sloan Kettering Cancer Center, New York, NY 10005, USA.
12: University of Alabama at Birmingham, Birmingham, AL 35294, USA; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA.
13: The Eli and Edythe L. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
14: Departments of Genetics and Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
15: USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA.
16: Division of Hematology and Oncology, Mayo Clinic, Scottsdale, AZ 85054, USA.
17: Departments of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
18: Departments of Pathology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
19: National Cancer Institute, Bethesda, MD 20892, USA.
20: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
21: Biotech Research and Innovation Centre, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address: jesper.andersen@bric.ku.dk.
22: Departments of Pathology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: bardeesy.nabeel@mgh.harvard.edu.
23: Divisions of Gastroenterology and Hepatology and Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address: roberts.lewis@mayo.edu.
24: Departments of Genomic Medicine, Melanoma Medical Oncology, Bioinformatics and Computational Biology, Pathology, and Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: lkwong@mdanderson.org.