Published in Elife on March 17, 2017
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science (1991) 12.00
Role of histone H2A ubiquitination in Polycomb silencing. Nature (2004) 9.48
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (2002) 7.33
Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell (1999) 6.90
Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells. Cell (2011) 6.22
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. EMBO J (2006) 3.21
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol (2006) 2.99
Rapid generation of inducible mouse mutants. Nucleic Acids Res (2003) 2.77
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Development (2008) 2.53
A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Development (1996) 2.33
The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. Mol Cell (2006) 2.26
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell (2014) 2.20
RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells. Cell Rep (2012) 2.03
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell (2013) 1.97
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell (2013) 1.86
Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells. J Cell Biol (2007) 1.82
Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol (2013) 1.61
Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. Mol Cell (2014) 1.57
A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. Mol Cell (2007) 1.52
Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes. Mol Cell Biol (2005) 1.46
Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. EMBO J (1999) 1.45
Production of monoclonal antibodies against mammalian Ring1B proteins. Hybridoma (2001) 1.44
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment. Cell Rep (2014) 1.43
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet (2012) 1.40
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development (2002) 1.26
Indefinite self-renewal of ESCs through Myc/Max transcriptional complex-independent mechanisms. Cell Stem Cell (2011) 1.20
Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics (2011) 1.18
Targeting Polycomb systems to regulate gene expression: modifications to a complex story. Nat Rev Mol Cell Biol (2015) 1.15
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell (2012) 1.08
Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Mol Cell Biol (2010) 1.00
MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation. Genes Cells (2002) 0.93
Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells. Nat Commun (2013) 0.91
Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells. Nat Commun (2016) 0.88
The dynamic interactome and genomic targets of Polycomb complexes during stem-cell differentiation. Nat Struct Mol Biol (2016) 0.83
Embracing change to remain the same: conservation of polycomb functions despite divergence of binding motifs among species. Curr Opin Cell Biol (2013) 0.83
Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA. Cell Stem Cell (2016) 0.81
A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep (2016) 0.79
Pcgf6, a polycomb group protein, regulates mesodermal lineage differentiation in murine ESCs and functions in iPS reprogramming. Stem Cells (2014) 0.79
Stepwise differentiation from naïve state pluripotent stem cells to functional primordial germ cells through an epiblast-like state. Methods Mol Biol (2013) 0.79
Polycomb Group Protein Pcgf6 Acts as a Master Regulator to Maintain Embryonic Stem Cell Identity. Sci Rep (2016) 0.78
Mga is essential for the survival of pluripotent cells during peri-implantation development. Development (2015) 0.78
Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis. Elife (2016) 0.77
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. Elife (2016) 0.75
The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells. Elife (2017) 0.75
Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. PLoS One (2016) 0.75
Link between embryonic stem cell pluripotency and homologous allelic pairing of Oct4 loci. Dev Growth Differ (2017) 0.75
Possibilities in Germ Cell Research: An Engineering Insight. Trends Biotechnol (2015) 0.75
Does MAX open up a new avenue for meiotic research? Dev Growth Differ (2017) 0.75
Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice. Dis Model Mech (2019) 0.75
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies. J Exp Med (2017) 0.75